Actinomycete cytochromes P‐450 involved in oxidative metabolism: Biochemistry and molecular biology∗

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

CLUSTAL: a package for performing multiple sequence alignment on a microcomputer

1988 • 3,446 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Characterization of a catalytically self-sufficient 119,000-dalton cytochrome P-450 monooxygenase induced by barbiturates in Bacillus megaterium.

1986 • 622 citations

A Soluble Cytochrome P-450 Functional in Methylene Hydroxylation

1968 • 438 citations

Key elements of the chemistry of cytochrome P-450: The oxygen rebound mechanism

1985 • 437 citations

Actinomycetes in Biotechnology

1988 • 331 citations

Identification and characterization of two functional domains in cytochrome P-450BM-3, a catalytically self-sufficient monooxygenase induced by barbiturates in Bacillus megaterium.

1987 • 326 citations

Glutathione Reductase from Human Erythrocytes

1982 • 238 citations

The Roles of Putidaredoxin and P450cam in Methylene Hydroxylation

1972 • 223 citations

A Transmissible Plasmid Controlling Camphor Oxidation in Pseudomonas putida

1973 • 212 citations

The roles of active site hydrogen bonding in cytochrome P-450cam as revealed by site-directed mutagenesis.

1988 • 199 citations

cDNA sequence of adrenodoxin reductase

1989 • 195 citations

An Erythromycin Derivative Produced by Targeted Gene Disruption in Saccharopolyspora erythraea

1991 • 164 citations

Putidaredoxin reductase and putidaredoxin. Cloning, sequence determination, and heterologous expression of the proteins.

1990 • 152 citations

Regioselectivity in the cytochromes P-450: Control by protein constraints and by chemical reactivities

1984 • 140 citations

The Enzymatic Hydroxylation of n-Octane by Corynebacterium sp. Strain 7E1C

1970 • 135 citations

Yeast cytochrome P-450 catalyzing lanosterol 14 alpha-demethylation. I. Purification and spectral properties.

1984 • 127 citations

Tertiary structure of Bacillus thermoproteolyticus [4Fe-4S] ferredoxin

1988 • 125 citations

Genes for two herbicide-inducible cytochromes P-450 from Streptomyces griseolus

1990 • 109 citations

Purification, characterization and biological activity of three forms of ferredoxin from the sulfate-reducing bacterium Desulfovibrio gigas

1976 • 108 citations

Characterization of a cytochrome P-450-dependent steroid hydroxylase system present in Bacillus megaterium.

1976 • 105 citations

Purification and characterization of cytochrome P‐450_sca from Streptomyces carbophilus

1989 • 104 citations

Molecular recognition in cytochrome P-450: alteration of regioselective alkane hydroxylation via protein engineering

1989 • 104 citations

Toluene dioxygenase: Purification of an iron-sulfur protein by affinity chromatography

1979 • 100 citations

Cytochrome P-450 Involvement in the Oxidation of n-Octane by Cell-free Extracts of Corynebacterium sp. Strain 7E1C

1968 • 95 citations

Nucleotide sequence of the gene for cholesterol oxidase from a Streptomyces sp

1989 • 92 citations

Progress in drug metabolism

1988 • 86 citations

Ferredoxins from two sulfonylurea herbicide monooxygenase systems in Streptomyces griseolus

1991 • 85 citations

Microbial Cytochromes P-450 and Xenobiotic Metabolism

1991 • 73 citations

Induction of cytochrome P-450 in Streptomycesgriseus by soybean flour

1986 • 72 citations

Stereoselective formation of a K-region dihydrodiol from phenanthrene by Streptomyces flavovirens

1990 • 65 citations

An operon containing the genes for cholesterol oxidase and a cytochrome P-450-like protein from a Streptomyces sp

1990 • 64 citations

Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus)

1987 • 63 citations

A two component-type cytochrome P-450 monooxygenase system in a prokaryote that catalyzes hydroxylation of ML-236B to pravastatin, a tissue-selective inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1991 • 62 citations

Structure of Azotobacter vinelandii 7Fe ferredoxin. Amino acid sequence and electron density maps of residues.

1983 • 60 citations

Identification of constitutive and herbicide inducible cytochromes P-450 in Streptomyces griseolus

1988 • 52 citations

Molecular Cloning and Sequence Determination of the lpd Gene Encoding Lipoamide Dehydrogenase from Pseudomonas fluorescens

1989 • 49 citations

Identification of a gene required for the terminal step in erythromycin A biosynthesis in Saccharopolyspora erythraea (Streptomyces erythreus)

1989 • 49 citations

Cytochrome P-450cam and Other Bacterial P-450 Enzymes

1986 • 49 citations

Cloning and Sequence Analysis of Adrenodoxin Reductase cDNA from Bovine Adrenal Cortex

1987 • 48 citations

Demethylation of Veratrole by Cytochrome P-450 in Streptomyces setonii

1986 • 48 citations

Purification and reconstitution of the electron transport components for 6-deoxyerythronolide B hydroxylase, a cytochrome P-450 enzyme of macrolide antibiotic (erythromycin) biosynthesis

1988 • 47 citations

Purification and characterization of a soybean flour-induced cytochrome P-450 from Streptomyces griseus

1989 • 46 citations

Xenobiotic oxidation by cytochrome P-450-enriched extracts of streptomyces griseus

1988 • 46 citations

Amino acid sequence of a four-iron-four-sulphur ferredoxin isolated from Bacillus stearothermophilus

1976 • 45 citations

Induction of cytochrome P-450-dependent sulfonylurea metabolism in Streptomyces griseolus

1986 • 45 citations

The demethylation of guaiacol by a new bacterial cytochrome P-450

1985 • 43 citations

Bacterial attack on phenolic ethers. Dealkylation of higher ethers and further observations on O-demethylases.

1971 • 31 citations

Complete amino acid sequence of the 4Fe-4S, thermostable ferredoxin from Clostridium thermoaceticum

1982 • 30 citations

Purification and characterization of a 7Fe ferredoxin from Streptomyces griseus

1990 • 29 citations

Reconstitution of iron-sulfur cluster of NADH-cytochrome c reductase, a component of benzoate 1,2-dioxygenase system from Pseudomonas arvilla C-1.

1981 • 27 citations

Cloning and characterization of the Saccharopolyspora erythraea fdxA gene encoding ferredoxin

1991 • 27 citations

The Crystal Structure of Cytochrome P-450cam

1986 • 26 citations

Primary structure of a 7Fe ferredoxin from Streptomyces griseus

1990 • 26 citations

Purification and characterization of a soybean flour-inducible ferredoxin reductase of Streptomyces griseus

1991 • 20 citations

Lack of regio- and stereospecificity in oxidation of (+) camphor by Streptomyces griseus enriched in cytochrome P-450soy

1990 • 20 citations

Activation of promutagenic chemicals by Streptomyces griseus containing cytochrome P-450soy

1990 • 18 citations

Phenobarbital and sulfonylurea-inducible operons encoding herbicide metabolizing cytochromes P-450 in Streptomyces griseolus

1992 • 17 citations

Bacterial attack on phenolic ethers. Electron acceptor-substrate binding proteins in bacterial O-dealkylases: purification and characterization of cytochrome P-450npd of Nocardia.

1974 • 17 citations

Structure and Reactions of a Microbial Monoxygenase: The Role of Putidaredoxin

1973 • 15 citations

Isolation and characterization of Streptomyces griseolus deletion mutants affected in cytochrome P-450-mediated herbicide metabolism

1991 • 15 citations

Bacterial attack on phenolic ethers. Resolution of a Nocardia O-demethylase and purification of a cytochrome P 450 component.

1971 • 15 citations

Bacterial attack on phenolic ethers. Preliminary studies on systems transporting electrons to the substrate binding components in bacterial O-dealkylases.

1974 • 11 citations

Activation and detection of (Pro)mutagenic chemicals using recombinant strains ofStreptomyces griseus

1992 • 11 citations

Involvement of an Inducible Cytochrome P-450 in Precocene II Oxidation by Streptomyces Griseus

1989 • 10 citations

CYTOCHROME P-450 IN ACINETOBACTER: OCCURRENCE, ISOLATION AND REGULATION

1985 • 3 citations