TGFβ Inhibition Prior to Hypofractionated Radiation Enhances Efficacy in Preclinical Models

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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The blockade of immune checkpoints in cancer immunotherapy

2012 • 12,062 citations

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

2012 • 11,574 citations

Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

2006 • 5,923 citations

Nivolumab plus Ipilimumab in Advanced Melanoma

2013 • 4,054 citations

Coordinated regulation of myeloid cells by tumours

2012 • 3,227 citations

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

2009 • 2,751 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma

2012 • 1,925 citations

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

2011 • 1,618 citations

Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 • 1,499 citations

Targeting the TGFβ signalling pathway in disease

2012 • 1,297 citations

Cancer despite immunosurveillance: immunoselection and immunosubversion

2006 • 1,263 citations

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

2009 • 1,232 citations

Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.

1992 • 1,217 citations

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 • 1,173 citations

Immune-Mediated Inhibition of Metastases after Treatment with Local Radiation and CTLA-4 Blockade in a Mouse Model of Breast Cancer

2005 • 940 citations

Enhanced expression of transforming growth factor β isoforms in pancreatic cancer correlates with decreased survival

1993 • 518 citations

CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer

2013 • 517 citations

American Association for Cancer Research

2000 • 479 citations

TGFβ signaling plays a critical role in promoting alternative macrophage activation

2012 • 360 citations

Induced sensitization of tumor stroma leads to eradication of established cancer by T cells

2007 • 353 citations

Workshop R: Tumor Immunology, Abstract R1 bis R30

2001 • 312 citations

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

2012 • 298 citations

Phase 1 Study of Stereotactic Body Radiotherapy and Interleukin-2—Tumor and Immunological Responses

2012 • 298 citations

High levels of transforming growth factor beta 1 in patients with colorectal cancer: Association with disease progression

1996 • 285 citations

Tumor-Associated Transforming Growth Factor-β and Interleukin-10 Contribute to a Systemic Th2 Immune Phenotype in Pancreatic Carcinoma Patients

1999 • 227 citations

TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer CellsIn Vitroand Promotes Tumor Control by RadiationIn Vivo

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TGF-β1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors

2000 • 159 citations

Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice

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Changes in plasma TGFβ levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis

1994 • 147 citations

LY2109761 Attenuates Radiation-Induced Pulmonary Murine Fibrosis via Reversal of TGF-β and BMP-Associated Proinflammatory and Proangiogenic Signals

2012 • 134 citations

Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation

2009 • 120 citations

Abscopal Regression of Antigen Disparate Tumors by Antigen Cascade After Systemic Tumor Vaccination in Combination with Local Tumor Radiation

2012 • 112 citations

A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection

2007 • 110 citations

Expression of NF-κB p50 in Tumor Stroma Limits the Control of Tumors by Radiation Therapy

2012 • 92 citations

Combining Physical and Biologic Parameters to Predict Radiation-Induced Lung Toxicity in Patients With Non-Small-Cell Lung Cancer Treated With Definitive Radiation Therapy

2012 • 89 citations

Novel zinc-based fixative for high quality DNA, RNA and protein analysis

2007 • 89 citations

Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

2013 • 80 citations

Phase I/II study of GC1008: A human anti-transforming growth factor-beta (TGFβ) monoclonal antibody (MAb) in patients with advanced malignant melanoma (MM) or renal cell carcinoma (RCC)

2008 • 79 citations

SM16, an Orally Active TGF-β Type I Receptor Inhibitor Prevents Myofibroblast Induction and Vascular Fibrosis in the Rat Carotid Injury Model

2008 • 78 citations

The small molecule TGF-β signaling inhibitor SM16 synergizes with agonistic OX40 antibody to suppress established mammary tumors and reduce spontaneous metastasis

2011 • 64 citations

The Impact of the Myeloid Response to Radiation Therapy

2013 • 49 citations

The Peripheral Myeloid Expansion Driven by Murine Cancer Progression Is Reversed by Radiation Therapy of the Tumor

2013 • 42 citations

An orally active small molecule TGF-beta receptor I antagonist inhibits the growth of metastatic murine breast cancer.

2009 • 40 citations

Inhibition of Transforming Growth Factor-β, Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor Reduced Late Rectal Injury Induced by Irradiation

2009 • 28 citations

Intrinsic resistance to anticancer agents in the murine pancreatic adenocarcinoma PANC02

1992 • 26 citations

Variations of circulating endothelial progenitor cells and transforming growth factor-beta-1 (TGF-β1) during thoracic radiotherapy are predictive for radiation pneumonitis

2013 • 18 citations

Deleted Work

1955 • 0 citations