Dissociation of p44 and p42 Mitogen-activated Protein Kinase Activation from Receptor-induced Hypertrophy in Neonatal Rat Ventricular Myocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism.

1993 • 678 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for myocardial cell hypertrophy

1990 • 641 citations

Norepinephrine-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1 adrenergic response.

1983 • 618 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.

1990 • 444 citations

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes

1995 • 412 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy

1993 • 299 citations

Mechanical loading activates mitogen-activated protein kinase and S6 peptide kinase in cultured rat cardiac myocytes

1993 • 290 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Differential activation of protein kinase C isoforms by endothelin-1 and phenylephrine and subsequent stimulation of p42 and p44 mitogen-activated protein kinases in ventricular myocytes cultured from neonatal rat hearts

1994 • 278 citations

Muscarinic receptor subtypes in airways

1993 • 254 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different from phosphoinositide turnover and adenylylcyclase inhibition.

1992 • 235 citations

HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy.

1993 • 228 citations

Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy.

1994 • 199 citations

Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.

1994 • 189 citations

Alpha 1-adrenergic stimulation of cardiac gene transcription in neonatal rat myocardial cells. Effects on myosin light chain-2 gene expression.

1988 • 185 citations

Endothelin‐1, phorbol esters and phenylephrine stimulate MAP kinase activities in ventricular cardiomyocytes

1993 • 179 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

Structure, organization, and expression of the rat cardiac myosin light chain-2 gene

1989 • 140 citations

Cardiac myocytes as targets for the action of peptide growth factors.

1990 • 126 citations

Involvement of Multiple cis Elements in Basal- and α-Adrenergic Agonist–Inducible Atrial Natriuretic Factor Transcription

1995 • 104 citations

Cell signalling and the control of gene transcription

1994 • 81 citations

Alpha-1 adrenergic stimulation of 1,4,5-inositol trisphosphate formation in ventricular myocytes.

1989 • 73 citations

Extracellular ATP induces immediate-early gene expression but not cellular hypertrophy in neonatal cardiac myocytes.

1994 • 56 citations

Inhibition of slow-wave repolarization and Ca(2+)-activated K+ channels by quaternary ammonium ions

1993 • 42 citations

Phosphoinositide-generated second messengers in cardiac signal transduction

1992 • 32 citations

M1Muscarinic Receptors Heterologously Expressed in Cardiac Myocytes Mediate Ras-dependent Changes in Gene Expression

1995 • 28 citations