The Confluence of Stereotactic Ablative Radiotherapy and Tumor Immunology

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Cancer immunoediting: from immunosurveillance to tumor escape

2002 • 4,911 citations

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 • 2,814 citations

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

2003 • 1,538 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti–CTLA-4 Antibody

2009 • 1,480 citations

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

2009 • 1,232 citations

Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

2005 • 1,000 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

2005 • 894 citations

Universal Survival Curve and Single Fraction Equivalent Dose: Useful Tools in Understanding Potency of Ablative Radiotherapy

2008 • 613 citations

The Linear-Quadratic Model Is an Appropriate Methodology for Determining Isoeffective Doses at Large Doses Per Fraction

2008 • 496 citations

The Linear-Quadratic Model Is Inappropriate to Model High Dose per Fraction Effects in Radiosurgery

2008 • 467 citations

External Beam Radiation of Tumors Alters Phenotype of Tumor Cells to Render Them Susceptible to Vaccine-Mediated T-Cell Killing

2004 • 425 citations

Radiation Enhances Regulatory T Cell Representation

2010 • 368 citations

Radiation to Stromal Fibroblasts Increases Invasiveness of Pancreatic Cancer Cells through Tumor-Stromal Interactions

2004 • 353 citations

High-Resolution, Small Animal Radiation Research Platform With X-Ray Tomographic Guidance Capabilities

2008 • 340 citations

Extending the linear–quadratic model for large fraction doses pertinent to stereotactic radiotherapy

2004 • 325 citations

A Sense of Danger from Radiation¹

2004 • 317 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

Effect of Host Immune Capability on Radiocurability and Subsequent Transplantability of a Murine Fibrosarcoma<xref ref-type="fn" rid="FN2">2</xref>

1979 • 236 citations

Immune Modulation by Ionizing Radiation and its Implications for Cancer Immunotherapy

2002 • 200 citations

A Generalized Linear-Quadratic Model for Radiosurgery, Stereotactic Body Radiation Therapy, and High–Dose Rate Brachytherapy

2010 • 172 citations

Radiation-induced normal tissue injury: Role of adhesion molecules in leukocyte-endothelial cell interactions

1999 • 166 citations

T-Cell Responses to Survivin in Cancer Patients Undergoing Radiation Therapy

2008 • 140 citations

Combination of ?-irradiation and dendritic cell administration induces a potent antitumor response in tumor-bearing mice: Approach to treatment of advanced stage cancer

2001 • 131 citations

Radiotherapy Decreases Vascular Density and Causes Hypoxia with Macrophage Aggregation in TRAMP-C1 Prostate Tumors

2009 • 121 citations

Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naïve T-cell priming

2005 • 119 citations

Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

2010 • 119 citations

Combination of External Beam Radiotherapy (EBRT) With Intratumoral Injection of Dendritic Cells as Neo-Adjuvant Treatment of High-Risk Soft Tissue Sarcoma Patients

2011 • 114 citations

Radiation-induced, immunologically mediated regression of an established tumor as an example of successful therapeutic immunomanipulation. Preferential elimination of suppressor T cells allows sustained production of effector T cells.

1986 • 102 citations

Radiation enhances tumor necrosis factor α production by murine brain cells

1991 • 100 citations

Severe Impairment in Early Host Defense Against Listeria monocytogenes in Mice Deficient in Acid Sphingomyelinase

2003 • 88 citations

In vivo tracking of tumor-specific T cells

2001 • 59 citations

Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation

2003 • 56 citations

Intrinsic and Extrinsic Characteristics of Human Tumors Relevant to Radiosurgery: Comparative Cellular Radiosensitivity and Hypoxic Percentages

1994 • 49 citations

Immunosuppression in irradiated breast cancer patients: in vitro effect of cyclooxygenase inhibitors.

1989 • 48 citations

Bedside to bench and back again: how animal models are guiding the development of new immunotherapies for cancer

2004 • 47 citations

High Dose–Per-Fraction Irradiation of Limited Lung Volumes Using an Image-Guided, Highly Focused Irradiator: Simulating Stereotactic Body Radiotherapy Regimens in a Small-Animal Model

2010 • 45 citations

Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: Experimental models and clinical perspectives

2009 • 36 citations

Assumptions of the tumor ‘escape’ hypothesis

2002 • 33 citations

Tumor‐specific T helper activity can be abrogated by two distinct suppressor cell mechanisms

1982 • 33 citations

Stereotactic body radiation therapy (stereotactic ablative radiotherapy) for stage I non-small cell lung cancer--updates of radiobiology, techniques, and clinical outcomes.

2010 • 24 citations

Radiosurgical Pathology of Brain Tumors: Metastases, Schwannomas, Meningiomas, Astrocytomas, Hemangioblastomas

2007 • 23 citations

The Florida Melanoma Trial I: A Prospective Multicenter Phase I/II Trial of Postoperative Hypofractionated Adjuvant Radiotherapy with Concurrent Interferon-Alfa-2b in the Treatment of Advanced Stage III Melanoma with Long-Term Toxicity Follow-Up

2012 • 19 citations

Local irradiation of murine melanoma affects the development of tumour‐specific immunity

2009 • 16 citations