Rapid targeting of nuclear proteins to the cytoplasm

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

Inositol trisphosphate and calcium signalling

1993 • 6,546 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

A molecular mechanism for the effect of lithium on development.

1996 • 2,270 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Differential activation of transcription factors induced by Ca2+ response amplitude and duration

1997 • 1,533 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

Identification of a signal for rapid export of proteins from the nucleus

1995 • 1,186 citations

The HIV-1 Rev Activation Domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

1995 • 1,127 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Controlling Signal Transduction with Synthetic Ligands

1993 • 815 citations

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

1997 • 754 citations

Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

1990 • 699 citations

NF-AT components define a family of transcription factors targeted in T-cell activation

1994 • 573 citations

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

1995 • 547 citations

Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression

1996 • 535 citations

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction.

1997 • 403 citations

The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells.

1990 • 360 citations

Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

1995 • 347 citations

HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.

1991 • 307 citations

Mutational definition of the human immunodeficiency virus type 1 Rev activation domain

1991 • 276 citations

Controlling protein association and subcellular localization with a synthetic ligand that induces heterodimerization of proteins.

1996 • 275 citations

Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene

1995 • 258 citations

Dimeric ligands define a role for transcriptional activation domains in reinitiation

1996 • 257 citations

Nuclear export signals and the fast track to the cytoplasm

1995 • 229 citations

Nuclear export of proteins: The role of nuclear retention

1993 • 209 citations

Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor alpha gene promoter.

1993 • 202 citations

Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter

1993 • 191 citations

A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.

1996 • 155 citations

Human Granulocyte-Macrophage Colony-Stimulating Factor Enhancer Function Is Associated with Cooperative Interactions between AP-1 and NFATp/c

1995 • 133 citations

Signal transduction in T lymphocytes using a conditional allele of Sos.

1995 • 131 citations

Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev.

1996 • 110 citations

HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs

1996 • 106 citations

Characterization of the Nuclear Export Signal of Human T-Cell Lymphotropic Virus Type 1 Rex Reveals that Nuclear Export Is Mediated by Position-Variable Hydrophobic Interactions

1996 • 96 citations

A general strategy for producing conditional alleles of Src-like tyrosine kinases.

1995 • 77 citations

Protein translocation: Nuclear export – out of the dark

1996 • 20 citations