Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Oxidative stress: oxidants and antioxidants

1997 • 4,454 citations

The mitochondrial permeability transition

1995 • 2,412 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Intracellular Adenosine Triphosphate (ATP) Concentration: A Switch in the Decision Between Apoptosis and Necrosis

1997 • 1,851 citations

Apoptosis in the Failing Human Heart

1997 • 1,690 citations

Mechanisms by which mitochondria transport calcium

1990 • 1,630 citations

Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death.

1995 • 1,556 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria

1985 • 1,201 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

JC‐1, but not DiOC₆(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨ changes in intact cells: implications for studies on mitochondrial functionality during apoptosis

1997 • 982 citations

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

1988 • 846 citations

Mitochondrial non-specific pores remain closed during cardiac ischaemia, but open upon reperfusion

1995 • 830 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 826 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

The Ca2+-induced membrane transition in mitochondria

1979 • 751 citations

Inhibition of Ca2+-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adenine nucleotide translocase

1990 • 738 citations

Transport of lactate and other monocarboxylates across mammalian plasma membranes

1993 • 736 citations

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

1989 • 699 citations

Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.

1992 • 692 citations

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

1976 • 656 citations

The Central Executioner of Apoptosis: Multiple Connections between Protease Activation and Mitochondria in Fas/APO-1/CD95- and Ceramide-induced Apoptosis

1997 • 625 citations

The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH

1985 • 612 citations

Oxidative Stress, Thiol Reagents, and Membrane Potential Modulate the Mitochondrial Permeability Transition by Affecting Nucleotide Binding to the Adenine Nucleotide Translocase

1997 • 588 citations

Protection by Cyclosporin A of Ischemia/Reperfusion-Induced Damage in Isolated Rat Hearts

1993 • 571 citations

Recent progress on regulation of the mitochondrial permeability transition pore; a cyclosporin-sensitive pore in the inner mitochondrial membrane

1994 • 561 citations

The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents

1994 • 527 citations

Modulation of the Mitochondrial Permeability Transition Pore by Pyridine Nucleotides and Dithiol Oxidation at Two Separate Sites

1996 • 522 citations

Acute Myocardial Infarction in Humans is Associated with Activation of Programmed Myocyte Cell Death in the Surviving Portion of the Heart

1996 • 515 citations

Interactions of Cyclophilin with the Mitochondrial Inner Membrane and Regulation of the Permeability Transition Pore, a Cyclosporin A-sensitive Channel

1996 • 460 citations

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations.

1992 • 449 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization.

1992 • 443 citations

Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

1996 • 440 citations

Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury

1997 • 422 citations

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca²⁺

1996 • 421 citations

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system

1997 • 388 citations

Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide

1995 • 384 citations

Propofol

1995 • 372 citations

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A

1991 • 368 citations

Protons in ischemia: Where do they come from; Where do they go to?

1991 • 343 citations

Mitochondrial permeability transition in hepatocytes induced by t-BuOOH: NAD(P)H and reactive oxygen species

1997 • 336 citations

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore

1996 • 336 citations

Untitled

1997 • 328 citations

Physiological effectors modify voltage sensing by the cyclosporin A-sensitive permeability transition pore of mitochondria.

1993 • 315 citations

p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes.

1997 • 310 citations

The Shape of Cell Death

1997 • 302 citations

[30] The isolation of outer and inner mitochondrial membranes

1974 • 300 citations

Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition

1993 • 294 citations

Oral Sulfonylurea Hypoglycemic Agents Prevent Ischemic Preconditioning in Human Myocardium

1997 • 289 citations

Extracellular acidosis delays onset of cell death in ATP-depleted hepatocytes

1988 • 265 citations

The ADP-ATP Translocation in mitochondria, a membrane potential controlled transport

1980 • 262 citations

Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2.

1994 • 262 citations

Inhibition of anoxia-induced injury in heart myocytes by cyclosporin A

1991 • 261 citations

Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

1989 • 252 citations

Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts

1996 • 251 citations

Immunophilins in protein folding and immunosuppression ¹

1994 • 247 citations

Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

1994 • 245 citations

Peptidylproline cis/trans isomerases

1995 • 235 citations

The Mitochondrial Permeability Transition Pore is Modulated by Oxidative Agents Through Both Pyridine Nucleotides and Glutathione at Two Separate Sites

1996 • 233 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. II. The minimal requirements for pore induction underscore a key role for transmembrane electrical potential, matrix pH, and matrix Ca2+.

1993 • 225 citations

Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases

1995 • 224 citations

Pyruvate‐enhanced phosphorylation potential and inotropism in normoxic and postischemic isolated working heart

1989 • 223 citations

Further evidence that cyclosporin A protects mitochondria from calcium overload by inhibiting a matrix peptidyl-prolyl cis-trans isomerase. Implications for the immunosuppressive and toxic effects of cyclosporin

1991 • 217 citations

Regulation of the permeability transition pore, a voltage-dependent mitochondrial channel inhibited by cyclosporin A

1994 • 208 citations

Energy Metabolism during Apoptosis

1997 • 206 citations

The Conversion of Xanthine Dehydrogenase to Xanthine Oxidase and the Role of the Enzyme in Reperfusion Injury1

1994 • 203 citations

Release of Cytochrome c from Liver Mitochondria during Permeability Transition

1997 • 197 citations

Role of the Mitochondrial Permeability Transition Pore in Apoptosis

1997 • 196 citations

Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the existence of a distinct mitochondrial cyclophilin

1992 • 189 citations

The cyclophilin multigene family of peptidyl-prolyl isomerases. Characterization of three separate human isoforms.

1991 • 187 citations

Involvement of the ADPATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: Importance of the orientation of the nucleotide binding site

1988 • 186 citations

Ionic basis of ischaemic cardiac injury: insights from cellular studies

1994 • 185 citations

Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation

1993 • 181 citations

On the Voltage Dependence of the Mitochondrial Permeability Transition Pore

1997 • 179 citations

Effects of metabolic acidosis on viability of cells exposed to anoxia

1985 • 179 citations

Relation of mitochondrial and cytosolic free calcium to cardiac myocyte recovery after exposure to anoxia.

1992 • 177 citations

Is a High Glycogen Content Beneficial or Detrimental to the Ischemic Rat Heart?

1996 • 170 citations

Mechanisms of pHi recovery after global ischemia in the perfused heart.

1993 • 165 citations

Specificity and Properties of Propofol as an Antioxidant Free Radical Scavenger

1994 • 164 citations

Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox

1991 • 152 citations

Calcium-dependent opening of a non-specific pore in the mitochondrial inner membrane is inhibited at pH values below 7. Implications for the protective effect of low pH against chemical and hypoxic cell damage

1991 • 149 citations

Electrophysiology of the inner mitochondrial membrane

1994 • 147 citations

The permeability transition in heart mitochondria is regulated synergistically by ADP and cyclosporin A.

1992 • 146 citations

Propofol Attenuates Hydrogen Peroxide-induced Mechanical and Metabolic Derangements in the Isolated Rat Heart

1996 • 145 citations

Intracellular pH and Ca2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes

1993 • 138 citations

Mechanisms of Ischemic Preconditioning in Rat Myocardium

1995 • 135 citations

Dependence of hypoxic cellular calcium loading on Na(+)-Ca2+ exchange.

1992 • 131 citations

The role of neutrophils and free radicals in the ischemic-reperfused heart: Why the confusion and controversy?

1989 • 129 citations

Cyclosporine induces neuronal apoptosis and selective oligodendrocyte death in cortical cultures

1996 • 128 citations

Apoptosis in the heart: when and why?

1996 • 125 citations

Characterization of cysteine residues of mitochondrial ADP/ATP carrier with the SH-reagents eosin 5-maleimide and N-ethylmaleimide.

1993 • 124 citations

Differential Effects of Etomidate, Propofol, and Midazolam on Calcium and Potassium Channel Currents in Canine Myocardial Cells

1996 • 122 citations

Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria

1991 • 114 citations

Magnesium-Ion Modulates the Sensitivity of the Mitochondrial Permeability Transition Pore to Cyclosporine-A and ADP

1994 • 110 citations

Translocation of Loops Regulates Transport Activity of Mitochondrial ADP/ATP Carrier Deduced from Formation of a Specific Intermolecular Disulfide Bridge Catalyzed by Copper-o-Phenanthroline

1995 • 106 citations

Mitochondrial function in the oxygen depleted and reoxygenated myocardial cell

1994 • 105 citations

Chaotropic Agents and Increased Matrix Volume Enhance Binding of Mitochondrial Cyclophilin to the Inner Mitochondrial Membrane and Sensitize the Mitochondrial Permeability Transition to [Ca²⁺]

1996 • 105 citations

Dissociation between contractile function and oxidative metabolism in postischemic myocardium. Attenuation by ruthenium red administered during reperfusion.

1992 • 101 citations

Lactate Transport in Heart in Relation to Myocardial Ischemia

1997 • 100 citations

Ischemic Preconditioning is Mediated by a Peripheral Opioid Receptor Mechanism in the Intact Rat Heart

1997 • 98 citations

Measurement of mitochondrial calcium in single living cardiomyocytes by selective removal of cytosolic indo 1

1997 • 96 citations

The effects of ruthenium red on mitochondrial function during post-ischaemic reperfusion

1982 • 95 citations

The effect of propofol anaesthesia on free radical-induced lipid peroxidation in rat liver microsomes.

1993 • 87 citations

Is Lactate-induced Myocardial Ischaemic Injury Mediated by Decreased pH or Increased Intracellular Lactate?

1995 • 84 citations

Comparison of ADP and ATP as substrates for the adenine nucleotide translocator in rat-liver mitochondria

1973 • 80 citations

Ca2+ depletion prevents anoxic death of hepatocytes by inhibiting mitochondrial permeability transition

1995 • 79 citations

Electrophoretic control of reconstituted adenine nucleotide translocation

1982 • 75 citations

Effects of a New Na+/H+ Antiporter Inhibitor on Postischemic Reperfusion in Pig Heart

1994 • 74 citations

Nonenzymatic decarboxylation of pyruvate

1984 • 74 citations

Effects of the anaesthetic propofol on the calcium‐induced permeability transition of rat heart mitochondria: direct pore inhibition and shift of the gating potential

1995 • 73 citations

cDNA cloning of rat mitochondrial cyclophilin

1997 • 73 citations

Mitochondrial calcium handling and oxidative stress

1993 • 73 citations

Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1c receptor activation and independently by PKC

1993 • 71 citations

Importance of Loops of Mitochondrial ADP/ATP Carrier for Its Transport Activity Deduced from Reactivities of its Cysteine Residues with the Sulfhydryl Reagent Eosin-5-maleimide

1994 • 68 citations

Effect of Reversible Ischemia on the Activity of the Mitochondrial ATPase: Relationship to Ischemic Preconditioning

1996 • 68 citations

Preconditioning preserves mitochondrial function and glycolytic flux during an early period of reperfusion in perfused rat hearts

1997 • 66 citations

Hypoxia-reoxygenation induced increase in cellular Ca2+ in myocytes and perfused hearts: the role of mitochondria

1989 • 66 citations

Mitogen-activated protein kinase translocates to the nucleus during ischaemia and is activated during reperfusion

1997 • 65 citations

Improvement of Mitochondrial Energy Production in Ischemic Myocardium by in Vivo Infusion of Ruthenium Reb

1980 • 64 citations

Activity of the Mitochondrial Multiple Conductance Channel Is Independent of the Adenine Nucleotide Translocator

1996 • 63 citations

Comparative Effects of Na+/H+ Exchange Inhibitors Against Cardiac Injury Produced by Ischemia/Reperfusion, Hypoxia/Reoxygenation, and the Calcium Paradox

1993 • 61 citations

Cyclosporin A, an Immunosuppressive Drug, Induces Programmed Cell Death in Rat C6 Glioma Cells by a Mechanism that Involves the AP‐1 Transcription Factor

1997 • 60 citations

The protective action of pyruvate on recovery of ischemic rat heart: Comparison with other oxidizable substrates

1990 • 53 citations

Evidence for the Involvement of a Membrane‐Associated Cyclosporin‐A‐Binding Protein in the Ca²⁺‐Activated Inner Membrane Pore of Heart Mitochondria

1995 • 53 citations

Postischaemic reperfusion injury in the isolated rat heart: effect of ruthenium red

1991 • 51 citations

Influence of the Redox State of Pyridine Nucleotides on Mitochondrial Sulfhydryl Groups and Permeability Transition

1997 • 51 citations

Regulation of intracellular pH in the myocardium; relevance to pathology

1989 • 51 citations

Role for the Na+/H+ Exchanger in Reperfusion Stunning in Isolated Perfused Rat Heart

1993 • 48 citations

On the interactions of Ca2+ and cyclosporin A with a mitochondrial inner membrane pore: a study using cobaltammine complex inhibitors of the Ca2+ uniporter

1994 • 46 citations

Effects of the general anaesthetic Propofol on the Ca²⁺‐induced permeabilization of rat liver mitochondria

1991 • 45 citations

Ruthenium Red Improves Postischemic Contractile Function in Isolated Rat Hearts

1990 • 45 citations

Myocardial stunning: a role for calcium antagonists during reperfusion?

1992 • 44 citations

Propofol induces a lowering of free cytosolic calcium in myocardial cells

1997 • 44 citations

Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function

1992 • 43 citations

Apoptosis in the Heart

1997 • 42 citations

Inhibition of Rat Liver Mitochondrial Permeability Transition by Respiratory Substrates

1995 • 40 citations

Ischemic preconditioning

1997 • 39 citations

Evidence for the Involvement of a Membrane-Associated Cyclosporin-A-Binding Protein in the Ca2+-Activated Inner Membrane Pore of Heart Mitochondria

1995 • 38 citations

Protection of the myocardium by ischaemic preconditioning: Mechanisms and therapeutic implications

1996 • 37 citations

Cardioprotection by Cyclosporine A in Experimental Ischemia and Reperfusion—Evidence for a Nitric Oxide-dependent Mechanism Mediated by Endothelin

1997 • 37 citations

An ADP‐sensitive cyclosporin‐A‐binding protein in rat liver mitochondria

1994 • 36 citations

Protection of energy status of hypoxic cardiomyocytes by mild acidosis

1992 • 35 citations

Effects of pyruvate on post-ischemic myocardial recovery at various workloads

1988 • 27 citations

Preischaemic as well as postischaemic application of a calcium antagonist affords cardioprotection in the isolated guinea pig heart.

1995 • 22 citations

Augmentation of Apoptosis in Bronchial Exuded Rat Eosinophils by Cyclosporin A

1996 • 17 citations

Inhibitory effect of pyruvate on release of glutathione and swelling of rat heart mitochondria

1995 • 15 citations

Mitochondrial Ca2+ fluxes and levels during ischaemia and reperfusion: Possible mechanisms

1987 • 12 citations

Calcium and the heart

1990 • 8 citations

Preischaemic as well as postischaemic application of a calcium antagonist affords cardioprotection in the isolated guinea pig heart

1995 • 7 citations