TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer CellsIn Vitroand Promotes Tumor Control by RadiationIn Vivo

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Systemic effects of local radiotherapy

2009 • 906 citations

The polarization of immune cells in the tumour environment by TGFβ

2010 • 836 citations

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

2000 • 626 citations

Gene expression profiling of breast cell lines identifies potential new basal markers

2005 • 556 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Inhibition of TGF-β with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression

2007 • 333 citations

Monoclonal antibodies recognizing transforming growth factor-beta. Bioactivity neutralization and transforming growth factor beta 2 affinity purification.

1989 • 307 citations

C/EBPβ at the core of the TGFβ cytostatic response and its evasion in metastatic breast cancer cells

2006 • 268 citations

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

2007 • 257 citations

Isoform-Specific Activation of Latent Transforming Growth Factor β (LTGF-β) by Reactive Oxygen Species

2006 • 256 citations

Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17

2008 • 232 citations

Alterations of Smad signaling in human breast carcinoma are associated with poor outcome: a tissue microarray study.

2002 • 219 citations

An Anti–Transforming Growth Factor β Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments

2008 • 219 citations

Amelioration of Radiation-induced Fibrosis

2004 • 192 citations

Malignant cells, directors of the malignant process: role of transforming growth factor-beta.

2001 • 180 citations

Interference with Transforming Growth Factor-β/ Smad3 Signaling Results in Accelerated Healing of Wounds in Previously Irradiated Skin

2003 • 165 citations

Targeting the Transforming Growth Factor-β pathway inhibits human basal-like breast cancer metastasis

2010 • 163 citations

Ionizing Radiation Predisposes Nonmalignant Human Mammary Epithelial Cells to Undergo Transforming Growth Factor β–Induced Epithelial to Mesenchymal Transition

2007 • 159 citations

Inhibition of Transforming Growth Factor-β1 Signaling Attenuates Ataxia Telangiectasia Mutated Activity in Response to Genotoxic Stress

2006 • 156 citations

Inhibition of Growth and Metastasis of Mouse Mammary Carcinoma by Selective Inhibitor of Transforming Growth Factor-β Type I Receptor KinaseIn vivo

2006 • 149 citations

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

2002 • 141 citations

Small Molecular Inhibitor of Transforming Growth Factor-β Protects Against Development of Radiation-Induced Lung Injury

2008 • 126 citations

Antitransforming growth factor–β antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation

2006 • 124 citations

TGF Beta Inhibition for Cancer Therapy

2006 • 118 citations

Anti–Transforming Growth Factor β Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

2010 • 115 citations

Mammographic density, lobular involution, and risk of breast cancer

2008 • 104 citations

The predictive role of plasma TGF-β1 during radiation therapy for radiation-induced lung toxicity deserves further study in patients with non-small cell lung cancer

2007 • 93 citations

Trimodal Glioblastoma Treatment Consisting of Concurrent Radiotherapy, Temozolomide, and the Novel TGF-β Receptor I Kinase Inhibitor LY2109761

2011 • 91 citations

Blockade of Tumor Cell Transforming Growth Factor-βs Enhances Cell Cycle Progression and Sensitizes Human Breast Carcinoma Cells to Cytotoxic Chemotherapy

1998 • 84 citations

IR-inducible clusterin gene expression: a protein with potential roles in ionizing radiation-induced adaptive responses, genomic instability, and bystander effects

2004 • 81 citations

Levels of γ-H2AX Foci after Low-Dose-Rate Irradiation Reveal a DNA DSB Rejoining Defect in Cells from HumanATMHeterozygotes in Two AT Families and in Another Apparently Normal Individual

2006 • 70 citations

Transforming Growth Factor-β Receptor Inhibition Enhances Adenoviral Infectability of Carcinoma Cells via Up-Regulation of Coxsackie and Adenovirus Receptor in Conjunction with Reversal of Epithelial-Mesenchymal Transition

2006 • 70 citations

Normal tissue injury after cancer therapy is a local response exacerbated by an endocrine effect of TGFβ

1995 • 67 citations

Soluble TGFβ TYPE II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats

2003 • 66 citations

Large- and small-molecule inhibitors of transforming growth factor-beta signaling.

2006 • 65 citations

Multiple Signaling Pathways Involving ATM

2000 • 54 citations

The not-so innocent bystander: the microenvironment as a therapeutic target in cancer

2003 • 49 citations

Checkpoint signaling: Epigenetic events sound the DNA strand‐breaks alarm to the ATM protein kinase

2003 • 48 citations

TGFβ-1 dependent fast stimulation of ATM and p53 phosphorylation following exposure to ionizing radiation does not involve TGFβ-receptor I signalling

2007 • 46 citations

Transforming growth factor-β in in vivo resistance

1996 • 46 citations

Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin.

1998 • 42 citations

Radiotherapy: what can be achieved by technical improvements in dose delivery?

2005 • 40 citations

Transforming growth factor-beta and response to anticancer therapies in human liver and gastric tumors in vitro and in vivo.

2000 • 36 citations

Radiotherapy: what can be achieved by technical improvements in dose delivery?

2005 • 33 citations

Lack of Radiation Dose or Quality Dependence of Epithelial-to-Mesenchymal Transition (EMT) Mediated by Transforming Growth Factor β

2011 • 31 citations

A statistical approach for analyzing clonogenic survival data.

1996 • 28 citations

A Statistical Approach for Analyzing Clonogenic Survival Data

1996 • 27 citations

Halofuginone enhances the radiation sensitivity of human tumor cell lines

2009 • 24 citations

TGFβ: Roles in DNA Damage Responses

2008 • 4 citations