Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

Methods in Enzymology , Vol

1966 • 26,261 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Empirical Predictions of Protein Conformation

1978 • 3,167 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

1985 • 593 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

1985 • 301 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile.

1980 • 256 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family.

1985 • 181 citations

Human P450PCN1: Sequence, Chromosome Localization, and Direct Evidence through cDNA Expression That P450PCN1 Is Nifedipine Oxidase

1988 • 164 citations

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate.

1987 • 160 citations

On the substrate specificity of cytochrome P450IIIA1.

1988 • 134 citations

Characterization of mRNA Species Related to Human Liver Cytochrome P-450 Nifedipine Oxidase and the Regulation of Catalytic Activity

1989 • 123 citations

Molecular Cloning and Sequence Analysis of cDNA Containing the Entire Coding Region for Human Fetal Liver Cytochrome P-4501

1989 • 118 citations

Characterization of midazolam metabolism using human hepatic musomal fractions and hepatocytes in suspension obtained by perfusing whole human livers

1988 • 94 citations

Cytochrome P-450 isoenzyme content and monooxygenase activities in rat liver: effect of ontogenesis and pretreatment by phenobarbital and 3-methylcholanthrene.

1986 • 84 citations

Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family

1989 • 81 citations

Coinduction of multiple hepatic cytochrome P-450 proteins and their mRNAs in rats treated with imidazole antimycotic agents.

1989 • 76 citations

Monoclonal antibodies against human liver cytochrome P-450

1985 • 75 citations

Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes

1988 • 73 citations

Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response.

1983 • 66 citations

Human hepatic cytochrome P-450 composition as probed by in vitro microsomal metabolism of warfarin.

1984 • 58 citations

Immunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat

1987 • 55 citations

Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult

1988 • 53 citations

Optimal conditions for hybridization with oligonucleotides: A study with myc-oncogene DNA probes

1988 • 51 citations

Cloning of a cDNA coding for P-450 LM3c from rabbit liver microsomes and regulation of its expression

1986 • 32 citations

Complete Sequence of Cytochrome P450 3c cDNA and Presence of Two mRNA Species with 3′ Untranslated Regions of Different Lengths

1988 • 29 citations

Immunochemical similarity of P-450 HFLa, a form of cytochrome P-450 in human fetal livers, to a form of rat liver cytochrome P-450 inducible by macrolide antibiotics

1988 • 24 citations