Focal Radiation Therapy Combined with 4-1BB Activation and CTLA-4 Blockade Yields Long-Term Survival and a Protective Antigen-Specific Memory Response in a Murine Glioma Model

Radiotherapy plus Concomitant and Adjuvant Temozolomide for Glioblastoma

2005 • 18,835 citations

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

2010 • 14,016 citations

The blockade of immune checkpoints in cancer immunotherapy

2012 • 12,062 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

2009 • 7,014 citations

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

2011 • 4,304 citations

Nivolumab plus Ipilimumab in Advanced Melanoma

2013 • 4,054 citations

Enhancement of Antitumor Immunity by CTLA-4 Blockade

1996 • 3,585 citations

Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial

2012 • 1,052 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Systemic effects of local radiotherapy

2009 • 906 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

Anti-PD-1 Blockade and Stereotactic Radiation Produce Long-Term Survival in Mice With Intracranial Gliomas

2013 • 834 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Immunostimulatory monoclonal antibodies for cancer therapy

2007 • 596 citations

Immunosuppression in Patients with High-Grade Gliomas Treated with Radiation and Temozolomide

2011 • 492 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

Combining radiotherapy and immunotherapy: A revived partnership

2005 • 349 citations

High-Resolution, Small Animal Radiation Research Platform With X-Ray Tomographic Guidance Capabilities

2008 • 340 citations

Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4+ T Cell Compartment without Affecting Regulatory T-Cell Function

2007 • 320 citations

Ipilimumab and radiation therapy for melanoma brain metastases

2013 • 273 citations

Anti–CTLA-4 Antibody Therapy: Immune Monitoring During Clinical Development of a Novel Immunotherapy

2010 • 237 citations

Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production

2011 • 201 citations

Combination Therapy with Anti–CTL Antigen-4 and Anti-4-1BB Antibodies Enhances Cancer Immunity and Reduces Autoimmunity

2006 • 168 citations

Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas.

1997 • 154 citations

Challenges in Immunotherapy Presented by the Glioblastoma Multiforme Microenvironment

2011 • 134 citations

Sequential Immunotherapy by Vaccination With GM-CSF–expressing Glioma Cells and CTLA-4 Blockade Effectively Treats Established Murine Intracranial Tumors

2012 • 119 citations

Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model.

2003 • 118 citations

Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges.

2008 • 108 citations

Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer

2013 • 78 citations

Mechanisms of Local Immunoresistance in Glioma

2009 • 74 citations

Combining radiation and immunotherapy for synergistic antitumor therapy.

2009 • 55 citations

Combination Immunotherapy with 4-1BBL and CTLA-4 Blockade for the Treatment of Prostate Cancer

2012 • 36 citations

CT Guidance is Needed to Achieve Reproducible Positioning of the Mouse Head for Repeat Precision Cranial Irradiation

2009 • 29 citations

Deleted Work

1955 • 0 citations