The CYP2D gene subfamily: analysis of the molecular basis of the debrisoquine 4-hydroxylase deficiency in DA rats

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Genomic sequencing.

1984 • 8,343 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

RNA molecular weight determinations by gel electrophoresis under denaturing conditions, a critical reexamination

1977 • 3,548 citations

A general method for isolation of high molecular weight DNA from eukaryotes

1976 • 2,827 citations

Efficient isolation of genes by using antibody probes.

1983 • 2,065 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins

1985 • 1,253 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Characterization of the common genetic defect in humans deficient in debrisoquine metabolism

1988 • 717 citations

High efficiency polyoma DNA transfection of chloroquine treated cells

1983 • 711 citations

The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

1989 • 609 citations

Random subcloning of sonicated DNA: Application to shotgun DNA sequence analysis

1983 • 605 citations

MEDICAL NEMESIS

1974 • 377 citations

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

1986 • 299 citations

Antibodies against human cytochrome P-450db1 in autoimmune hepatitis type II.

1988 • 237 citations

Two mutant alleles of the human cytochrome P-450db1 gene (P450C2D1) associated with genetically deficient metabolism of debrisoquine and other drugs.

1988 • 199 citations

Absence of hepatic cytochrome P450bufI causes genetically deficient debrisoquine oxidation in man

1988 • 152 citations

Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism

1984 • 150 citations

Structural Characteristics of Cytochrome P-450. Possible Location of the Heme-Binding Cysteine in Determined Amino-Acid Sequences

1983 • 146 citations

Animal modelling of human polymorphic drug oxidation—the metabolism of debrisoquine and phenacetin in rat inbred strains

1981 • 141 citations

Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism

1987 • 139 citations

Gene conversion in a cytochrome P-450 gene family.

1986 • 56 citations

Sex and strain differences in hepatic debrisoquine 4-hydroxylase activity of the rat.

1985 • 52 citations

At least six forms of extremely homologous cytochromes P-450 in rat liver are encoded at two closely linked genetic loci.

1983 • 41 citations

Bufuralol 1'-hydroxylase activity of the rat

1986 • 33 citations

Southern Analysis of Genomic DNA with Unique and Degenerate Oligonucleotide Probes: A Method for Reducing Probe Degeneracy

1988 • 22 citations

Polymorphisms of four hepatic cytochromes P-450 in twenty-eight inbred strains of rat

1987 • 21 citations

Four species of cDNAs for cytochrome P450 isozymes immunorelated to P450C-M/F encode for members of P450IID subfamily, increasing the number of members within the subfamily

1988 • 17 citations