Death by Design

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Apoptosis by Death Factor

1997 • 5,038 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

1996 • 1,976 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest

1994 • 1,475 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3

1993 • 1,387 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

1995 • 1,237 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

1996 • 1,027 citations

Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart

1996 • 993 citations

BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases

1996 • 911 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

1996 • 780 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.

1992 • 689 citations

Apoptosis in Human Atherosclerosis and Restenosis

1995 • 684 citations

Stretch-induced programmed myocyte cell death.

1995 • 647 citations

Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Evidence for apoptosis in advanced human atheroma. Colocalization with interleukin-1 beta-converting enzyme.

1995 • 643 citations

A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.

1996 • 637 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Molecular Ordering of the Cell Death Pathway

1996 • 589 citations

Programmed Cell Death in the Immune System

1991 • 575 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors.

1996 • 515 citations

Acute Myocardial Infarction in Humans is Associated with Activation of Programmed Myocyte Cell Death in the Surviving Portion of the Heart

1996 • 515 citations

The CED-3/ICE-like Protease Mch2 Is Activated during Apoptosis and Cleaves the Death Substrate Lamin A

1996 • 466 citations

Apoptosis of Vascular Smooth Muscle Cells Induced by In Vitro Stimulation With Interferon-γ, Tumor Necrosis Factor–α, and Interleukin-1β

1996 • 435 citations

Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability.

1996 • 420 citations

Apoptosis in pressure overload-induced heart hypertrophy in the rat.

1996 • 416 citations

Cell cycle and apoptosis: Common pathways to life and death

1995 • 404 citations

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

1995 • 397 citations

Cytokine mRNA expression in postischemic/reperfused myocardium.

1995 • 375 citations

Bcl–2 protects from lethal hepatic apoptosis induced by an ant–Fas antibody in mice

1996 • 370 citations

Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.

1996 • 335 citations

Apoptosis and the cell cycle

1995 • 334 citations

Normal and abnormal consequences of apoptosis in the human heart. From postnatal morphogenesis to paroxysmal arrhythmias.

1994 • 318 citations

DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis.

1995 • 271 citations

The cellular basis of dilated cardiomyopathy in humans

1995 • 261 citations

Apoptosis in Target Organs of Hypertension

1995 • 257 citations

Preconditioning rabbit cardiomyocytes: role of pH, vacuolar proton ATPase, and apoptosis.

1996 • 233 citations

Myocyte nuclear mitotic division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs.

1995 • 209 citations

The Cellular Basis of Pacing-Induced Dilated Cardiomyopathy

1995 • 198 citations

A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

1995 • 194 citations

Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.

1993 • 187 citations

Cardiotrophin-1 displays early expression in the murine heart tube and promotes cardiac myocyte survivals

1996 • 183 citations

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.

1996 • 182 citations

Spermine prevents endonuclease activation and apoptosis in thymocytes*1

1991 • 181 citations

Regression or Progression

1996 • 181 citations

Serum interleukin 6 levels become elevated in acute myocardial infarction

1992 • 179 citations

Programmed Cell Death and Expression of the Protooncogene bcl-2 in Myocytes during Postnatal Maturation of the Heart

1995 • 177 citations

Bc1-2 protects mice against fatal alphavirus encephalitis.

1996 • 172 citations

Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus.

1994 • 160 citations

Adenovirus E1A Represses Cardiac Gene Transcription and Reactivates DNA Synthesis in Ventricular Myocytes, via Alternative Pocket Protein- and p300-binding Domains

1995 • 153 citations

Bcl-2 and the ICE family of apoptotic regulators: making a connection

1997 • 147 citations

Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.

1996 • 144 citations

Cytological and cytochemical studies on cell death and digestion in the foetal rat foot: The role of macrophages and hydrolytic enzymes

1968 • 129 citations

Human E2F-1 Reactivates Cell Cycle Progression in Ventricular Myocytes and Represses Cardiac Gene Transcription

1996 • 120 citations

In situ apoptosis assay for the detection of early acute myocardial infarction.

1996 • 109 citations

Myocyte nuclear and possible cellular hyperplasia contribute to ventricular remodeling in the hypertrophic senescent heart in humans

1994 • 101 citations

Death by any other name.

1995 • 90 citations

Apoptosis: Programmed cell death in fetal development

1996 • 85 citations

Tumor suppressor gene expression during normal and pathologic myocardial growth.

1994 • 76 citations

Foam cell replication and smooth muscle cell apoptosis in human saphenous vein grafts

1994 • 74 citations

Apoptosis and DNA Fragmentation in the Bulbus Cordis of the Developing Rat Heart

1996 • 57 citations

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo.

1995 • 57 citations

Myocardial infarction is coupled with activation of cyclins and cyclin-dependent kinases in myocytes.

1996 • 45 citations

Cell death in the failing heart: Role of an unnatural growth response to overload-Cell death in the failing heart

1995 • 37 citations

Myocardial Infarction Is Coupled with the Activation of Cyclins and Cyclin-Dependent Kinases in Myocytes

1996 • 33 citations

Ultrastructure of cell death in bulbar cushions of chick embryo heart

1973 • 25 citations

5 Mechanisms of Programmed Cell Death in Caenorhabditis elegans and Vertebrates

1996 • 19 citations

Measurement by quantitative reverse transcription-polymerase chain reaction of the levels of tumor necrosis factor alpha mRNA in atherosclerotic arteries in Watanabe heritable hyperlipidemic rabbits.

1996 • 9 citations