Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

Green Fluorescent Protein as a Marker for Gene Expression

1994 • 6,572 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

1995 • 850 citations

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

1995 • 821 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES

1994 • 634 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase

1993 • 456 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

Calcineurin Binds the Transcription Factor NFAT1 and Reversibly Regulates Its Activity

1996 • 300 citations

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast

1993 • 290 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

NFATx, a Novel Member of the Nuclear Factor of Activated T Cells Family That Is Expressed Predominantly in the Thymus

1995 • 211 citations

Functional domain structure of calcineurin A: mapping by limited proteolysis

1989 • 201 citations

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes.

1993 • 174 citations

Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.

1989 • 163 citations

Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody

1995 • 134 citations

The latch region of calcineurin B is involved in both immunosuppressant-immunophilin complex docking and phosphatase activation

1994 • 105 citations

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp)

1996 • 104 citations