Angiotensin II Activates RhoA in Cardiac Myocytes

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Molecular characterization of angiotensin II--induced hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts. Critical role of the AT1 receptor subtype.

1993 • 1,420 citations

Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro

1993 • 1,347 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

THE CELLULAR AND MOLECULAR RESPONSE OF CARDIAC MYOCYTES TO MECHANICAL STRESS

1997 • 876 citations

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

1997 • 802 citations

Microinjection of recombinant p21rho induces rapid changes in cell morphology.

1990 • 720 citations

Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.

1992 • 611 citations

Oxidative Stress-Induced Actin Reorganization Mediated by the p38 Mitogen-Activated Protein Kinase/Heat Shock Protein 27 Pathway in Vascular Endothelial Cells

1997 • 569 citations

Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cyclic AMP in cytotoxic lymphocytes.

1996 • 560 citations

Asparagine residue in the rho Gene Product Is the Modification Site for Botulinum ADP-ribosyltransferase

1989 • 550 citations

Cardiac Actions of Angiotensin II: Role of an Intracardiac Renin-Angiotensin System

1992 • 505 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Angiotensin II and Other Hypertrophic Stimuli Mediated by G Protein–Coupled Receptors Activate Tyrosine Kinase, Mitogen-Activated Protein Kinase, and 90-kD S6 Kinase in Cardiac Myocytes

1995 • 412 citations

Signal transduction pathways of angiotensin II--induced c-fos gene expression in cardiac myocytes in vitro. Roles of phospholipid-derived second messengers.

1993 • 389 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Transcriptional Regulation During Cardiac Growth and Development

1993 • 371 citations

Control of Cardiac Gene Expression by Mechanical Stress

1993 • 343 citations

The premyofibril: Evidence for its role in myofibrillogenesis

1994 • 328 citations

A Role for the p38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression

1997 • 320 citations

Angiotensin II Partly Mediates Mechanical Stress–Induced Cardiac Hypertrophy

1995 • 309 citations

Angiotensin II Signal Transduction in Vascular Smooth Muscle

1997 • 306 citations

Integrin-mediated signalling: regulation by protein tyrosine kinases and small GTP-binding proteins

1996 • 305 citations

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

1996 • 285 citations

The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.

1996 • 265 citations

The relationship between stress fiber-like structures and nascent myofibrils in cultured cardiac myocytes.

1984 • 264 citations

Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins.

1994 • 245 citations

Myofibrillogenesis visualized in living embryonic cardiomyocytes

1997 • 234 citations

Growth Factors Proto-Oncogenes and Plasticity of the Cardiac Phenotype

1991 • 228 citations

Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors.

1995 • 226 citations

Rapamycin Selectively Inhibits Angiotensin II–Induced Increase in Protein Synthesis in Cardiac Myocytes In Vitro

1995 • 224 citations

Rho Is Required for Gαq and α1-Adrenergic Receptor Signaling in Cardiomyocytes

1996 • 220 citations

Translocation of rhoA Associated with Ca2+ Sensitization of Smooth Muscle

1997 • 218 citations

ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

1993 • 212 citations

Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility.

1994 • 199 citations

Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows.

1995 • 192 citations

The Small GTP-binding Protein Rho Activates c-Jun N-terminal Kinases/Stress-activated Protein Kinases in Human Kidney 293T Cells

1996 • 171 citations

Purification and characterization of an ADP-ribosyltransferase produced by Clostridium limosum.

1992 • 169 citations

Angiotensin II Activates pp60 ^{c- src} in Vascular Smooth Muscle Cells

1995 • 167 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin

1996 • 152 citations

MAP kinase- and Rho-dependent signals interact to regulate gene expression but not actin morphology in cardiac muscle cells

1997 • 152 citations

Differential Translocation of Rho Family GTPases by Lysophosphatidic Acid, Endothelin-1, and Platelet-derived Growth Factor

1996 • 151 citations

Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125^FAK and paxillin induced by bombesin and endothelin

1994 • 138 citations

The vinculin/sarcomeric-alpha-actinin/alpha-actin nexus in cultured cardiac myocytes

1992 • 126 citations

Alteration of the cytoskeleton of mammalian cells cultured in vitro by Clostridium botulinum C2 toxin and C3 ADP-ribosyltransferase.

1991 • 126 citations

Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein

1996 • 125 citations

Activation and Translocation of Rho (and ADP Ribosylation Factor) by Insulin in Rat Adipocytes

1997 • 90 citations

Proto-Oncogenes and Cardiac Hypertrophy

1989 • 84 citations

Angiotensin II induces tyrosine phosphorylation of insulin receptor substrate 1 and its association with phosphatidylinositol 3-kinase in rat heart

1995 • 80 citations

An N-terminal fragment of titin coupled to green fluorescent protein localizes to the Z-bands in living muscle cells: overexpression leads to myofibril disassembly.

1997 • 59 citations

[22] Preparation of native and recombinant Clostridium botulinum C3 ADP-ribosyltransferase and identification of Rho proteins by ADP-ribosylation

1995 • 57 citations

[21] In Vitro ADP-ribosylation of Rho by bacterial ADP-ribosyltransferases

1995 • 57 citations

Tumor promoter induces reorganization of actin filaments and calspectin (fodrin or nonerythroid spectrin) in 3T3 cells.

1988 • 56 citations

Activated Rho A Stimulates c- fos Gene Expression in Myocardial Cells

1997 • 48 citations

Studies on the function of Rho A protein in cardiac myofibrillogenesis

1997 • 43 citations

Involvement of botulinum C3-sensitive GTP-binding proteins in α1-adrenoceptor subtypes mediating Ca2+-sensitization

1995 • 39 citations