Regulation and function of the JNK subgroup of MAP kinases

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

1991 • 3,396 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Mammalian Ras interacts directly with the serine/threonine kinase raf

1993 • 1,983 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

1995 • 1,562 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

1995 • 1,453 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Selective interaction of JNK protein kinase isoforms with transcription factors.

1996 • 1,333 citations

The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

1993 • 1,313 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

1988 • 1,256 citations

Coupling of the RAS-MAPK Pathway to Gene Activation by RSK2, a Growth Factor-Regulated CREB Kinase

1996 • 1,253 citations

An Osmosensing Signal Transduction Pathway in Yeast

1993 • 1,252 citations

Prostaglandin synthase 2

1996 • 1,212 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

1994 • 1,092 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter

1992 • 980 citations

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

1994 • 978 citations

Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

1993 • 939 citations

Integration of MAP Kinase Signal Transduction Pathways at the Serum Response Element

1995 • 935 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase

1991 • 869 citations

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

1991 • 800 citations

Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2

1993 • 788 citations

Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2

1995 • 775 citations

A gene activated by growth factors is related to the oncogene v-jun.

1988 • 771 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB

1994 • 732 citations

Prolonged activation of jun and collagenase genes by tumour necrosis factor-α

1989 • 726 citations

Protein kinase cascades activated by stress and inflammatory cytokines

1996 • 722 citations

Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1

1994 • 706 citations

Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun

1989 • 698 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Induction of proto-oncogene JUN/AP-1 by serum and TPA

1988 • 689 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

1991 • 685 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.

1995 • 667 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor.

1996 • 650 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Use of an oriented peptide library to determine the optimal substrates of protein kinases

1994 • 645 citations

Components of a New Human Protein Kinase Signal Transduction Pathway

1995 • 644 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

1994 • 639 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

Cross-coupling of the NF-kappa B p65 and Fos/Jun transcription factors produces potentiated biological function.

1993 • 639 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents.

1995 • 603 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

An Osmosensing Signal Transduction Pathway in Mammalian Cells

1994 • 584 citations

Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast

1995 • 578 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation.

1996 • 568 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

c-Jun is essential for normal mouse development and hepatogenesis

1993 • 543 citations

A role for Rho in Ras transformation.

1995 • 538 citations

Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation.

1995 • 535 citations

Extracellular signal-regulated kinases: ERKs in progress.

1991 • 519 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

The c-ets proto-oncogenes encode transcription factors that cooperate with c-Fos and c-Jun for transcriptional activation

1990 • 507 citations

ATF-2 contains a phosphorylation-dependent transcriptional activation domain.

1995 • 504 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents

1995 • 486 citations

jun-D: a third member of the jun gene family.

1989 • 469 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Reduced Ubiquitin-Dependent Degradation of c-Jun After Phosphorylation by MAP Kinases

1997 • 462 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

The serum response element

1992 • 458 citations

Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway

1994 • 458 citations

SH2/SH3 signaling proteins

1994 • 457 citations

A new group of conserved coactivators that increase the specificity of AP-1 transcription factors

1996 • 457 citations

Signal transduction by tumor necrosis factor mediated by JNK protein kinases.

1994 • 456 citations

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

1997 • 454 citations

Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF

1991 • 447 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Transducers of life and death: TNF receptor superfamily and associated proteins.

1996 • 423 citations

Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro.

1993 • 420 citations

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

1990 • 420 citations

A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

1994 • 417 citations

A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.

1996 • 407 citations

Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms

1996 • 396 citations

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

1993 • 393 citations

The gene lin-3 encodes an inductive signal for vulval development in C. elegans

1992 • 392 citations

Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity

1992 • 387 citations

Functional analysis of a growth factor-responsive transcription factor complex

1993 • 386 citations

Increasing cAMP attenuates activation of mitogen-activated protein kinase.

1993 • 383 citations

Heterodimer formation of cJun and ATF-2 is responsible for induction of c-jun by the 243 amino acid adenovirus E1A protein.

1993 • 380 citations

A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

1993 • 373 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

1993 • 362 citations

Three distinct signalling responses by murine fibroblasts to genotoxic stress

1996 • 359 citations

Signal Transduction Pathways Regulated by Mitogen-activated/Extracellular Response Kinase Kinase Kinase Induce Cell Death

1996 • 346 citations

Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73.

1992 • 343 citations

Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene

1994 • 342 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light.

1996 • 338 citations

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

1996 • 331 citations

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

1997 • 330 citations

Molecular Mechanisms of Developmental Neuronal Death

1993 • 330 citations

Ras-Mediated Phosphorylation of a Conserved Threonine Residue Enhances the Transactivation Activities of c-Ets1 and c-Ets2

1996 • 325 citations

The activation of phosphatidylinositol 3-kinase by Ras

1994 • 322 citations

Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.

1995 • 318 citations

Signalling by the sevenless protein tyrosine kinase is mimicked by Rasl activation

1992 • 315 citations

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6.

1996 • 314 citations

The regulation of AP-1 activity by mitogen-activated protein kinases

1996 • 312 citations

Mechanism of inhibition of Raf-1 by protein kinase A.

1994 • 311 citations

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye.

1996 • 310 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

v-src Induces Prostaglandin Synthase 2 Gene Expression by Activation of the c-Jun N-terminal Kinase and the c-Jun Transcription Factor

1995 • 295 citations

Serine 133-Phosphorylated CREB Induces Transcription via a Cooperative Mechanism That May Confer Specificity to Neurotrophin Signals

1995 • 292 citations

The mitogen-activated protein kinase activator

1992 • 285 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress

1995 • 284 citations

Different requirements for formation of Jun: Jun and Jun: Fos complexes.

1989 • 272 citations

Receptor tyrosine kinases

1992 • 271 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

1997 • 257 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1996 • 253 citations

Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva

1991 • 246 citations

Signaling from G Protein-coupled Receptors to c-Jun Kinase Involves βγ Subunits of Heterotrimeric G Proteins Acting on a Ras and Rac1-dependent Pathway

1996 • 246 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

The proliferation of MAP kinase signaling pathways in yeast

1995 • 243 citations

Protein Synthesis Inhibitors Reveal Differential Regulation of Mitogen-Activated Protein Kinase and Stress-Activated Protein Kinase Pathways That Converge on Elk-1

1995 • 243 citations

Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family

1995 • 240 citations

Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

1994 • 239 citations

Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.

1996 • 230 citations

Molecular Cloning of Mitogen-activated Protein/ERK Kinase Kinases (MEKK) 2 and 3

1996 • 227 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

UV Irradiation and Heat Shock Mediate JNK Activation via Alternate Pathways

1995 • 223 citations

The Mixed Lineage Kinase SPRK Phosphorylates and Activates the Stress-activated Protein Kinase Activator, SEK-1

1996 • 221 citations

Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter.

1989 • 220 citations

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1994 • 219 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

p38/RK is essential for stress-induced nuclear responses: JNK/SAPKs and c-Jun/ATF-2 phosphorylation are insufficient

1996 • 217 citations

Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase

1995 • 214 citations

A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans.

1994 • 212 citations

Transforming G Protein-coupled Receptors Potently Activate JNK (SAPK)

1995 • 211 citations

Genetic dissection of a neurodevelopmental pathway: Son of sevenless functions downstream of the sevenless and EGF receptor tyrosine kinases

1991 • 209 citations

A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways.

1994 • 195 citations

Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24

1995 • 192 citations

Activation of Jun Kinase/Stress-activated Protein Kinase by GTPase-deficient Mutants of Gα12 and Gα13

1995 • 178 citations

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

1993 • 177 citations

Regulatory Role of MEF2D in Serum Induction of the c-jun Promoter

1995 • 176 citations

Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p

1995 • 173 citations

Selective Activation of c-Jun Kinase Mitogen-activated Protein Kinase by CD40 on Human B Cells

1995 • 172 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

Suppression of activated Let-60 ras protein defines a role of Caenorhabditis elegans Sur-1 MAP kinase in vulval differentiation.

1994 • 158 citations

Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

1995 • 155 citations

Activation of Protein Kinase Cascades by Osmotic Shock

1995 • 154 citations

c-fos transcriptional activation and repression correlate temporally with the phosphorylation status of TCF.

1993 • 153 citations

Gα12 Stimulates c-Jun NH2-terminal Kinase through the Small G Proteins Ras and Rac

1996 • 152 citations

The DNA Binding Activity of C/EBP Transcription Factors Is Regulated in the G1 Phase of the Hepatocyte Cell Cycle

1995 • 151 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

Activation of Fes Tyrosine Kinase by gp130, an Interleukin-6 Family Cytokine Signal Transducer, and Their Association

1995 • 147 citations

JNK, but not MAPK, activation is associated with Fas‐mediated apoptosis in human T cells

1996 • 142 citations

The mitogen-activated protein kinases, ERK1 and ERK2.

1994 • 137 citations

Dbl and Vav mediate transformation via mitogen-activated protein kinase pathways that are distinct from those activated by oncogenic Ras.

1994 • 134 citations

Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain.

1996 • 134 citations

Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets

1995 • 132 citations

Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo

1997 • 132 citations

Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK.

1996 • 130 citations

c-Abl Activation Regulates Induction of the SEK1/Stress-activated Protein Kinase Pathway in the Cellular Response to 1-β-D-Arabinofuranosylcytosine

1995 • 125 citations

Oncogenic activity of Tiam1 and Rac1 in NIH3T3 cells.

1995 • 124 citations

GTPase-Deficient Gα₁₆ and Gα_q Induce PC12 Cell Differentiation and Persistent Activation of cJun NH₂-Terminal Kinases

1996 • 123 citations

Differential expression of a novel protein kinase in human B lymphocytes. Preferential localization in the germinal center

1994 • 114 citations

Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases.

1987 • 106 citations

junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2.

1994 • 105 citations

Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A.

1994 • 93 citations

MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain.

1994 • 92 citations

ERK3 Is a Constitutively Nuclear Protein Kinase

1996 • 92 citations

Interleukin-1 activates p54 mitogen-activated protein (MAP) kinase/stress-activated protein kinase by a pathway that is independent of p21ras, Raf-1, and MAP kinase kinase.

1994 • 91 citations

Interleukin 1 (IL1) and tumour necrosis factor (TNF) signal transduction

1996 • 90 citations

SAP1a is a nuclear target of signaling cascades involving ERKs.

1995 • 86 citations

A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase

1997 • 75 citations

Ras pathways in Caenorhabditis elegans

1995 • 64 citations

Differential calcium dependence in the activation of c-Jun kinase and mitogen-activated protein kinase by muscarinic acetylcholine receptors in rat 1a cells

1995 • 64 citations

Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity.

1994 • 62 citations

Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Farl

1993 • 59 citations

Protein or RNA synthesis inhibition induces apoptosis of mature human CD4+ T cell blasts

1993 • 58 citations

Monocyte Colony-stimulating Factor Stimulates Binding of Phosphatidylinositol 3-Kinase to Grb2·Sos Complexes in Human Monocytes

1995 • 56 citations