Rho GTPases

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

1996 • 2,843 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)

1996 • 1,964 citations

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

1995 • 1,653 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

1995 • 1,499 citations

Regulation of transcription by MAP kinase cascades

1996 • 1,330 citations

The Rho family GTPases RhoA, Racl , and CDC42Hsregulate transcriptional activation by SRF

1995 • 1,280 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

The Ras-Related Protein Cdc42Hs and Bradykinin Promote Formation of Peripheral Actin Microspikes and Filopodia in Swiss 3T3 Fibroblasts

1995 • 1,033 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Wiskott–Aldrich Syndrome Protein, a Novel Effector for the GTPase CDC42Hs, Is Implicated in Actin Polymerization

1996 • 873 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

1996 • 866 citations

p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin

1997 • 819 citations

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1995 • 733 citations

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1997 • 687 citations

Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

1995 • 665 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

1998 • 656 citations

The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells

1994 • 647 citations

Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activated Protein Kinase Activation

1995 • 639 citations

The biochemical basis of the NADPH oxidase of phagocytes

1993 • 631 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

A role for Rac in Tiaml-induced membrane ruffling and invasion

1995 • 562 citations

Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate

1996 • 522 citations

p160^ROCK, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions

1997 • 510 citations

The Dbl family of oncogenes

1996 • 497 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly

1995 • 443 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Direct Interaction of the Rho GDP Dissociation Inhibitor with Ezrin/Radixin/Moesin Initiates the Activation of the Rho Small G Protein

1997 • 424 citations

Nonsyndromic Deafness DFNA1 Associated with Mutation of a Human Homolog of the Drosophila Gene diaphanous

1997 • 409 citations

Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott–Aldrich syndrome

1996 • 397 citations

Intracellular localization of the P21rho proteins.

1992 • 382 citations

Role of Actin Polymerization and Adhesion to Extracellular Matrix in Rac- and Rho-induced Cytoskeletal Reorganization

1997 • 378 citations

ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction

1997 • 363 citations

Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway

1996 • 340 citations

rac1 Regulates a Cytokine-Stimulated, Redox-Dependent Pathway Necessary for NF-κB Activation

1996 • 337 citations

Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins

1997 • 303 citations

RAC Regulation of Actin Polymerization and Proliferation by a Pathway Distinct from Jun Kinase

1996 • 264 citations

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

1996 • 253 citations

Pheromone signalling and polarized morphogenesis in yeast

1997 • 221 citations

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1996 • 209 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis.

1997 • 200 citations

Mammalian Cdc42 Is a Brefeldin A-sensitive Component of the Golgi Apparatus

1996 • 200 citations

Regulation of Actin Polymerization in Cell-free Systems by GTPγS and Cdc42

1997 • 160 citations

Direct Involvement of the Small GTP-binding Protein Rho in lbc Oncogene Function

1995 • 156 citations

Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.

1996 • 58 citations

Cytokinesis: IQGAPs find a function

1998 • 54 citations