Immune privilege or privileged immunity?

Innate Immune Recognition

2002 • 8,157 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

1995 • 2,028 citations

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

2007 • 1,378 citations

Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye.

1948 • 1,042 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

History, Heterogeneity, Developmental Biology, and Functions of Quiescent Hepatic Stellate Cells

2001 • 716 citations

What is immune privilege (not)?

2006 • 708 citations

T<scp>he</scp> P<scp>athogenesis of</scp> O<scp>ral</scp> L<scp>ichen</scp> P<scp>lanus</scp>

2002 • 700 citations

Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view

1992 • 653 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Friendly and dangerous signals: is the tissue in control?

2006 • 525 citations

What is the blood–brain barrier (not)?

2006 • 497 citations

Migratory Activity and Functional Changes of Green Fluorescent Effector Cells before and during Experimental Autoimmune Encephalomyelitis

2001 • 438 citations

See no evil, hear no evil, do no evil: the lessons of immune privilege

2006 • 418 citations

The testis in immune privilege

2006 • 416 citations

Indoleamine 2,3‐dioxygenase in T‐cell tolerance and tumoral immune escape

2008 • 391 citations

The origin and cell lineage of microglia—New concepts

2007 • 382 citations

An Innate Sense of Danger

2002 • 355 citations

The human hair follicle immune system: cellular composition and immune privilege

2000 • 341 citations

Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation

2003 • 334 citations

Creating immune privilege: active local suppression that benefits friends, but protects foes

2007 • 328 citations

The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphoma

2007 • 319 citations

Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations

1999 • 313 citations

Specific Recruitment of CC Chemokine Receptor 4–Positive Regulatory T Cells in Hodgkin Lymphoma Fosters Immune Privilege

2006 • 295 citations

Spontaneous autoimmunity prevented by thymic expression of a single self-antigen

2006 • 271 citations

Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack

2007 • 257 citations

Collapse and Restoration of MHC Class-I-Dependent Immune Privilege

2004 • 256 citations

Studies on the induction of anterior chamber‐associated immune deviation (ACAID) III. Induction of ACAID depends upon intraocular transforming growth factor‐β

1992 • 250 citations

A monoclonal antibody specific for mouse dendritic cells.

1982 • 249 citations

The Hair Follicle and Immune Privilege

2003 • 244 citations

The tumor‐draining lymph node as an immune‐privileged site

2006 • 231 citations

Cellular and molecular mechanisms of liver tolerance

2006 • 227 citations

TGF‐β: a mobile purveyor of immune privilege

2006 • 227 citations

The Immunology of Pregnancy

1999 • 210 citations

Thymic expression of autoantigens correlates with resistance to autoimmune disease.

1997 • 193 citations

TRAIL (Apo-2L) and TRAIL Receptors in Human Placentas: Implications for Immune Privilege

1999 • 191 citations

Studies on the induction of anterior chamber-associated immune deviation (ACAID). 1. Evidence that an antigen-specific, ACAID-inducing, cell-associated signal exists in the peripheral blood.

1991 • 179 citations

Effects of Liver-Derived Dendritic Cell Progenitors on Th1- and Th2-Like Cytokine Responses In Vitro and In Vivo

2000 • 178 citations

A vision of cell death: insights into immune privilege

1997 • 177 citations

IMMUNE PRIVILEGE IN THE TESTIS

1983 • 177 citations

Infectious tolerance and the long‐term acceptance of transplanted tissue

2006 • 168 citations

Turnover of resident retinal microglia in the normal adult mouse

2007 • 155 citations

Ocular autoimmunity: the price of privilege?

2006 • 151 citations

Stranger in a strange land

2006 • 149 citations

Leukocyte Trafficking in Experimental Autoimmune Uveitis: Breakdown of Blood–Retinal Barrier and Upregulation of Cellular Adhesion Molecules

2003 • 146 citations

IMMUNE PRIVILEGE IN THE TESTIS

1985 • 141 citations

Myeloid dendritic cell precursors generated from bone marrow suppress T cell responses via cell contact and nitric oxide production in vitro

2005 • 141 citations

Immune privilege induced by regulatory T cells in transplantation tolerance

2006 • 135 citations

The role of HLA-G in human pregnancy

2006 • 132 citations

Immune Privilege in Hair Growth

1991 • 131 citations

Immune privilege in sites of chronic infection: Leishmania and regulatory T cells

2006 • 130 citations

Monoclonal Antibody-Mediated CD200 Receptor Signaling Suppresses Macrophage Activation and Tissue Damage in Experimental Autoimmune Uveoretinitis

2007 • 126 citations

LYVE-1–Positive Macrophages Are Present in Normal Murine Eyes

2007 • 124 citations

A vision of cell death: Fas ligand and immune privilege 10 years later

2006 • 119 citations

Cellular and molecular events during early thymus development

2006 • 117 citations

Anatomy and Immunology of the Ocular Surface

2007 • 115 citations

Induction of tolerance using Fas ligand: a double-edged immunomodulator

2004 • 113 citations

γδ T Cells Are Needed for Ocular Immune Privilege and Corneal Graft Survival

2001 • 109 citations

Mouse Models of Experimental Autoimmune Uveitis

2008 • 106 citations

Inhibition of Inflammatory Lymphangiogenesis by Integrin α5 Blockade

2007 • 105 citations

CD34 ⁺ Corneal Stromal Cells Are Bone Marrow–Derived and Express Hemopoietic Stem Cell Markers

2005 • 103 citations

Immune privilege in the gut: the establishment and maintenance of non‐responsiveness to dietary antigens and commensal flora

2006 • 100 citations

CELL DEATH AND IMMUNE PRIVILEGE

2002 • 97 citations

A historical perspective on immunological privilege

2006 • 96 citations

Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface.

2003 • 96 citations

AIRE's CARD Revealed, a New Structure for Central Tolerance Provokes Transcriptional Plasticity

2007 • 95 citations

Holey barrier

2003 • 94 citations

Immunohistochemical Analysis of Regulatory T Cell Markers FOXP3 and GITR on CD4⁺CD25⁺ T Cells in Normal Skin and Inflammatory Dermatoses

2007 • 93 citations

Identification of Novel Dendritic Cell Populations in Normal Mouse Retina

2007 • 92 citations

Induction of Regulatory T Cells and Dominant Tolerance by Dendritic Cells Incapable of Full Activation

2007 • 91 citations

Dendritic cells and macrophages in the uveal tract of the normal mouse eye

1999 • 89 citations

Immune privilege and suppression of immunogenic inflammation in the anterior chamber of the eye

1991 • 86 citations

Membrane Fas Ligand Activates Innate Immunity and Terminates Ocular Immune Privilege

2002 • 81 citations

Critical but divergent roles for CD62L and CD44 in directing blood monocyte trafficking in vivo during inflammation

2008 • 80 citations

Class II major histocompatibility complex (Ia) antigen-bearing dendritic cells within the iris and ciliary body of the rat eye: distribution, phenotype and relation to retinal microglia.

1992 • 78 citations

CD4 T Cell-Dependent Autoimmunity against a Melanocyte Neoantigen Induces Spontaneous Vitiligo and Depends upon Fas-Fas Ligand Interactions

2006 • 77 citations

Systemic Immune Deviation in the Brain That Does Not Depend on the Integrity of the Blood-Brain Barrier

2000 • 76 citations

HLA-G truncated isoforms can substitute for HLA-G1 in fetal survival

2000 • 74 citations

The Induction of Anterior Chamber-Associated Immune Deviation

2007 • 70 citations

Using Tolerance Induced Via the Anterior Chamber of the Eye to Inhibit Th2-Dependent Pulmonary Pathology

2002 • 66 citations

The Role of Fas Ligand and TNF-Related Apoptosis-Inducing Ligand (TRAIL) in the Ocular Immune Response

2007 • 64 citations

A Key Role for TGF-β Signaling to T Cells in the Long-Term Acceptance of Allografts

2007 • 64 citations

Differentiation to the CCR2+ Inflammatory Phenotype In Vivo Is a Constitutive, Time-Limited Property of Blood Monocytes and Is Independent of Local Inflammatory Mediators

2005 • 63 citations

Immunological Tolerance

1961 • 63 citations

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels

2003 • 62 citations

Immune privilege and HIV‐1 persistence in the CNS

2006 • 61 citations

RECONSIDERATION OF THE LYMPHATIC DRAINAGE OF THE RAT TESTIS

1983 • 58 citations

Intratumoral CRH modulates immuno-escape of ovarian cancer cells through FasL regulation

2007 • 57 citations

Limited Peripheral T Cell Anergy Predisposes to Retinal Autoimmunity

2007 • 57 citations

THE IMMUNE RESPONSE TO CORNEAL ALLOGRAFT REQUIRES A SITE-SPECIFIC DRAINING LYMPH NODE1

2002 • 55 citations

Human decidual natural killer cells as a source and target of macrophage migration inhibitory factor

2005 • 46 citations

Fate of orthotopic corneal allografts in C57BL/6 mice

1998 • 44 citations

Primer: mechanisms of immunologic tolerance

2006 • 44 citations

Death receptor expression and function at the human blood brain barrier

2007 • 41 citations

Intermediate and Posterior Uveitis

2007 • 39 citations

Role of splenic B cells in the immune privilege of the anterior chamber of the eye

1995 • 38 citations

Considering Fas ligand as a target for therapy

2005 • 37 citations

HLA-G expression: immune privilege for tumour cells?

1999 • 37 citations

How Herpes Simplex Virus Type 1 Rescinds Corneal Privilege

2007 • 36 citations

Fas-Fas ligand-mediated apoptosis within aqueous during idiopathic acute anterior uveitis.

1999 • 33 citations

Lymph node removal enhances corneal graft survival in mice at high risk of rejection

2004 • 32 citations

Intranasal immunization with C. muridarum major outer membrane protein (MOMP) and cholera toxin elicits local production of neutralising IgA in the prostate

2004 • 32 citations

Immune Privilege of the Eye and Fetus: Parallel Universes?

2005 • 30 citations

Ocular Immune Privilege and CD1d-Reactive Natural Killer T Cells

2002 • 30 citations

Therapies Based on Principles of Ocular Immune Privilege

2007 • 25 citations

Apoptotic depletion of infiltrating mucosal lymphocytes associated with Fas ligand expression by Helicobacter pylori-infected gastric mucosal epithelium: human glandular stomach as a site of immune privilege.

2000 • 25 citations

Nitric Oxide and Indoleamine 2,3-Dioxygenase Mediate CTLA4Ig-Induced Survival in Heart Allografts in Rats

2007 • 22 citations

In situ suppression of delayed-type hypersensitivity: another mechanism for sustaining the immune privilege of the anterior chamber.

1991 • 20 citations

Dendritic Cells and “Dendritic” Macrophages in the Uveal Tract

1993 • 15 citations

Requirement for splenic CD4+ T cells in the immune privilege of the anterior chamber of the eye

1999 • 15 citations

Cross Talk among Cells Promoting Anterior Chamber-Associated Immune Deviation

2007 • 14 citations

Transcriptional regulation in thymic epithelial cells for the establishment of self tolerance

2007 • 13 citations

Th2 Differentiation in Distinct Lymph Nodes Influences the Site of Mucosal Th2 Immune-Inflammatory Responses

2007 • 13 citations

A Novel Treatment for Ocular Tumors Using Membrane FasL Vesicles to Activate Innate Immunity and Terminate Immune Privilege

2005 • 12 citations

Role of Fas Ligand in Conferring Immune Privilege to Non‐Lymphoid Cells

1997 • 10 citations

Transcriptional Control of Thymocyte Positive Selection

2004 • 8 citations

Lymphocyte subsets in conjunctival mucosa-associated-lymphoid-tissue after exposure to retinal-S-antigen.

1998 • 8 citations

Self/nonself discrimination among immunoregulatory (CD4) T cells

2000 • 7 citations

Immunopathology of the eye

2008 • 2 citations

Immunopathology of the eye

2008 • 2 citations