The contribution of specific cytochromes P-450 in the metabolism of 7,12-dimethylbenz[a]anthracene in rat and human liver microsomal membranes

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

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1991 • 1,092 citations

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1990 • 496 citations

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1984 • 386 citations

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1986 • 283 citations

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1986 • 258 citations

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1989 • 244 citations

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1986 • 227 citations

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1989 • 221 citations

Interindividual variation among humans in carcinogen metabolism, DNA adduct formation and DNA repair

1989 • 201 citations

Purification and characterization of six cytochrome P-450 isozymes from human liver microsomes

1983 • 192 citations

Characterization, localization and regulation of a novel phenobarbital-inducible form of cytochrome P₄₅₀, compared with three further P₄₅₀-isoenzymes, NADPH P₄₅₀-reductase, glutathione transferases and microsomal epoxide hydrolase

1984 • 152 citations

Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors.

1987 • 152 citations

Identification of a human liver cytochrome P-450 homologous to the major isosafrole-inducible cytochrome P-450 in the rat.

1986 • 110 citations

Human cytochromes P-450

1984 • 99 citations

Sequence of two related P-450 mRNAs transcriptionally increased during rat development. An R.dre.1 sequence occupies the complete 3' untranslated region of a liver mRNA.

1986 • 92 citations

Multiple forms of cytochrome P-450 related to forms induced marginally by phenobarbital. Differences in structure and in the metabolism of alkoxyresorufins

1986 • 90 citations

Cytochrome P-450s: polymorphic multigene families involved in carcinogen activation

1986 • 87 citations

Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.

1988 • 80 citations

Pathways involved in the metabolism and activation of polycyclic hydrocarbons

1986 • 78 citations

Involvement of both syn- and anti-dihydrodiol-epoxides in the binding of 7, 12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures.

1983 • 67 citations

Interindividual variations in the activities of cytosolic and microsomal epoxide hydrolase in human liver

1985 • 62 citations

Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat

1985 • 60 citations

A metabolite of the carcinogen 7,12-dimethylbenz[a]anthracene that reacts predominantly with adenine residues in DNA

1988 • 58 citations

Relative contribution of various forms of cytochrome P450 to the metabolism of benzo[a]pyrene by human liver microsomes

1989 • 56 citations

Isolation of a high spin form of cytochrome P-450 induced in rat liver by 3-methylcholanthrene

1983 • 46 citations

Chromosomal organization of the cytochrome P450-2C gene family in the mouse: a locus associated with constitutive aryl hydrocarbon hydroxylase.

1988 • 45 citations

Isolation and characterization of cDNA clones for cytochromes P-450 immunochemically related to rat hepatic P-450 form PB-1

1986 • 37 citations

Metabolism of 7,12-dimethylbenz(a)anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene by rat liver and microsomes.

1981 • 30 citations

Formation of 7-hydroxymethyl-12-methylbenz(a)anthracene-DNA adducts from 7,12-dimethylbenz(a)anthracene in mouse epidermis.

1983 • 29 citations

Stereoselectivity of microsomal epoxide hydrolase toward diol epoxides and tetrahydroepoxides derived from benz[a]anthracene.

1985 • 29 citations

[19] Purification and assay of liver microsomal epoxide hydrase

1978 • 25 citations

Role of specific cytochrome P-450 isoenzymes in the regio-selective metabolism of 7, 12-dimethylbenz[a]anthracene in microsomes from rats treated with phenobarbital or Sudan III

1988 • 24 citations

Molecular genetics of the human cytochrome P-450 system

1990 • 22 citations

Effects of metyrapone and norharmane on microsomal mono-oxygenase and epoxide hydrolase activities

1984 • 19 citations

The role of secondary metabolism in the metabolic activation of 7,12-dimethylbenz[a]anthracene by rat liver microsomes

1984 • 19 citations

Metabolic activation of 7,12-dimethylbenz[a]anthracene in rat mammary tissue: Fluorescence spectral characteristics of hydrocarbon-DNA adducts

1985 • 15 citations

Selective potent restriction of P450b- but not P450e-dependent 7, 12-dimethylbenz[a]anthracene metabolism by the microsomal environment

1989 • 10 citations

Alterations in the metabolism of 7,12-dimethylbenz[a]anthracene and various xenobiotics by rat hepatic microsomes following Sudan III treatment in vivo

1985 • 9 citations

Metabolic activation of 7,12-dimethylbenz(a)anthracene: role of cytochrome P-450 isoenzymes in the formation of DNA and protein adducts in vitro

1989 • 2 citations

Deleted Work

1955 • 0 citations