Signaling in Myocardial Hypertrophy

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function

1997 • 2,571 citations

A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

1998 • 2,570 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

The extended protein kinase C superfamily

1998 • 1,544 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Double identity for proteins of the Bcl-2 family

1997 • 1,511 citations

Apoptosis in Myocytes in End-Stage Heart Failure

1996 • 1,446 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type

1998 • 998 citations

Structure And Evolution Of Calcium-Modulated Protein

1980 • 942 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Apoptosis

1998 • 806 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

The Heart in Hypertension

1992 • 774 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart.

1993 • 708 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Theory of excitation-contraction coupling in cardiac muscle

1992 • 651 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum

1998 • 639 citations

Transgenic Gαq overexpression induces cardiac contractile failure in mice

1997 • 636 citations

Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.

1992 • 611 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Na+/H+ Exchangers of Mammalian Cells

1997 • 586 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

Calcium-Binding Proteins

2011 • 582 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Survey of Studies Examining Mammalian Cardiomyocyte DNA Synthesis

1998 • 555 citations

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

1995 • 548 citations

The search for physiological substrates of MAP and SAP kinases in mammalian cells

1997 • 544 citations

Rho GTPases

1998 • 534 citations

Csx: a murine homeobox-containing gene specifically expressed in the developing heart.

1993 • 533 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

“Stress-Responsive” Mitogen-Activated Protein Kinases (c-Jun N-Terminal Kinases and p38 Mitogen-Activated Protein Kinases) in the Myocardium

1998 • 510 citations

Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA

1998 • 510 citations

Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.

1991 • 505 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

1998 • 494 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

1996 • 487 citations

Stimulation of hypertrophy of cultured neonatal rat heart cells through an alpha 1-adrenergic receptor and induction of beating through an alpha 1- and beta 1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating.

1985 • 485 citations

Regulation and function of the JNK subgroup of MAP kinases

1997 • 484 citations

Calcium-Binding Proteins

1976 • 479 citations

Stretching cardiac myocytes stimulates protooncogene expression.

1990 • 470 citations

Medical Therapy Can Improve the Biological Properties of the Chronically Failing Heart

1996 • 468 citations

Prevention of Cardiac Hypertrophy in Mice by Calcineurin Inhibition

1998 • 467 citations

Targeting the Receptor-G _q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy

1998 • 457 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation.

1991 • 437 citations

Alterations of calcium-regulatory proteins in heart failure

1998 • 432 citations

Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12

1998 • 422 citations

Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

1997 • 422 citations

The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death

1996 • 420 citations

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes

1995 • 412 citations

Cellular mechanisms of cardiac hypertrophy

1998 • 409 citations

Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes.

1993 • 401 citations

Endothelin-1 Is Involved in Mechanical Stress-induced Cardiomyocyte Hypertrophy

1996 • 400 citations

Cardiotrophin 1 (CT-1) Inhibition of Cardiac Myocyte Apoptosis via a Mitogen-activated Protein Kinase-dependent Pathway

1997 • 399 citations

Ventricular Myocytes Are Not Terminally Differentiated in the Adult Mammalian Heart

1998 • 395 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Targeted overexpression of protein kinase C β2 isoform in myocardium causes cardiomyopathy

1997 • 388 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes.

1990 • 377 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Death by Design

1997 • 364 citations

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

1997 • 347 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Control of Cardiac Gene Expression by Mechanical Stress

1993 • 343 citations

Cardiac Hypertrophy Induced by Mitogen-activated Protein Kinase Kinase 7, a Specific Activator for c-Jun NH2-terminal Kinase in Ventricular Muscle Cells

1998 • 335 citations

Untitled

1997 • 328 citations

Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation.

1997 • 326 citations

Regulation of the ERK Subgroup of MAP Kinase Cascades Through G Protein-Coupled Receptors

1997 • 323 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Ventricular Expression of a MLC-2v-ras Fusion Gene Induces Cardiac Hypertrophy and Selective Diastolic Dysfunction in Transgenic Mice

1995 • 314 citations

Stimulation of the p38 Mitogen-activated Protein Kinase Pathway in Neonatal Rat Ventricular Myocytes by the G Protein–coupled Receptor Agonists, Endothelin-1 and Phenylephrine: A Role in Cardiac Myocyte Hypertrophy?

1998 • 313 citations

Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1

1998 • 306 citations

The riddle of MAP kinase signaling specificity

1998 • 297 citations

Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin.

1998 • 282 citations

Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes

1994 • 280 citations

Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts

1994 • 278 citations

The Cardiac Tissue-Restricted Homeobox Protein Csx/Nkx2.5 Physically Associates with the Zinc Finger Protein GATA4 and Cooperatively Activates Atrial Natriuretic Factor Gene Expression

1998 • 274 citations

Protein Kinase A Anchoring

1997 • 272 citations

A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription.

1994 • 271 citations

Transient cardiac expression of constitutively active Gα_qleads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

1998 • 262 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Protein kinase C isoform expression and regulation in the developing rat heart.

1994 • 245 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

Cardiac alpha 1-adrenoceptors: an overview.

1993 • 243 citations

Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy

1998 • 234 citations

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

1997 • 234 citations

The MEKK-JNK Pathway Is Stimulated by α1-Adrenergic Receptor and Ras Activation and Is Associated with in Vitro and in Vivo Cardiac Hypertrophy

1997 • 231 citations

Altered calcium handling in experimental pressure-overload hypertrophy in the ferret.

1985 • 229 citations

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart.

1991 • 228 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner

1998 • 227 citations

Angiotensin II Activates RhoA in Cardiac Myocytes

1998 • 224 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

FKBP12 Binds the Inositol 1,4,5-Trisphosphate Receptor at Leucine-Proline (1400–1401) and Anchors Calcineurin to this FK506-like Domain

1997 • 216 citations

Cellular Stresses Differentially Activate c-Jun N-terminal Protein Kinases and Extracellular Signal-regulated Protein Kinases in Cultured Ventricular Myocytes

1995 • 212 citations

Ca2+ ions can affect intracellular pH in mammalian cardiac muscle

1983 • 210 citations

Depletion of Mitogen-Activated Protein Kinase Using an Antisense Oligodeoxynucleotide Approach Downregulates the Phenylephrine-Induced Hypertrophic Response in Rat Cardiac Myocytes

1996 • 209 citations

T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A

1998 • 209 citations

Calcium signaling in the cell nucleus

1997 • 208 citations

The Nuclear δB Isoform of Ca2+/Calmodulin-dependent Protein Kinase II Regulates Atrial Natriuretic Factor Gene Expression in Ventricular Myocytes

1997 • 208 citations

Decompensation of Pressure-Overload Hypertrophy in Gαq-Overexpressing Mice

1998 • 204 citations

Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy.

1994 • 199 citations

Role of the stress-activated protein kinases in endothelin-induced cardiomyocyte hypertrophy.

1998 • 198 citations

The Low Molecular Weight GTPase Rho Regulates Myofibril Formation and Organization in Neonatal Rat Ventricular Myocytes

1998 • 194 citations

Cardiac-specific Overexpression of Mouse Cardiac Calsequestrin Is Associated with Depressed Cardiovascular Function and Hypertrophy in Transgenic Mice

1998 • 193 citations

Calcineurin mediates alpha-adrenergic stimulation of Na+,K(+)-ATPase activity in renal tubule cells.

1992 • 191 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to α1-adrenergic and phorbol ester stimulation

1988 • 185 citations

Stimulation of multiple mitogen-activated protein kinase sub-families by oxidative stress and phosphorylation of the small heat shock protein, HSP25/27, in neonatal ventricular myocytes

1998 • 182 citations

Endothelin‐1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes

1993 • 179 citations

cis -Acting Sequences That Mediate Induction of β-Myosin Heavy Chain Gene Expression During Left Ventricular Hypertrophy due to Aortic Constriction

1997 • 177 citations

Dissociation of p44 and p42 Mitogen-activated Protein Kinase Activation from Receptor-induced Hypertrophy in Neonatal Rat Ventricular Myocytes

1996 • 176 citations

Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes

1995 • 176 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

Rapamycin Inhibits α ₁ -Adrenergic Receptor–Stimulated Cardiac Myocyte Hypertrophy but Not Activation of Hypertrophy-Associated Genes

1997 • 169 citations

Adrenergic receptor stimulation of the mitogen-activated protein kinase cascade and cardiac hypertrophy

1996 • 165 citations

The role of action potential prolongation and altered intracellular calcium handling in the pathogenesis of heart failure

1998 • 162 citations

Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene

1991 • 161 citations

Identification and Functional Reconstitution of the Type 2 Inositol 1,4,5-Trisphosphate Receptor from Ventricular Cardiac Myocytes

1997 • 160 citations

The Mitogen-activated Protein Kinase Kinase MEK1 Stimulates a Pattern of Gene Expression Typical of the Hypertrophic Phenotype in Rat Ventricular Cardiomyocytes

1995 • 159 citations

Calcineurin: Not Just a Simple Protein Phosphatase

1997 • 159 citations

Cyclosporin A Inhibits Apoptosis of Human Endothelial Cells by Preventing Release of Cytochrome C From Mitochondria

1998 • 158 citations

Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomyocytes in transgenic mice.

1993 • 155 citations

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

1997 • 152 citations

Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells

1990 • 134 citations

Ca2+ currents in compensated hypertrophy and heart failure

1998 • 131 citations

p38 Mitogen-activated Protein Kinase Mediates the Transcriptional Induction of the Atrial Natriuretic Factor Gene through a Serum Response Element

1998 • 128 citations

Prevention of Cardiac Hypertrophy by Calcineurin Inhibition

1999 • 126 citations

Biphasic Activation of the JAK/STAT Pathway by Angiotensin II in Rat Cardiomyocytes

1998 • 114 citations

Rapid targeting of nuclear proteins to the cytoplasm

1997 • 112 citations

Raf-1 kinase activity is necessary and sufficient for gene expression changes but not sufficient for cellular morphology changes associated with cardiac myocyte hypertrophy.

1994 • 109 citations

Prostaglandin F2α Stimulates Hypertrophic Growth of Cultured Neonatal Rat Ventricular Myocytes

1996 • 107 citations

The Cyclosporin A-sensitive Nuclear Factor of Activated T Cells (NFAT) Proteins Are Expressed in Vascular Smooth Muscle Cells

1998 • 102 citations

Brain natriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes

1994 • 97 citations

Autocrine/Paracrine Determinants of Strain-activated Brain Natriuretic Peptide Gene Expression in Cultured Cardiac Myocytes

1998 • 94 citations

Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506

1998 • 94 citations

Ambulatory blood pressure and left ventricular mass in cyclosporin- and non-cyclosporin-treated renal transplant recipients

1993 • 93 citations

Cyclosporine A limits myocardial infarct size even when administered after onset of ischemia

1998 • 86 citations

GTPases in antigen receptor signalling

1998 • 83 citations

Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506

1998 • 82 citations

Networking Rho Family GTPases in Lymphocytes

1998 • 82 citations

Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo

1996 • 81 citations

The Raf-MEK-ERK Cascade Represents a Common Pathway for Alteration of Intracellular Calcium by Ras and Protein Kinase C in Cardiac Myocytes

1998 • 81 citations

Inhibition of a signaling pathway in cardiac muscle cells by active mitogen-activated protein kinase kinase.

1995 • 79 citations

Collaborative Roles for c-Jun N-terminal Kinase, c-Jun, Serum Response Factor, and Sp1 in Calcium-regulated Myocardial Gene Expression

1997 • 78 citations

Effects of angiotensin II on intracellular Ca2+ and pH in isolated beating rabbit hearts and myocytes loaded with the indicator indo‐1.

1994 • 77 citations

Expression of protein kinase C isoforms during cardiac ventricular development

1995 • 75 citations

Classical, novel and atypical isoforms of PKC stimulate ANF‐ and TRE/AP‐1‐regulated‐promoter activity in ventricular cardiomyocytes

1994 • 75 citations

Skeletal muscle abnormalities and evidence for their role in symptom generation in chronic heart failure

1997 • 75 citations

Endothelins. Myocardial actions of a new class of cytokines.

1992 • 74 citations

Modulation of intracellular Ca2+ levels in the heart by sorcin and FKBP12, two accessory proteins of ryanodine receptors

1998 • 72 citations

Pathologic changes in the long-term transplanted heart: A morphometric study of myocardial hypertrophy, vascularity, and fibrosis

1990 • 70 citations

c-Src Activation Plays a Role in Endothelin-dependent Hypertrophy of the Cardiac Myocyte

1998 • 70 citations

Oncogenic src, raf, and rasStimulate a Hypertrophic Pattern of Gene Expression and Increase Cell Size in Neonatal Rat Ventricular Myocytes

1998 • 70 citations

Stimulation of phosphatidylinositol hydrolysis, protein kinase C translocation, and mitogen-activated protein kinase activity by bradykinin in rat ventricular myocytes: dissociation from the hypertrophic response

1996 • 66 citations

Angiotensin II Activates Stat5 Through Jak2 Kinase in Cardiac Myocytes

1998 • 65 citations

Ras and Rho are Required for Gαq-Induced Hypertrophic Gene Expression in Neonatal Rat Cardiac Myocytes

1998 • 63 citations

Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice

1997 • 63 citations

Induction of NFAT-mediated Transcription by Gq-coupled Receptors in Lymphoid and Non-lymphoid Cells

1996 • 63 citations

Mitogen-activated protein kinase phosphatase 1 inhibits the stimulation of gene expression by hypertrophic agonists in cardiac myocytes

1997 • 62 citations

Tyrosine Kinase and c-Jun NH ₂ -Terminal Kinase Mediate Hypertrophic Responses to Prostaglandin F _2α in Cultured Neonatal Rat Ventricular Myocytes

1998 • 61 citations

Variable effects of endothelin-1 on [Ca2+]i transients, pHi, and contraction in ventricular myocytes

1993 • 59 citations

Calcineurin Inhibition and Cardiac Hypertrophy

1998 • 56 citations

Decreased proportion of type I myofibers in skeletal muscle of dogs with chronic heart failure.

1993 • 52 citations

Calcium dependence of phenylephrine-, endothelin-, and potassium chloride-stimulated atrial natriuretic factor secretion from long term primary neonatal rat atrial cardiocytes.

1990 • 51 citations

Dissociation of Left Ventricular Hypertrophy, β-Myosin Heavy Chain Gene Expression, and Myosin Isoform Switch in Rats After Ascending Aortic Stenosis

1997 • 48 citations

Factors Involved in Cardiogenesis and the Regulation of Cardiac-Specific Gene Expression

1996 • 44 citations

Cell Contact as an Independent Factor Modulating Cardiac Myocyte Hypertrophy and Survival in Long-term Primary Culture

1998 • 42 citations

The cellular pathophysiology of progression to heart failure

1996 • 41 citations

Neurohumoral modulation of intracellular pH in the heart

1995 • 40 citations

Cardioprotection by Cyclosporine A in Experimental Ischemia and Reperfusion—Evidence for a Nitric Oxide-dependent Mechanism Mediated by Endothelin

1997 • 37 citations

Endothelin-1-dependent signaling pathways in the myocardium

1996 • 36 citations

Cyclosporin A and FK506 Inhibit Activation-Induced Cell Death in the Murine WEHI-231 B Cell Line

1994 • 35 citations

Correlations between cardiac protein synthesis rates, intracellular pH and the concentrations of creatine metabolites

1991 • 33 citations

Cardiac muscle diseases in genetically engineered mice: evolution of molecular physiology

1995 • 33 citations

Calcineurin—the missing link in cardiac hypertrophy

1998 • 32 citations

Cardiovascular adaptation to cyclosporine-induced hypertension.

1994 • 31 citations

Strategies for Studying Cardiovascular Phenotypes in Genetically Manipulated Mice

1996 • 29 citations

Assessment of early left ventricular remodeling in orthotopic heart transplant recipients with cine magnetic resonance imaging: potential mechanisms.

1997 • 27 citations

Biggest Extinction Looks Catastrophic

1998 • 15 citations

Regulation of Cytoskeleton and Cell Adhesions by the Small GTPase Rho and Its Targets

1998 • 11 citations

Signaling Path May Lead to Better Heart-Failure Therapies

1998 • 11 citations

Phosphorylation c-Jun and ATF2 in ventricular myocytes by endothelin and phenylephrine

1997 • 5 citations