Sub-lethal radiation enhances anti-tumor immunotherapy in a transgenic mouse model of pancreatic cancer

Dendritic cells and the control of immunity

1998 • 14,345 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

1996 • 1,281 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

1996 • 917 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

2000 • 723 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

The role of CD4+ T cell responses in antitumor immunity

1998 • 678 citations

Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression.

1995 • 552 citations

CD4 + T Cell–Mediated Tumor Rejection Involves Inhibition of Angiogenesis that Is Dependent on IFNγ Receptor Expression by Nonhematopoietic Cells

2000 • 505 citations

During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium

1996 • 449 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

Cancer vaccines based on the identification of genes encoding cancer regression antigens

1997 • 395 citations

B cells inhibit induction of T cell-dependent tumor immunity

1998 • 393 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow–derived Antigen-presenting Cells

1998 • 300 citations

Human tumor antigens for cancer vaccine development

1999 • 298 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

1996 • 235 citations

Cell injury releases endogenous adjuvants that stimulate cytotoxic T cell responses

2000 • 227 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Adoptive cellular immunotherapy for EBV lymphoproliferative diseases

1997 • 212 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

Delivery of molecular and cellular medicine to solid tumors

1998 • 190 citations

Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice.

1994 • 188 citations

Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance

1997 • 183 citations

Diminished leukocyte-endothelium interaction in tumor microvessels.

1992 • 162 citations

Building better vaccines: how apoptotic cell death can induce inflammation and activate innate and adaptive immunity

2000 • 153 citations

CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes.

2000 • 148 citations

Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

1996 • 147 citations

Tumor microenvironment can restrict the effectiveness of activated antitumor lymphocytes.

1998 • 124 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Modulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic mice.

1996 • 101 citations

DIFFERENTIAL REGULATION BY IL-4 AND IL-10 OF RADIATION-INDUCED IL-6 AND IL-8 PRODUCTION AND ICAM-1 EXPRESSION BY HUMAN ENDOTHELIAL CELLS

1999 • 99 citations

Influence of gene-modified (IL-7, IL-4, and B7) tumor cell vaccines on tumor antigen presentation.

1997 • 85 citations

Peripheral tolerance of CD4 T cells following local activation in adolescent mice

1996 • 82 citations

Local Tumor Irradiation Augments the Response to IL-2 Therapy in a Murine Renal Adenocarcinoma

1995 • 56 citations

Melphalan and Other Anticancer Modalities Up-Regulate B7-1 Gene Expression in Tumor Cells

2000 • 56 citations

Immunologic Nonresponsiveness to Tumors

1998 • 54 citations

T-cell clones from melanoma patients immunized against an anchor-modified gp100 peptide display discordant effector phenotypes.

2000 • 46 citations

Effects of Irradiation on the Expression of Surface Antigens in Human Ovarian Cancer

1996 • 36 citations

Downregulation of Innate and Acquired Antitumor Immunity by Bystander gamma delta and alpha beta T Lymphocytes with Th2 or Tr1 Cytokine Profiles

1999 • 33 citations

Control of virus-induced lymphoproliferation: Epstein-Barr virus-induced lymphoproliferation and host immunity

1997 • 27 citations

Ultraviolet Light and Interleukin-10 Modulate Expression of Cytokines by Transformed Human Dermal Microvascular Endothelial Cells (HMEC-1)

1998 • 23 citations

Cell-Type-Dependent Induction of eotaxin and CCR3 by Ionizing Radiation

2000 • 22 citations

Immunotherapy for Lung Metastases of Murine Renal Cell Carcinoma

1999 • 22 citations

The influence of therapeutic irradiation of blood and peripheral lymph lymphocytes.

1978 • 18 citations

T cells are responsive to the simian virus 40 large tumor antigen transgenically expressed in pancreatic islets.

1993 • 15 citations