Biphasic Activation of the JAK/STAT Pathway by Angiotensin II in Rat Cardiomyocytes

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Pathological hypertrophy and cardiac interstitium. Fibrosis and renin-angiotensin-aldosterone system.

1991 • 2,017 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Cytokine signal transduction

1994 • 1,358 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor

1991 • 1,247 citations

Cytokine receptor signalling

1995 • 1,242 citations

Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor

1991 • 808 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor

1995 • 737 citations

Regulation of blood pressure by the type 1A angiotensin II receptor gene.

1995 • 599 citations

Expression cloning of cardiotrophin 1, a cytokine that induces cardiac myocyte hypertrophy.

1995 • 548 citations

Cardiotrophin-1

1995 • 432 citations

The cardiac renin-angiotensin system. An appraisal of present experimental and clinical evidence.

1991 • 429 citations

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes

1995 • 412 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells

1990 • 358 citations

Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.

1994 • 304 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

Characterization of angiotensin II receptor subtypes in rat heart.

1992 • 236 citations

Roles of JAKs in Activation of STATs and Stimulation of c-fos Gene Expression by Epidermal Growth Factor

1996 • 221 citations

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

1995 • 211 citations

Angiotensin II Stimulation of Left Ventricular Hypertrophy in Adult Rat Heart

1992 • 207 citations

Angiotensin II–Induced Growth Responses in Isolated Adult Rat Hearts

1995 • 200 citations

Activation of JAK-STAT and MAP Kinases by Leukemia Inhibitory Factor Through gp130 in Cardiac Myocytes

1996 • 192 citations

Regulation, Chamber Localization, and Subtype Distribution of Angiotensin II Receptors in Human Hearts

1995 • 191 citations

Angiotensin II stimulates sis-inducing factor-like DNA binding activity. Evidence that the AT1A receptor activates transcription factor-Stat91 and/or a related protein.

1994 • 182 citations

Inducible binding of a factor to the c-fos regulatory region.

1987 • 168 citations

Leukemia Inhibitory Factor, a Potent Cardiac Hypertrophic Cytokine, Activates the JAK/STAT Pathway in Rat Cardiomyocytes

1997 • 160 citations

Phosphorylation and Activation of the DNA Binding Activity of Purified Stat1 by the Janus Protein-tyrosine Kinases and the Epidermal Growth Factor Receptor

1995 • 157 citations

Differential gene expression and regulation of angiotensin II receptor subtypes in rat cardiac fibroblasts and cardiomyocytes in culture.

1994 • 155 citations

Angiotensin II type I receptor antagonist inhibits the gene expression of transforming growth factor-beta 1 and extracellular matrix in cardiac and vascular tissues of hypertensive rats.

1995 • 146 citations

Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II

1994 • 122 citations

Inhibition by angiotensin II type 1 receptor antagonist of cardiac phenotypic modulation after myocardial infarction

1995 • 87 citations

Activation of the STAT Pathway by Angiotensin II in T3CHO/AT1A Cells

1995 • 74 citations

Importance of Tyrosine Phosphorylation in Angiotensin II Type 1 Receptor Signaling

1996 • 65 citations

Role of AT1 receptors in the resetting of the baroreflex control of heart rate by angiotensin II in the rabbit.

1993 • 53 citations

Transforming growth factor 1 and extracellular matrix gene expression in isoprenaline induced cardiac hypertrophy: effects of inhibition of the renin-angiotensin system

1994 • 48 citations

Regulation of the Angiotensin Receptor Subtypes in Cell Cultures, Animal Models and Human Diseases

1994 • 32 citations

The cardiac renin-angiotensin system: a synopsis of current experimental and clinical data.

1991 • 24 citations

Coagulation and platelet activation pathways: A review of the key components and the way in which these can be manipulated

1995 • 20 citations

Intravascular ultrasound: a guide for management of complications during intervention?

1995 • 9 citations