Induction of Apoptosis through the Activation of SAPK/JNK Followed by the Expression of Death Receptor Fas in X-irradiated Cells

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1995 • 4,043 citations

BCL-2 family members and the mitochondria in apoptosis

1999 • 3,657 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

2000 • 1,033 citations

The p53 Network

1998 • 731 citations

Differential Modulation of Apoptosis Sensitivity in CD95 Type I and Type II Cells

1999 • 595 citations

Role for Ceramide in Cell Cycle Arrest

1995 • 488 citations

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

1998 • 421 citations

Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis

2000 • 283 citations

Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-α in Rat Mesangial Cells

1998 • 262 citations

Stress-induced apoptosis and the sphingomyelin pathway

1997 • 234 citations

Nuclear and mitochondrial apoptotic pathways of p53

2001 • 225 citations

c-Jun NH2-terminal Kinase-mediated Activation of Interleukin-1β Converting Enzyme/CED-3-like Protease during Anticancer Drug-induced Apoptosis

1997 • 207 citations

Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.

2000 • 206 citations

The p53 gene as a modifier of intrinsic radiosensitivity: implications for radiotherapy

1996 • 195 citations

Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation

1992 • 161 citations

The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation

1994 • 152 citations

Apoptosis: checkpoint at the mitochondrial frontier

1999 • 152 citations

Regulation of the human fas promoter by YB-1, Purα and AP-1 transcription factors

2000 • 131 citations

Requirement of ATM in Phosphorylation of the Human p53 Protein at Serine 15 following DNA Double-Strand Breaks

1999 • 128 citations

Radiation-induced apoptosis in a murine T-cell hybridoma.

1992 • 116 citations

Trolox inhibits apoptosis in irradiated MOLT‐4 lymphocytes

1995 • 89 citations

Radiation-induced Apoptosis and Necrosis in Molt-4 Cells: A Study of Dose-effect Relationships and Their Modification

1993 • 84 citations

A Role for Calcium in Regulating Apoptosis in Rat Thymocytes Irradiatedin Vitro

1992 • 82 citations

Characterization of the mouse and human PRSS17 genes, their relationship to other serine proteases, and the expression of PRSS17 in developing mouse incisors

2000 • 80 citations

Mitochondrial and intracellular free-calcium regulation of radiation-induced apoptosis in human leukemic cells

1999 • 70 citations

Radiation-induced DNA double-strand breaks and the radiosensitivity of human cells: A closer look

1997 • 64 citations

X-Ray-Induced Cell Death: Apoptosis and Necrosis

1994 • 61 citations

Alternative splicing of the p53 tumor suppressor gene in the Molt-4 T-lymphoblastic leukemia cell line

1993 • 60 citations

cAMP increasing agents attenuate the generation of apoptosis by etoposide in promonocytic leukemia cells

1998 • 57 citations

Effects of BAPTA‐AM and Forskolin on Apoptosis and Cytochrome c Release in Photosensitized Chinese Hamster V79 Cells

1999 • 52 citations

Down regulation of bcl‐2 by p53 in nasopharyngeal carcinoma and lack of detection of its specific t(14;18) chromosomal translocation in fixed tissues

1996 • 51 citations

Attenuation of caspase-3-dependent apoptosis by Trolox post-treatment of X-irradiated MOLT-4 cells

1999 • 50 citations

2-Chloro-2′-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4

2000 • 50 citations

Roles of Protein Kinase C δ in the Accumulation of P53 and the Induction of Apoptosis in H 2 O 2 -treated Bovine Endothelial Cells

2002 • 49 citations

c-Jun NH2-terminal Kinase Activation Leads to a FADD-dependent but Fas Ligand-independent Cell Death in Jurkat T Cells

2001 • 47 citations

Interphase death and reproductive death in X-irradiated MOLT-4 cells.

1993 • 46 citations

DNA damage-related gene expression as biomarkers to assess cellular response after gamma irradiation of a human lymphoblastoid cell line

2000 • 45 citations

Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor·CD3 Complex-stimulated T Cells

1999 • 45 citations

H₂O₂ induces upregulation of Fas and Fas ligand expression in NGF‐differentiated PC12 cells: Modulation by cAMP

2002 • 43 citations

Modification of potentially lethal damage in irradiated Chinese hamster V79 cells after incorporation of halogenated pyrimidines

1997 • 43 citations

Pre-irradiation at a Low Dose-rate Blunted p53 Response

2002 • 41 citations

Two pathways for the induction of apoptosis in human lymphocytes

1999 • 40 citations

Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4

2000 • 35 citations

Evaluation of the relative contribution of p53-mediated pathway in X-ray-induced apoptosis in human leukemic MOLT-4 cells by transfection with a mutant p53 gene at different expression levels

2001 • 34 citations

Mechanism of radiosensitization by halogenated pyrimidines: effect of BrdU on cell killing and interphase chromosome breakage in radiation-sensitive cells.

1991 • 34 citations

Effects of intracellular calcium chelator BAPTA-AM on radiation-induced apoptosis regulated by activation of SAPK/JNK and caspase-3 in MOLT-4 cells

1999 • 33 citations

Interphase Death and Reproductive Death in X-Irradiated MOLT-4 Cells

1993 • 33 citations

Modulating Ca2 in radiation-induced apoptosis suppresses DNA fragmentation but does not enhance clonogenic survival

1997 • 32 citations

Elevation of Intracellular Calcium Ions Is Essential for the H₂O₂-Induced Activation of SAPK/JNK but Not for That of p38 and ERK in Chinese Hamster V79 Cells

1999 • 30 citations

Inhibition of Apoptosis After Ischemia-reperfusion in Rat Myocardium by Cycloheximide

1999 • 28 citations

Protein synthesis-dependent apoptotic signalling pathway in X-irradiated MOLT-4 human leukaemia cell line

2002 • 26 citations

Hydrogen Peroxide-Induced Activation of SAPK/JNK Regulated by Phosphatidylinositol 3-Kinase in Chinese Hamster V79 Cells

1999 • 22 citations

Mechanism of Radiosensitization by Halogenated Pyrimidines: Effect of BrdU on Cell Killing and Interphase Chromosome Breakage in Radiation-Sensitive Cells

1991 • 21 citations

Induction of apoptosis and cell cycle-specific change in expression of p53 in normal lymphocytes and MOLT-4 leukemic cells by nitrogen mustard.

1995 • 17 citations

Radiation‐induced apoptosis in MOLT‐4 cells requires de novo protein synthesis independent of de novo RNA synthesis

2002 • 15 citations

Hypoxia and etanidazole alter radiation-induced apoptosis in HL60 cells but not in MOLT-4 cells

2002 • 14 citations

Radiation-chemical Properties of the Hypoxic Cell Radiosensitizer Doranidazole (PR-350)

2002 • 10 citations

Effects of BAPTA-AM and Forskolin on Apoptosis and Cytochrome c Release in Photosensitized Chinese Hamster V79 Cells

1999 • 6 citations

Protein synthesis‐dependent but Bcl‐2‐independent cytochrome C release in zinc depletion‐induced neuronal apoptosis

2000 • 4 citations