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Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential mechanisms of synergy

Data up to Jan 2025

Published2015
Citations748
References90

Total Citations Per Year

Abstract

References (90)

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

Nivolumab plus Ipilimumab in Advanced Melanoma

2013 • 4,054 citations

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

2013 • 3,290 citations

Calreticulin exposure dictates the immunogenicity of cancer cell death

2006 • 2,789 citations

The Immunobiology of Cancer Immunosurveillance and Immunoediting

2004 • 2,788 citations

Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

2015 • 2,154 citations

Survival, Durable Tumor Remission, and Long-Term Safety in Patients With Advanced Melanoma Receiving Nivolumab

2014 • 2,071 citations

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

2012 • 1,925 citations

Cancer Immunotherapy

2013 • 1,862 citations

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

2014 • 1,846 citations

Towards a systems understanding of MHC class I and MHC class II antigen presentation

2011 • 1,673 citations

How dying cells alert the immune system to danger

2008 • 1,616 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Ipilimumab versus placebo after radiotherapy in patients with metastatic castration-resistant prostate cancer that had progressed after docetaxel chemotherapy (CA184-043): a multicentre, randomised, double-blind, phase 3 trial

2014 • 1,382 citations

Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated

2004 • 1,253 citations

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

2009 • 1,232 citations

Decisions About Dendritic Cells: Past, Present, and Future

2012 • 1,165 citations

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

2014 • 1,120 citations

Whole Body Irradiation—Radiobiology or Medicine?

1953 • 1,004 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

2013 • 834 citations

Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

2003 • 787 citations

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon–Dependent Innate and Adaptive Immunity

2011 • 773 citations

Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells

2008 • 650 citations

An Abscopal Response to Radiation and Ipilimumab in a Patient with Metastatic Non–Small Cell Lung Cancer

2013 • 644 citations

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1–Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

2014 • 578 citations

HMGB1 is an endogenous immune adjuvant released by necrotic cells

2004 • 576 citations

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans

2013 • 570 citations

Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes

2004 • 532 citations

Maximizing Tumor Immunity With Fractionated Radiation

2011 • 503 citations

Radiation and ceramide-induced apoptosis

2003 • 487 citations

Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.

1989 • 473 citations

Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy

2003 • 452 citations

Radiotherapy Promotes Tumor-Specific Effector CD8+ T Cells via Dendritic Cell Activation

2012 • 396 citations

Clinical Radiation Oncology

2016 • 386 citations

Radiation Enhances Regulatory T Cell Representation

2010 • 368 citations

[Whole body irradiation].

1992 • 364 citations

Stereotactic Radiosurgery for Melanoma Brain Metastases in Patients Receiving Ipilimumab: Safety Profile and Efficacy of Combined Treatment

2015 • 359 citations

PD-1 Restrains Radiotherapy-Induced Abscopal Effect

2015 • 353 citations

Radiation-induced immunogenic modulation of tumor enhances antigen processing and calreticulin exposure, resulting in enhanced T-cell killing

2013 • 352 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

Radiation as an immunological adjuvant: current evidence on dose and fractionation

2012 • 302 citations

HMGB1 as a DNA-binding cytokine

2002 • 297 citations

Cell adhesion molecules mediate radiation-induced leukocyte adhesion to the vascular endothelium.

1996 • 296 citations

Chemotherapeutics and Radiation Stimulate MHC Class I Expression through Elevated Interferon-beta Signaling in Breast Cancer Cells

2012 • 251 citations

Radiation abscopal antitumor effect is mediated through p53.

2003 • 243 citations

Effect of Host Immune Capability on Radiocurability and Subsequent Transplantability of a Murine Fibrosarcoma<xref ref-type="fn" rid="FN2">2</xref>

1979 • 236 citations

Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

2014 • 227 citations

TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer CellsIn Vitroand Promotes Tumor Control by RadiationIn Vivo

2011 • 226 citations

Regulatory T-cell Modulation Using Cyclophosphamide in Vaccine Approaches: A Current Perspective

2012 • 212 citations

Immune Modulation by Ionizing Radiation and its Implications for Cancer Immunotherapy

2002 • 200 citations

Increase of NKG2D ligands and sensitivity to NK cell-mediated cytotoxicity of tumor cells by heat shock and ionizing radiation

2006 • 175 citations

Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation

1999 • 162 citations

The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology

2011 • 158 citations

Up-regulation of the Pro-inflammatory Chemokine CXCL16 is a Common Response of Tumor Cells to Ionizing Radiation

2010 • 153 citations

Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model

2009 • 153 citations

The radiation abscopal anti-tumor effect is mediated through p53

2002 • 151 citations

Immunotherapy earns its spot in the ranks of cancer therapy

2012 • 135 citations

Review of image-guided radiation therapy

2006 • 132 citations

Immune privilege or privileged immunity?

2008 • 130 citations

Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming

2005 • 119 citations

IFN-γ Mediates the Antitumor Effects of Radiation Therapy in a Murine Colon Tumor

2013 • 115 citations

Radiotherapy-Induced Anti-Tumor Immunity Contributes to the Therapeutic Efficacy of Irradiation and Can Be Augmented by CTLA-4 Blockade in a Mouse Model

2014 • 115 citations

Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells.

2000 • 95 citations

Chemoradiotherapy-Induced Upregulation of PD-1 Antagonizes Immunity to HPV-Related Oropharyngeal Cancer

2014 • 95 citations

Induction of the Expression of the Interleukin-1β Gene in Mouse Spleen by Ionizing Radiation

1993 • 91 citations

Immunological tolerance: Danger – pathogen on the premises!

1996 • 86 citations

Radiotherapy augments the immune response to prostate cancer in a time‐dependent manner

2008 • 85 citations

Radiation-Induced Modulation of Costimulatory and Coinhibitory T-Cell Signaling Molecules on Human Prostate Carcinoma Cells Promotes Productive Antitumor Immune Interactions

2014 • 79 citations

Clinical Radiation Oncology

2012 • 78 citations

Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer

2002 • 75 citations

The effects of therapeutic irradiation on lymphocytes and immunity

1977 • 68 citations

Radiation-enhanced expression of major histocompatibility complex class I antigen H-2Db in B16 melanoma cells.

1993 • 65 citations

Identification and management of toxicities from immune checkpoint-blocking drugs.

2014 • 57 citations

Thorax irradiation triggers a local and systemic accumulation of immunosuppressive CD4+ FoxP3+ regulatory T cells

2014 • 57 citations

Survival, safety, and response duration results of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in a phase I trial in patients with previously treated metastatic renal cell carcinoma (mRCC): Long-term patient follow-up.

2013 • 56 citations

Selective Changes in the Immune Profile of Tumor-Draining Lymph Nodes After Different Neoadjuvant Chemoradiation Regimens for Locally Advanced Cervical Cancer

2010 • 49 citations

TGFβ Inhibition Prior to Hypofractionated Radiation Enhances Efficacy in Preclinical Models

2014 • 48 citations

Induction of Apoptosis through the Activation of SAPK/JNK Followed by the Expression of Death Receptor Fas in X-irradiated Cells

2003 • 46 citations

PD-L1hi retinal pigment epithelium (RPE) cells elicited by inflammatory cytokines induce regulatory activity in uveitogenic T cells

2010 • 32 citations

Characterization of direct radiation-induced immune function and molecular signaling changes in an antigen presenting cell line

2013 • 31 citations

The Curative Outcome of Radioimmunotherapy in a Mouse Breast Cancer Model Relies on mTOR Signaling

2014 • 30 citations

Age Dependence of Hematopoietic Progenitor Survival and Chemokine Family Gene Induction after Gamma Irradiation in Bone Marrow Tissue in C3H/He Mice

2014 • 20 citations

Radiation-Induced Immune Modulation

2011 • 16 citations

[Antitumoral action of interferons and interleukins in combination with radiotherapy. Part I: immunologic basis].

2004 • 10 citations

Antitumorale Wirkung von Interferonen und Interleukinen in Kombination mit Strahlentherapie

2004 • 8 citations

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Radiation and checkpoint blockade immunotherapy: radiosensitisation and potential… (2015) – The Lancet Oncology | Metascience Observatory Explorer