Classical, novel and atypical isoforms of PKC stimulate ANF‐ and TRE/AP‐1‐regulated‐promoter activity in ventricular cardiomyocytes

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

1992 • 4,480 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Protein kinase C - a question of specificity

1994 • 958 citations

Regulation of cardiac gene expression during myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response

1991 • 798 citations

Activation of Cell-Specific Expression of Rat Growth Hormone and Prolactin Genes by a Common Transcription Factor

1988 • 525 citations

Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1 induction is primarily an alpha 1-mediated response.

1990 • 444 citations

Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy.

1994 • 387 citations

Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element

1989 • 311 citations

Differential regulation of protein kinase C isoforms in isolated neonatal and adult rat cardiomyocytes

1994 • 280 citations

Characterization of protein kinase C isotype expression in adult rat heart. Protein kinase C-epsilon is a major isotype present, and it is activated by phorbol esters, epinephrine, and endothelin.

1993 • 252 citations

Protein kinase C isoform expression and regulation in the developing rat heart.

1994 • 245 citations

Co-regulation of the atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identification of cis sequences within an embryonic and a constitutive contractile protein gene which mediate inducible expression.

1991 • 244 citations

Unique substrate specificity and regulatory properties of PKC‐ε: a rationale for diversity

1989 • 226 citations

Differential acute and chronic response of protein kinase C in cultured neonatal rat heart myocytes to α1-adrenergic and phorbol ester stimulation

1988 • 185 citations

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

1992 • 170 citations

Expression of a constitutively activated mutant of the beta-isozyme of protein kinase C in cardiac myocytes stimulates the promoter of the beta-myosin heavy chain isogene

1991 • 161 citations

Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation

1990 • 144 citations

Phorbol esters induce immediate-early genes and activate cardiac gene transcription in neonatal rat myocardial cells

1990 • 134 citations

Acceleration of growth of cultured cardiomyocytes and translocation of protein kinase C

1992 • 85 citations

Alpha-adrenergic regulation of phosphoinositide metabolism and protein kinase C in isolated cardiac myocytes

1991 • 82 citations

Phorbol ester stimulation of protein kinase C activity and ribosomal DNA transcription. Role in hypertrophic growth of cultured cardiomyocytes.

1991 • 71 citations

Protein kinase C is localized in focal contacts of normal but not transformed fibroblasts

1990 • 70 citations

The regulatory domain of protein kinase C-ε restricts the catalytic-domain-specificity

1991 • 53 citations

Protein synthesis in rat cardiac myocytes is stimulated at the level of translation by phorbol esters

1989 • 40 citations

Activity of both Raf and Ras is necessary for activation of transcription of the human T cell receptor beta gene by protein kinase C, Ras plays multiple roles.

1993 • 39 citations

A phorbol ester‐responsive PKC‐ζ generated by fusion with the regulatory domain of PKC‐δ

1994 • 17 citations