Toxicological sifnificance of dog liver cytochrome P-450: examination with the enzyme expressed in Saccharomycees cerevisiae using recombinant expression plasmid

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Experiments in molecular genetics

1972 • 28,260 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: G. H. A. Clowes Memorial Lecture.

1982 • 1,559 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis.

1982 • 520 citations

Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy.

1988 • 465 citations

Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis

1982 • 422 citations

Isolation of yeast histone genes H2A and H2B

1979 • 288 citations

Comparison of in vitro drug metabolism by lung, liver, and kidney of several common laboratory species.

1975 • 260 citations

Sex difference of cytochrome P-450 in the rat: Purification, characterization, and quantitation of constitutive forms of cytochrome P-450 from liver microsomes of male and female rats

1983 • 233 citations

Human Dioxin-Inducible Cytochrome P ₁ -450: Complementary DNA and Amino Acid Sequence

1985 • 233 citations

Expression of Rat Liver Cytochrome P-450MC cDNA inSaccharomyces cerevisiae

1985 • 221 citations

The murine Ah locus. Comparison of the complete cytochrome P1-450 and P3-450 cDNA nucleotide and amino acid sequences.

1984 • 199 citations

Metabolic activation of mutagenic heterocylic aromatic amines from protein pyrolysates

1986 • 187 citations

Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae

1989 • 134 citations

Nucleotide sequence of a full-length cDNA coding for 3-methylcholanthrene-induced rat liver cytochrome P-450MC

1984 • 129 citations

Coding nucleotide sequence of 3-methylcholanthrene-inducible cytochrome P-450d cDNA from rat liver.

1984 • 129 citations

Properties of a Yeast Cytochrome P‐450‐Containing Enzyme System which Catalyzes the Hydroxylation of Fatty Acids, Alkanes, and Drugs

1973 • 116 citations

A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes.

1983 • 109 citations

Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers.

1987 • 108 citations

A comparative study of xenobiotic-metabolizing enzymes in liver and intestine of various animal species.

1974 • 101 citations

[24] Genetic differences in microsomal electron transport: The Ah Locus

1978 • 99 citations

NADPH-cytochrome P-450 reductase of yeast microsomes

1978 • 83 citations

Purification and characterization of the dog hepatic cytochrome P-450 isozyme responsible for the metabolism of 2,2′,4,4′,5,5′-hexachlorobiphenyl

1987 • 83 citations

N-hydroxylation of carcinogenic and mutagenic aromatic amines.

1983 • 81 citations

Cytochrome P-450-mediated activation of pro-carcinogens and promutagens to DNA-damaging products by measuring expression of umu gene in Salmonella typhimurium TA1535/pSK1002

1987 • 71 citations

Analysis of two benzo[a]pyrene-resistant mutants of the mouse hepatoma Hepa-1 P(1)450 gene via cDNA expression in yeast.

1987 • 68 citations

Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily

1989 • 61 citations

Isolation of cDNAs coding for three different forms of liver microsomal cytochrome P-450 from polychlorinated biphenyl-treated beagle dogs.

1990 • 51 citations

A comprehensive study of in vitro drug metabolism in several laboratory species.

1976 • 48 citations

Specificity of rat liver cytochrome P-450 isozymes in the mutagenic activation of benzo[a]pyrene, aromatic amines and aflatoxin B₁

1983 • 45 citations

Expression of cytochrome P-450_dbySaccharomyces cerevisiae

1986 • 25 citations

Expression of Alcohol-Inducible Rabbit Liver Cytochrome P-450 3a (P-450IIE1) inSaccharomyces cerevisiaewith the Copper-Inducible CUP1 Promoter

1990 • 25 citations

A novel form of cytochrome P-450 in Beagle dogs

1989 • 12 citations

Interspecies homology of liver microsomal cytochrome P-450

1989 • 11 citations

Species Differences in Activating and Inactivating Enzymes Related to In Vitro Mutagenicity Mediated by Tissue Preparations from These Species

1980 • 10 citations