Chemoradiotherapy-Induced Upregulation of PD-1 Antagonizes Immunity to HPV-Related Oropharyngeal Cancer

Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer

2010 • 5,874 citations

Improved Survival of Patients With Human Papillomavirus-Positive Head and Neck Squamous Cell Carcinoma in a Prospective Clinical Trial

2008 • 2,660 citations

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

2014 • 1,846 citations

Factors Associated With Severe Late Toxicity After Concurrent Chemoradiation for Locally Advanced Head and Neck Cancer: An RTOG Analysis

2008 • 1,261 citations

5-Fluorouracil Selectively Kills Tumor-Associated Myeloid-Derived Suppressor Cells Resulting in Enhanced T Cell–Dependent Antitumor Immunity

2010 • 1,119 citations

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

2013 • 834 citations

Clinical Significance of Programmed Death-1 Ligand-1 and Programmed Death-1 Ligand-2 Expression in Human Esophageal Cancer

2005 • 758 citations

Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma

2013 • 721 citations

Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral‐induced carcinoma?

2009 • 705 citations

Tumor‐induced tolerance and immune suppression by myeloid derived suppressor cells

2008 • 597 citations

PD-1–Expressing Tumor-Infiltrating T Cells Are a Favorable Prognostic Biomarker in HPV-Associated Head and Neck Cancer

2012 • 587 citations

Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial

2011 • 456 citations

The Abscopal Effect Associated With a Systemic Anti-melanoma Immune Response

2013 • 362 citations

Programmed Death Ligand 2 in Cancer-Induced Immune Suppression

2012 • 321 citations

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

2011 • 310 citations

Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.

1992 • 269 citations

Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies

2012 • 265 citations

Intratumoral regulatory T cells upregulate immunosuppressive molecules in head and neck cancer patients

2013 • 261 citations

Tumor-Expressed B7-H1 and B7-DC in Relation to PD-1+ T-Cell Infiltration and Survival of Patients with Cervical Carcinoma

2009 • 241 citations

Immune Response During Therapy With Cisplatin or Radiation for Human Papillomavirus–Related Head and Neck Cancer

2009 • 237 citations

Protein expression of programmed death 1 ligand 1 and ligand 2 independently predict poor prognosis in surgically resected lung adenocarcinoma

2014 • 207 citations

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

2012 • 201 citations

Role of T lymphocytes in tumor response to radiotherapy

2012 • 159 citations

Radiation-Induced Equilibrium Is a Balance between Tumor Cell Proliferation and T Cell–Mediated Killing

2013 • 155 citations

Association between severe treatment‐related lymphopenia and progression‐free survival in patients with newly diagnosed squamous cell head and neck cancer

2013 • 155 citations

B7-H1 Expression Model for Immune Evasion in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma

2012 • 122 citations

Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model

2009 • 113 citations

Immune Suppression in Premalignant Respiratory Papillomas: Enriched Functional CD4+Foxp3+ Regulatory T Cells and PD-1/PD-L1/L2 Expression

2012 • 102 citations

Radiation‐induced loss of cell surface CD47 enhances immune‐mediated clearance of human papillomavirus‐positive cancer

2013 • 93 citations

Targeting Tumor-Related Immunosuppression for Cancer Immunotherapy

2006 • 91 citations

HPV-induced oropharyngeal cancer, immune response and response to therapy

2009 • 80 citations

The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy

2009 • 73 citations

Induction Therapy in the Modern Era of Combined-Modality Therapy for Locally Advanced Head and Neck Cancer

2008 • 70 citations

Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancer

2012 • 68 citations

Serial studies of immunocompetence in head and neck cancer patients undergoing radiation therapy

1976 • 52 citations

Long-term immune dysfunction after radiotherapy to the head and neck area

2003 • 49 citations

Selective Changes in the Immune Profile of Tumor-Draining Lymph Nodes After Different Neoadjuvant Chemoradiation Regimens for Locally Advanced Cervical Cancer

2010 • 49 citations

Radiochemotherapy induces a favourable tumour infiltrating inflammatory cell profile in head and neck cancer

2012 • 48 citations

In SituObservation of the Effects of Local Irradiation on Cytotoxic and Regulatory T Lymphocytes in Cervical Cancer Tissue

2013 • 42 citations

Effects of Radiation Therapy on T‐Lymphocyte Subpopulations in Patients with Head and Neck Cancer

1985 • 41 citations

Neoadjuvant therapy changes the lymphocyte composition of tumor‐draining lymph nodes in cervical carcinoma

2004 • 28 citations

Cellular immune defect caused by postsurgical radiation therapy in patients with head and neck cancer

1998 • 27 citations

Decreased HPV-specific T cell responses and accumulation of immunosuppressive influences in oropharyngeal cancer patients following radical therapy

2013 • 20 citations

Increase of human papillomavirus‐16 E7‐specific T helper type 1 response in peripheral blood of cervical cancer patients after radiotherapy

2008 • 19 citations

Effects of combined immunotherapy with levamisole and Bacillus Calmette-Guérin on immunocompetence of patients with squamous cell carcinoma of the cervix, head and neck, and lung undergoing radiation therapy.

1978 • 19 citations

Effect of thymosin and irradiation on immune modulation in head and neck and esophageal cancer patients.

1978 • 13 citations

Amifostine Modulates Radio-induced Apoptosis of Peripheral Blood Lymphocytes in Head and Neck Cancer Patients

2010 • 10 citations