Induction of NFAT-mediated Transcription by Gq-coupled Receptors in Lymphoid and Non-lymphoid Cells

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation

1992 • 1,634 citations

Identification of a Family of Muscarinic Acetylcholine Receptor Genes

1987 • 1,439 citations

Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

1991 • 1,054 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

1992 • 865 citations

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

1993 • 702 citations

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes

1994 • 523 citations

Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins

1995 • 383 citations

Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.

1993 • 344 citations

NF-ATp, a T lymphocyte DNA-binding protein that is a target for calcineurin and immunosuppressive drugs.

1993 • 293 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein

1994 • 162 citations

Stimulation of the phosphatidyl-inositol pathway can induce T-cell activation

1990 • 129 citations

Induction of NF-AT in normal B lymphocytes by anti-immunoglobulin or CD40 ligand in conjunction with IL-4

1994 • 125 citations

Cyclosporin-a sensitive induction of NF-AT in murine B cells

1994 • 124 citations

Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system.

1994 • 123 citations

Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.

1990 • 101 citations

The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

1991 • 99 citations

Regulation of granulocyte-macrophage colony-stimulating factor and E- selectin expression in endothelial cells by cyclosporin A and the T- cell transcription factor NFAT

1995 • 99 citations

Molecular structure and transcriptional function of the rat vascular AT1a angiotensin receptor gene.

1993 • 89 citations

T-Cell Antigen Receptor-Induced Signal-Transduction Pathways. Activation and Function of Protein Kinases C in T Lymphocytes

1995 • 83 citations

Nuclear Factor of Activated T Cells Is Associated with a Mast Cell Interleukin 4 Transcription Complex

1996 • 78 citations

Comparative analysis of NFAT (nuclear factor of activated T cells) complex in human T and B lymphocytes

1993 • 71 citations

A cloned angiotensin receptor isoform from the turkey adrenal gland is pharmacologically distinct from mammalian angiotensin receptors.

1993 • 65 citations

Function of a Heterologous Muscarinic Receptor in T Cell Antigen Receptor Signal Transduction Mutants

1989 • 58 citations

Indications for selective coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition by endogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor cell lines

1990 • 24 citations