Anti-CCR4 mAb selectively depletes effector-type FoxP3⁺CD4⁺regulatory T cells, evoking antitumor immune responses in humans

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

FOXP3+ regulatory T cells in the human immune system

2010 • 2,283 citations

Intraepithelial CD8⁺tumor-infiltrating lymphocytes and a high CD8⁺/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer

2005 • 2,226 citations

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

2009 • 2,107 citations

Regulatory T cells, tumour immunity and immunotherapy

2006 • 2,009 citations

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 • 1,702 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

2005 • 998 citations

Regulatory T cells in tumor immunity

2010 • 902 citations

Cancer/testis antigens: an expanding family of targets for cancer immunotherapy

2002 • 851 citations

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

2007 • 783 citations

Phenotypical and functional specialization of FOXP3+ regulatory T cells

2011 • 736 citations

Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

1999 • 710 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study

2012 • 609 citations

Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

2011 • 607 citations

Immune Therapy for Cancer

2008 • 581 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells

2012 • 462 citations

Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+regulatory T cells

2005 • 451 citations

NY‐ESO‐1: Review of an Immunogenic Tumor Antigen

2006 • 354 citations

Clinical significance of CCR4 expression in adult T-cell leukemia/lymphoma: its close association with skin involvement and unfavorable outcome.

2003 • 342 citations

Control of Immune Responses by Antigen-Specific Regulatory T Cells Expressing the Folate Receptor

2007 • 342 citations

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

2012 • 320 citations

Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1–transformed T cells

2002 • 313 citations

Inability of a Fusion Protein of IL-2 and Diphtheria Toxin (Denileukin Diftitox, DAB389IL-2, ONTAK) to Eliminate Regulatory T Lymphocytes in Patients With Melanoma

2005 • 293 citations

CCR4 as a novel molecular target for immunotherapy of cancer

2006 • 235 citations

Human Th17 Cells Share Major Trafficking Receptors with Both Polarized Effector T Cells and FOXP3+ Regulatory T Cells

2008 • 218 citations

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

2009 • 198 citations

IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity

2007 • 180 citations

In vivo antigen delivery by aSalmonella typhimurium type III secretion system for therapeutic cancer vaccines

2006 • 176 citations

CD4+ CD25+ regulatory T cells control the induction of antigen-specific CD4+ helper T cell responses in cancer patients

2005 • 169 citations

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2011 • 149 citations

Two Distinct Mechanisms of Augmented Antitumor Activity by Modulation of Immunostimulatory/Inhibitory Signals

2010 • 133 citations

Definition of target antigens for naturally occurring CD4+ CD25+ regulatory T cells

2005 • 131 citations

Induction of T cell anergy: integration of environmental cues and infectious tolerance

2010 • 125 citations

Human tumor antigens recognized by T-cells

1997 • 121 citations

Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma

2012 • 68 citations

Influence of CD4+CD25+ Regulatory T Cells on Low/High-Avidity CD4+ T Cells following Peptide Vaccination

2006 • 58 citations

Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines

2009 • 45 citations