p38 Mitogen-activated Protein Kinase Mediates the Transcriptional Induction of the Atrial Natriuretic Factor Gene through a Serum Response Element

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Transcriptional Regulation by Extracellular signals: Mechanisms and Specificity

1995 • 1,287 citations

MKK3- and MKK6-Regulated Gene Expression Is Mediated by the p38 Mitogen-Activated Protein Kinase Signal Transduction Pathway

1996 • 1,286 citations

Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element

1988 • 983 citations

Cardiac Muscle Cell Hypertrophy and Apoptosis Induced by Distinct Members of the p38 Mitogen-activated Protein Kinase Family

1998 • 855 citations

Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation

1997 • 770 citations

Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element

1992 • 688 citations

Ternary complex factors: growth factor regulated transcriptional activators

1994 • 686 citations

FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2.

1996 • 633 citations

A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes.

1989 • 605 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

A vector for expressing GAL4(1–147) fusions tn mammalian cells

1989 • 558 citations

Mef2 gene expression marks the cardiac and skeletal muscle lineages during mouse embryogenesis

1994 • 553 citations

Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6)

1996 • 519 citations

The ability of a ternary complex to form over the serum response element correlates with serum inducibility of the human c-fos promoter

1989 • 495 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Molecular Pathways Controlling Heart Development

1996 • 485 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

The serum response element

1992 • 458 citations

Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

1991 • 446 citations

Identification of Mitogen-activated Protein (MAP) Kinase-activated Protein Kinase-3, a Novel Substrate of CSBP p38 MAP Kinase

1996 • 346 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

1993 • 267 citations

A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity.

1993 • 253 citations

Cloning of a Novel Mitogen-activated Protein Kinase Kinase Kinase, MEKK4, That Selectively Regulates the c-Jun Amino Terminal Kinase Pathway

1997 • 242 citations

Calcium Activates Serum Response Factor-Dependent Transcription By A Ras- and Elk-1-Independent Mechanism That Involves a Ca²⁺/Calmodulin-Dependent Kinase

1995 • 215 citations

Signalling pathways: Jack of all cascades

1996 • 186 citations

Casein kinase II enhances the DNA binding activity of serum response factor.

1990 • 181 citations

M-CAT, CArG, and Sp1 Elements Are Required for α1-Adrenergic Induction of the Skeletal α-Actin Promoter during Cardiac Myocyte Hypertrophy

1995 • 181 citations

3pK, a Novel Mitogen-Activated Protein (MAP) Kinase-Activated Protein Kinase, Is Targeted by Three MAP Kinase Pathways

1996 • 180 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

Transforming growth factor-beta response elements of the skeletal alpha-actin gene. Combinatorial action of serum response factor, YY1, and the SV40 enhancer-binding protein, TEF-1

1994 • 167 citations

Interaction of ATF6 and serum response factor

1997 • 163 citations

Involvement of Multiple cis Elements in Basal- and α-Adrenergic Agonist–Inducible Atrial Natriuretic Factor Transcription

1995 • 104 citations

3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region

1996 • 92 citations

Differential Effects of Protein Kinase C, Ras, and Raf-1 Kinase on the Induction of the Cardiac B-type Natriuretic Peptide Gene through a Critical Promoter-proximal M-CAT Element

1997 • 63 citations

The avian cardiac alpha-actin promoter is regulated through a pair of complex elements composed of E boxes and serum response elements that bind both positive- and negative-acting factors.

1994 • 45 citations