The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

The neighbor-joining method: a new method for reconstructing phylogenetic trees.

1987 • 59,130 citations

P450 GENES: STRUCTURE, EVOLUTION, AND REGULATION

1987 • 1,559 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

The cytochrome P-450 system in fish, aquatic toxicology and environmental monitoring

1992 • 626 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Evolution of the P450 gene superfamily:

1990 • 508 citations

Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver

1989 • 480 citations

The effect of selective serotonin re‐uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes.

1992 • 456 citations

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

1989 • 440 citations

Cloning and Sequence of the Human Gene for P450cl7 (Steroid 17α-Hydroxylase/17,20 Lyase): Similarity with the Gene for P450c21

1987 • 415 citations

The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene.

1989 • 407 citations

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes

1990 • 387 citations

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

1989 • 382 citations

Characterization of Two Genes Encoding Human Steroid 11β-Hydroxylase (P-45011β)

1989 • 377 citations

Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis.

1990 • 365 citations

Human cytochromes P450: problems and prospects

1992 • 364 citations

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

1991 • 326 citations

Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis

1989 • 323 citations

Metabolic activation of carcinogens

1992 • 271 citations

Regulation of the cytochrome P450 enzyme system in fish

1992 • 265 citations

Cytochromes P-450 in rats: structures, functions, properties and relevant human forms

1992 • 245 citations

Coding Nucleotide, 5′ Regulatory, and Deduced Amino Acid Sequences of P-450BM-3, a Single Peptide Cytochrome P-450:NADPH-P-450 Reductase from Bacillus megaterium

1989 • 242 citations

17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1A1: A comparison of the activities induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 cells with those from heterologous expression of the cDNA

1992 • 242 citations

Role of genetics and drug metabolism in human cancer risk

1991 • 236 citations

Trout P450IA1: cDNA and Deduced Protein Sequence, Expression in Liver, and Evolutionary Significance

1988 • 211 citations

Regulation of cholesterol 7 alpha-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7 alpha-hydroxylase mRNA.

1990 • 208 citations

Expression of CYP2D6 in developing human liver

1991 • 208 citations

Cyclic AMP-dependent and -independent Regulation of Cholesterol Side Chain Cleavage Cytochrome P-450 (P-450scc) in Rat Ovarian Granulosa Cells and Corpora Lutea.

1989 • 197 citations

Biotransformation of lovastatin

1991 • 195 citations

Identification of the human liver cytochrome P-450 responsible for coumarin 7-hydroxylase activity

1990 • 193 citations

Evolution of cytochrome P-450 proteins.

1987 • 190 citations

Isolation of two developmentally regulated genes involved in spore wall maturation in Saccharomyces cerevisiae.

1990 • 190 citations

Species differences and interindividual variation in liver microsomal cytochrome P450 2A enzymes: Effects on coumarin, dicumarol, and testosterone oxidation

1992 • 187 citations

Inhibitors of imipramine metabolism by human liver microsomes.

1992 • 165 citations

Sex-specific cytochrome P450 as a cause of sex-and species-related differences in drug toxicity

1992 • 163 citations

Rat P450_17αfrom Testis: Characterization of a Full-Length cDNA Encoding a Unique Steroid Hydroxylase Capable of Catalyzing Both Δ⁴- and Δ⁵-Steroid-17,20-Lyase Reactions

1989 • 160 citations

cDNA cloning and sequence and cDNA-directed expression of human P450 IIB1: identification of a normal and two variant cDNAs derived from the CYP2B locus on chromosome 19 and differential expression of the IIB mRNAs in human liver

1989 • 159 citations

The expression of a functional cDNA encoding the chicken cytochrome P-450arom (aromatase) that catalyzes the formation of estrogen from androgen.

1988 • 158 citations

The Toxicokinetics of PCBs in Marine Mammals with Special Reference to Possible Interactions of Individual Congeners with the Cytochrome P450-dependent Monooxygenase System: an Overview

1992 • 158 citations

Human cytochrome P-450 enzymes

1992 • 157 citations

Isolation and sequence of cDNA encoding a cytochrome P-450 from an insecticide-resistant strain of the house fly, Musca domestica.

1989 • 155 citations

Degradation of cytochrome P450 2E1: Selective loss after labilization of the enzyme

1992 • 151 citations

cDNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment

1991 • 143 citations

Structural characterization of the human estrogen synthetase (aromatase) gene

1990 • 143 citations

HumanCYP1A2: Sequence, Gene Structure, Comparison with the Mouse and Rat Orthologous Gene, and Differences in Liver1A2mRNA Expression

1989 • 141 citations

The Rat Clofibrate-InducibleCYP4ASubfamily II. cDNA Sequence of IVA3, Mapping of theCyp4aLocus to Mouse Chromosome 4, and Coordinate and Tissue-Specific Regulation of theCYP4AGenes

1989 • 140 citations

Sequence analysis of ripening-related cytochrome P-450 cDNAs from avocado fruit.

1990 • 139 citations

Olfactory-specific Cytochrome P-450

1989 • 130 citations

Molecular cloning of cDNA for vitamin D₃ 25‐hydroxylase from rat liver mitochondria

1990 • 125 citations

The Rat Clofibrate-InducibleCYP4AGene Subfamily I. Complete Intron and Exon Sequence of theCYP4A1andCYP4A2Genes, Unique Exon Organization, and Identification of a Conserved 19-bp Upstream Element

1989 • 122 citations

Zonation of cytochrome P450 isozyme expression and induction in rat liver

1992 • 120 citations

Identification of a new P450 expressed in human lung: complete cDNA sequence, cDNA-directed expression, and chromosome mapping

1989 • 120 citations

A cDNA Encoding a Rat Mitochondrial Cytochrome P450 Catalyzing Both the 26-Hydroxylation of Cholesterol and 25-Hydroxylation of Vitamin D₃: Gonadotropic Regulation of the Cognate mRNA in Ovaries

1990 • 119 citations

Interspecies variations in caffeine metabolism related to cytochrome P4501A enzymes

1992 • 119 citations

Molecular Cloning and Sequence Analysis of cDNA Containing the Entire Coding Region for Human Fetal Liver Cytochrome P-4501

1989 • 118 citations

Fatty acid monooxygenation by P450BM-3: Product identification and proposed mechanisms for the sequential hydroxylation reactions

1992 • 116 citations

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α‐hydroxylase

1990 • 114 citations

Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus

1990 • 109 citations

Characterization of the promoter/regulatory region of the bovine CYP11A (P-450scc) gene. Basal and cAMP-dependent expression.

1990 • 107 citations

Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase

1988 • 106 citations

Cloning of the human cholesterol 7α-hydroxylase gene (CYP7) and localization to chromosome 8q11–q12

1992 • 106 citations

Nucleotide sequence of cytochrome P450 LIAI (lanosterol 14α-demethylase) fromCandida albicans

1989 • 106 citations

Molecular cloning of cDNA for cholesterol 7α‐hydroxylase from rat liver microsomes

1989 • 105 citations

The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats

1989 • 99 citations

The human CYP2F gene subfamily: identification of a cDNA encoding a new cytochrome P450, cDNA-directed expression, and chromosome mapping

1990 • 98 citations

Metabolic Defenses against Plant Allelochemicals

1992 • 97 citations

Molecular cloning and expression of cDNAs encoding rat aldosterone synthase : variants of cytochrome P-450[11β]

1992 • 95 citations

P450 and Human Cancer

1991 • 94 citations

Molecular cloning of a cDNA encoding aldosterone synthase cytochrome P‐450 in rat adrenal cortex

1990 • 93 citations

Expression of P4501A1 in a primary culture of rainbow trout hepatocytes exposed to β-naphthoflavone or 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 • 93 citations

Characterization of the alkane-inducible cytochrome P450 (P450alk) gene from the yeast Candida tropicalis: identification of a new P450 gene family

1989 • 91 citations

cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells.

1989 • 90 citations

The human cytochrome Cyp1A2 gene contains regulatory elements responsive to 3-methylcholanthrene.

1989 • 90 citations

Localization of CYP1A1 and CYP1A2 messenger RNA in normal human liver and in hepatocellular carcinoma byin situ hybridization

1991 • 88 citations

Optimization of yeast‐expressed human liver cytochrome P450 3A4 catalytic activities by coexpressing NADPH‐cytochrome P450 reductase and cytochrome b₅

1992 • 88 citations

Molecular cloning and sequence analysis of cDNA encoding rat adrenal cytochrome P‐450_11β

1989 • 87 citations

Nucleotide sequence and analysis of the plant-inducible locus pinF from Agrobacterium tumefaciens

1989 • 85 citations

The structure of cDNA clones encoding the aromatase P-450 isolated from a rat Leydig cell tumor line demonstrates differential processing of aromatase mRNA in rat ovary and a neoplastic cell line

1990 • 85 citations

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

1989 • 81 citations

Identification of a novel P450 expressed in rat lung: cDNA cloning and sequence, chromosome mapping, and induction by 3-methylcholanthrene

1989 • 79 citations

Acetone‐regulated synthesis and degradation of cytochrome P4502E2 and cytochrome P4502B1 in rat liver

1991 • 79 citations

The Structure and Characterization of Type I P-45015α Gene as Major Steroid 15α-Hydroxylase and Its Comparison with Type II P-45015α Gene

1989 • 77 citations

Endogenously-mediated, pretranslational suppression of cytochrome P4501A in PCB-contaminated flounder

1992 • 76 citations

Effects of indole-3-carbinol on biotransformation enzymes in the rat: in vivo changes in liver and small intestinal mucosa in comparison with primary hepatocyte cultures

1992 • 75 citations

Molecular cloning of monkey liver cytochrome P-450 cDNAs

1992 • 74 citations

Isolation and characterization of a cytochrome P450 of the IIA subfamily from human liver microsomes

1991 • 74 citations

Rat testis P-45017α cDNA: The deduced amino acid sequence, expression and secondary structural configuration

1988 • 73 citations

The rat P450 IID subfamily: Complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site

1990 • 71 citations

Isolation and molecular characterisation of the benzoate-para-hydroxylase gene (bphA) of Aspergillus niger: A member of a new gene family of the cytochrome P450 superfamily

1990 • 70 citations

Expression of functional bovine cholesterol side chain cleavage cytochrome P450 (P450scc) in Escherichia coli

1991 • 68 citations

Primary structures of cytochrome P-450 isozyme 5 from rabbit and rat and regulation of species-dependent expression and induction in lung and liver: identification of cytochrome P-450 gene subfamily IVB.

1989 • 67 citations

Cloning and expression of three rabbit kidney cDNAs encoding lauric acid .omega.-hydroxylases

1990 • 66 citations

Cloning and characterization of a novel CYP3A1 allelic variant: Analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone

1992 • 65 citations

Isolation of a new human fetal liver cytochrome P450 cDNA clone: Evidence for expression of a limited number of forms of cytochrome P450 in human fetal livers

1989 • 64 citations

An operon containing the genes for cholesterol oxidase and a cytochrome P-450-like protein from a Streptomyces sp

1990 • 64 citations

Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: Characterization of the proteolytic system

1992 • 63 citations

Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescencein situ hybridization

1992 • 63 citations

Human P450scc gene transcription is induced by cyclic AMP and repressed by 12-O-tetradecanoylphorbol-13-acetate and A23187 through independent cis elements.

1990 • 62 citations

The anti-carcinogenic plant compound indole-3-carbinol differentially modulates P450-mediated steroid hydroxylase activities in mice

1992 • 61 citations

In vitro oxidation of oxicam NSAIDs by a human liver cytochrome P450

1992 • 61 citations

Cloning and Characterization of a Novel Member of the Cytochrome P450 Subfamily IVA in Rat Prostate

1990 • 60 citations

Two Forms of ω-Hydroxylase Toward Prostaglandin A and Laurate

1989 • 60 citations

Expression of Two Kinds of Cytochrome P-450(11β) mRNA in Bovine Adrenal Cortex

1988 • 60 citations

Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation

1990 • 58 citations

A novel human cytochrome P4S0 gene (P450IIB): chromosomal localization and evidence for alternative splicing

1988 • 58 citations

Effects of temperature acclimation on the expression of hepatic cytochrome P4501A mRNA and protein in the fish Fundulus heteroclitus

1992 • 57 citations

Molecular modeling of the 3-D structure of cytochrome

1992 • 52 citations

Identification of constitutive and herbicide inducible cytochromes P-450 in Streptomyces griseolus

1988 • 52 citations

Molecular cloning and characterization of the primary structure of the alkane hydroxylating cytochrome P-450 from the yeast Candida maltosa

1989 • 51 citations

Steady-state plasma levels of clomipramine and its metabolites: Impact of the sparteine/debrisoquine oxidation polymorphism

1992 • 51 citations

Effects of cooked brussels sprouts on cytochrome p-450 profile and phase II enzymes in liver and small intestinal mucosa of the rat

1992 • 51 citations

Effects of testosterone and estrogen on hepatic levels of cytochromes P450 2C7 and P450 2C11 in the rat

1992 • 50 citations

Genomic organization of human fetal specific P-450IIIA7(cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5′ flanking region

1992 • 50 citations

cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl

1990 • 49 citations

Sequence of a Chicken Phenobarbital-Inducible Cytochrome P450 cDNA: Regulation of Two P450 mRNAs Transcribed from Different Genes

1989 • 49 citations

Gene family of male-specific testosterone 16α-hydroxylase (C-P-45016α) in mice

1989 • 49 citations

Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology

1992 • 49 citations

Xenobiotic induction of P-450 PB-4 (IIB1) and P-450c (IA1) and associated monooxygenase activities in primary cultures of adult rat hepatocytes

1991 • 48 citations

Species differences in ciprofibrate induction of hepatic cytochrome p450 4A1 and peroxisome proliferation

1992 • 47 citations

Metabolic activation of the pneumotoxin, 3-methylindole, by vaccinia-expressed cytochrome P450s

1991 • 47 citations

Purification of two cytochrome P450 isozymes related to CYP2A and CYP3A gene families from monkey (baboon, Papio papio) liver microsomes

1992 • 45 citations

Effect of dexamethasone and phenobarbital on run-on transcription rate and CYP3A mRNA concentration in rat liver: Changes during development

1992 • 45 citations

Nucleotide sequence of cytochrome P-450 cholesterol side-chain cleavage cDNA isolated from porcine testis

1989 • 45 citations

Localization of cytochrome P-450 gene expression in normal and diseased human liver byin situ hybridization of wax-embedded archival material

1992 • 44 citations

Structural characterization of the bovine CYP17 (17α-hydroxylase) gene

1989 • 44 citations

Relationship between the rate of reductase-cytochrome P450 complex formation and the rate of first electron transfer

1992 • 41 citations

Hormonal regulation of rat renal cytochrome P450s by androgen and the pituitary

1992 • 41 citations

Mapping determinants of the substrate selectivities of P450 enzymes by site-directed mutagenesis

1992 • 41 citations

Absence of CYP3 A Genetic Polymorphism Assessed by Urinary Excretion of 6 β‐Hydroxycortisol in 102 Healthy Subjects on Rifampicin

1992 • 41 citations

Modulation of rat liver peroxisomal and microsomal fatty acid oxidation by starvation

1992 • 40 citations

Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: A case for distinct proteolytic mechanisms?

1992 • 38 citations

Olfactory-specific cytochrome P-450 (P-450olf1; IIG1). Gene structure and developmental regulation.

1990 • 37 citations

Primary structures of multiple forms of cytochrome P-450 isozyme 2 derived from rabbit pulmonary and hepatic cDNAs.

1988 • 37 citations

Molecular cloning, coding nucleotides and the deduced amino acid sequence of P-450BM-1 from Bacillus megaterium

1989 • 35 citations

Complete cDNA sequence of a major 3-methylcholanthrene-inducible cytochrome P-450 isozyme (P-450AFB) of Syrian hamsters with high activity toward aflatoxin B1

1989 • 34 citations

The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter

1989 • 34 citations

cDNA cloning of cytochrome P‐450 related to P‐450_p‐2 from the cDNA library of human placenta

1990 • 33 citations

cDNA and deduced amino acid sequences of human P450 IIA3 (CYP2A3)

1989 • 32 citations

The Structural Genes Encoding P450_sccand P450_aromAre Closely Linked on Mouse Chromosome 9*

1989 • 32 citations

Cytochrome P450 induction and mutagenicity of 2-aminoanthracene (2AA) in rat liver and gut

1992 • 31 citations

Characterization of the rabbit CYP1A1 and CYP1A2 genes: Developmental and dioxin-inducible expression of rabbit liver P4501A1 and P4501A2

1992 • 30 citations

Stable expression of cytochrome P450IIIA7 cDNA in human breast cancer cell line MCF-7 and its application to cytotoxicity testing

1992 • 29 citations

Alternative splicing mechanism in a cytochrome P-450 (P-450PB-1) gene generates the two mRNAs coding for proteins of different functions

1989 • 28 citations

Post-transcriptional regulation of mouse renal cytochrome P450 2E1 by testosterone

1992 • 28 citations

CYP1A1 protein and mRNA in teleosts as an environmental bioindicator: laboratory and environmental studies

1992 • 28 citations

Mapping genes encoding drug-metabolizing enzymes in recombinant inbred mice

1991 • 27 citations

Characterization of a cDNA for rat P-450g, a highly polymorphic, male-specific cytochrome in the P-450IIC subfamily

1989 • 27 citations

Molecular cloning of monkey P450 1A1 cDNA and expression in yeast

1992 • 27 citations

Cloning and Characterization of Bovine Cytochrome P-450(11β) Genes1

1989 • 26 citations

Regulation of expression of the genes encoding steroidogenic enzymes in the ovary

1992 • 26 citations

Characterization of a rabbit gene encoding a clofibrate-inducible fatty acid ω-hydroxylase: CYP4A6

1992 • 26 citations

Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes

1992 • 26 citations

Heterogeneity within the alkane‐inducible cytochrome P450 gene family of the yeast Candida tropicalis

1989 • 26 citations

The effect of age on inducibility of various types of rat liver cytochrome P-450

1992 • 25 citations

Cytochrome P-450 forms and its inducibility by PCB isomers in black-headed gulls and black-tailed gulls

1992 • 25 citations

The cerium-induced liver injury and oxidative frug metabolism in DBA/2 and C57BL/6 mice

1991 • 24 citations

Mutagenic activation of aflatoxin B1 by pulmonary, renal, and hepatic cytochrome P450s from rats

1992 • 24 citations

Structural and Regulatory Analysis of a Cytochrome P450 Gene (CYP2C12) Expressed Predominantly in Female Rat Liver

1990 • 24 citations

P450BM-3: Reduction by NADPH and sodium dithionite

1992 • 23 citations

Topological analysis of the active sites of cytochromes P450IIB4 (rabbit), P450IIB10 (mouse), and P450IIB11 (dog) by in situ rearrangement of phenyl-iron complexes

1992 • 23 citations

Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7

1990 • 23 citations

Reconstitution of cytochrome P4502B4 (LM2) activity with camphor and linalool monooxygenase electron donors

1992 • 23 citations

Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: Role of the nuclear 6 s and 4 s proteins

1992 • 23 citations

Functional expression of mammalian cytochromes P450IIB in the yeast Saccharomyces cerevisiae

1991 • 23 citations

Ontogenic development of liver progesterone metabolism in female sheep. Contribution of cytochrome P4502B and P4503A subfamilies

1992 • 22 citations

Comparison of the effects of nafenopin on hepatic peroxisome proliferation and replicative DNA synthesis in the rat and Syrian hamster

1992 • 22 citations

The contribution of specific cytochromes P-450 in the metabolism of 7,12-dimethylbenz[a]anthracene in rat and human liver microsomal membranes

1991 • 22 citations

Molecular advances for the cytochrome P-450 superfamily

1991 • 22 citations

Purification and characterization of cytochrome P450 2E2 from hepatic microsomes of neonatal rabbits

1991 • 22 citations

Purification and Molecular Characterization of β-Naphthoflavone–Inducible Cytochrome P-450 from Rat Epidermis

1992 • 22 citations

Structure of 5′ Regions and Expression of Phenobarbital-Inducible Rabbit Cytochrome P450IIC Genes

1990 • 22 citations

Efficient electropulse transformation of intact Candida maltosa cells by different homologous vector plusmids

1992 • 21 citations

Effect of mutations at Lys250, Arg251, and Lys253 of cytochrome P450 1A2 on the catalytic activities and the bindings of bifunctional axial ligands

1992 • 21 citations

Differential regulation of cytochrome(s) P450 2B1/2 by phenobarbital in hepatic hyperplastic nodules induced by aflatoxin B1 or diethylnitrosamine plus 2-acetylaminofluorene in male F344 rats

1991 • 20 citations

Structure-activity relationships for induction of peroxisomal enzyme activities in primary rat hepatocyte cultures

1993 • 20 citations

5′ flanking sequence of the gene for rat hepatic cytochrome P450e

1987 • 20 citations

Actinomycete cytochromes P‐450 involved in oxidative metabolism: Biochemistry and molecular biology∗

1992 • 20 citations

Isolation and Characterization of Rat Cytochrome P-450IIB Gene Family Members

1989 • 20 citations

Structural and Regulatory Analysis of the Male-Specific Rat Liver Cytochrome P-450 g: Repression by Continuous Growth Hormone Administration.

1990 • 20 citations

Inhibition of protein synthesis increases the transcription of the phenobarbital-inducible CYP2H1 and CYP2H2 genes in chick embryo hepatocytes

1992 • 20 citations

A cycloheximide-inducible gene ofNeurospora crassabelongs to the cytochrome P-450 superfamily

1989 • 19 citations

Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7

1990 • 18 citations

Combined effect of cadmium and nickel on rat hepatic monooxygenases: possible stimulation of certain cytochrome P-450 isozymes

1992 • 17 citations

Alternative splicing of mRNA encoding rat liver cytochrome P450e (P450IIB2)

1990 • 16 citations

Structure of the rabbit cytochrome P450IIC3 gene, a constitutive member of the P450IIC subfamily

1990 • 16 citations

Induction of hepatic CYP1A in male F344/NCr rats by dietary exposure to Aroclor 1254: Examination of immunochemical, RNA, catalytic, and pharmacokinetic endpoints

1992 • 16 citations

Comparison of cAMP-responsive DNA sequences and their binding proteins associated with expression of the bovine CYP17 and CYP11A and human CYP21B genes

1992 • 16 citations

N‐demethylation of ethylmorphine in pregnant and non‐pregnant women and in men: an evaluation of the effects of sex steroids.

1992 • 15 citations

Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family

1989 • 15 citations

Complete sequence of the rat CYP2A3 gene specifically transcribed in lung

1990 • 15 citations

Cytochrome P450cam-catalyzed oxidation of a hypersensitive radical probe

1992 • 15 citations

Multichannel circular dichroism investigations of the structural stability of bacterial cytochrome P-450

1992 • 14 citations

Characterization of the cytochrome P‐450IID subfamily in bovine liver

1992 • 14 citations

Azidowarfarin photoaffinity probes of purified rat liver cytochrome P4501A1

1992 • 13 citations

Disorders of steroid 11β-hydroxylase isozymes

1992 • 13 citations

Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5.

1990 • 13 citations

Toxicological sifnificance of dog liver cytochrome P-450: examination with the enzyme expressed in Saccharomycees cerevisiae using recombinant expression plasmid

1992 • 12 citations

Isolation of a cytochrome P-450e gene variant and characterization of its 5′ flanking sequences

1987 • 12 citations

Differences in Hepatic Microsomal Cytochrome P‐450 Isoenzyme Induction by Pyrazole, Chronic Ethanol, 3‐Methylcholanthrene, and Phenobarbital in High Alcohol Sensitivity (HAS) and Low Alcohol Sensitivity (LAS) Rats

1992 • 12 citations

The use of polyclonal antibodies raised against rat and trout cytochrome P450 CYP1A1 orthologues to monitor environmental induction in the channel catfish (Ictalurus punctatus)

1992 • 12 citations

Stable expression of monkey cytochrome P-405IA1 cDNA in Chinese hamster CHL cells and its application for detection of mutagenicity of aflatoxin B1

1992 • 12 citations

Hydroxylation of 5α-androstane-3β,17β-diol by rat prostate microsomes: Effects of antibodies and chemical inhibitors of cytochrome P450 enzymes

1992 • 11 citations

Sequence and gene expression of rabbit cytochrome P450 IIC16: comparison to highly related family members

1990 • 11 citations

Comparison of human fetal hepatic and adrenal cytochrome P450 activities with some major gestational steroids and ethylmorphine as substrates

1992 • 11 citations

Promoter elements of the mouse 21-hydroxylase (Cyp-21) gene involved in cell-selective and cAMP-dependent gene expression

1992 • 11 citations

Automated high-performance liquid chromatographic assay for the determination of 7-ethoxycoumarin and umbelliferone

1992 • 10 citations

Tissue-specific expression, induction, and inhibition through metabolic intermediate-complex formation of guinea pig cytochrome P450 belonging to the CYP2B subfamily

1992 • 10 citations

Heterogeneity of rat hepatic Ah Receptor: Identification of two receptor forms which differ in their biochemical properties

1992 • 10 citations

cDNA and deduced amino acid sequences of a male dominant P-450Md mRNA in rats

1990 • 10 citations

Cytochrome P450 lanosterol 14α‐demethylase (ERG11) and manganese superoxide dismutase (SOD1) are adjacent genes in Saccharomyces cerevisiae

1991 • 10 citations

Immunoquantification of cytochrome P‐450 3A on rat paraffin‐embedded liver tissue

1992 • 9 citations

Human and mouse liver coumarin 7‐hydroxylases do not metabolize warfarin in vitro.

1992 • 8 citations

7‐Alkoxyquinoline O‐dealkylation by microsomes from human liver and placenta.

1992 • 8 citations

In vitro metabolism of isaxonine phosphate: formation of two metabolites, 5-hydroxyisaxonine and 2-aminopyrimidine, and covalent binding to microsomal proteins

1992 • 8 citations

Isoelectric focusing of cytochrome P450: Isolation of six phenobarbital-inducible rat liver microsomal isoenzymes

1991 • 8 citations

Two steroid 15α-hydroxylase genes and a homologous gene family in mice

1990 • 8 citations

Characterization of a cDNA for the unexpressed form of cytochrome P-450g from the (-g) rat and differentiation of its mRNA from that of the (+g) phenotype using specific oligoprobes

1990 • 8 citations

Analysis of the duplicated human C4/P450c21/X gene cluster

1992 • 7 citations

Cytochrome P450: cellular distribution and structural considerations

1992 • 7 citations

cDNA cloning and regulation of a novel rat cytochrome P450 of the 2C gene subfamily (P450IIC24)

1991 • 7 citations

Nilutamide inhibits mephenytoin 4-hydroxylation in untreated male rats and in human liver microsomes

1991 • 7 citations

Sequence of a human liver cytochrome P-450 cDNA clone

1990 • 6 citations

Directions to contributors

1990 • 5 citations

Pre-translational induction of pentoxyresorufin O-depentylase by pyridine

1992 • 5 citations

The effect of dilauroyl‐<scp>l</scp>‐3‐phosphatidylcholine on the interaction between cytochrome P‐450 1A1 and benzo[a]pyrene

1992 • 4 citations

Cytochrome P45OCMF cDNA: nucleotide sequence of P45OCMF1b

1989 • 4 citations

Twenty years on: a review of the current practice of drug metabolism and pharmacokinetic studies in the pharmaceutical industry

1992 • 3 citations

Alteration of cytochrome P-450 2C11-dependent testosterone metabolism in Gunn rat liver

1992 • 2 citations

肝臓におけるコレステロール7α‐ヒドロキシラーゼの調節 クローニング,配列とコレステロール7α‐ヒドロキシラーゼmRNAの調節

1990 • 2 citations