Localization of cytochrome P-450 gene expression in normal and diseased human liver byin situ hybridization of wax-embedded archival material

A membrane-filter technique for the detection of complementary DNA

1966 • 3,996 citations

The molecular biology of cytochrome P450s.

1988 • 1,294 citations

The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature

1991 • 1,092 citations

Progress in Liver Disease

1970 • 826 citations

The P450 Gene Superfamily: Recommended Nomenclature

1987 • 812 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

In situ hybridization : applications to neurobiology

1987 • 249 citations

Mammalian cytochromes P-450

1987 • 248 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.

1988 • 229 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats.

1981 • 150 citations

Growth in culture and tumorigenicity after transfection with the ras oncogene of liver epithelial cells from carcinogen-treated rats.

1987 • 116 citations

Stem cell biology, hormone/matrix synergies and liver differentiation

1990 • 99 citations

In situ hybridization of immunoglobulin light chain mRNA in paraffin sections using biotinylated or hapten‐labelled oligonucleotide probes

1990 • 84 citations

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

1988 • 76 citations

Detection of albumin mRNAs in rat liver by in situ hybridization: usefulness of paraffin embedding and comparison of various fixation procedures.

1987 • 68 citations

Positional and developmental regulation of glutamine synthetase expression in mouse liver.

1988 • 66 citations

Human cytochrome P-450 4 mRNA and gene: part of a multigene family that contains Alu sequences in its mRNA.

1986 • 65 citations

Evidence that Interaction of Hepatocytes with the Collecting (Hepatic) Veins Triggers Position-Specific Transcription of the Glutamine Synthetase and Ornithine Aminotransferase Genes in the Mouse Liver

1991 • 63 citations

Isolation and sequence of a human cytochrome P-450 cDNA clone.

1985 • 59 citations

Induction of digitoxigenin monodigitoxoside UDP-glucuronosyltransferase activity by glucocorticoids and other inducers of cytochrome P-450p in primary monolayer cultures of adult rat hepatocytes and in human liver.

1986 • 56 citations

In situ hybridization: Principles and practice

1990 • 55 citations

Evidence that interaction of hepatocytes with the collecting (hepatic) veins triggers position-specific transcription of the glutamine synthetase and ornithine aminotransferase genes in the mouse liver.

1991 • 49 citations

Drug Metabolizing Enzymes: Genetics, Regulation and Toxicology

1990 • 41 citations

A quantitative ‘in-situ’ hybridization method using computer-assisted image analysis. Validation and measurement of atrial-natriuretic-factor mRNA in the rat heart

1989 • 39 citations

Immunohistochemical localization of cytochrome P-450a in liver sections from untreated rats and rats treated with phenobarbital or 3-methylcholanthrene.

1983 • 31 citations

Zonal Signal Heterogeneity and Induction of Hepatocyte Heterogeneity

1986 • 28 citations

Enhanced drug-metabolizing capacity within liver adjacent to human and rat liver tumors.

1980 • 27 citations

Use of sulfonated probes for in situ detection of amylase mRNA in formalin-fixed paraffin sections of human pancreas and submaxillary gland.

1987 • 26 citations

The major phenobarbital‐inducible cytochrome P‐450 gene subfamily (P450IIB) mapped to the long arm of human chromosome 19

1988 • 26 citations

Zonal hepatic function: solute-hepatocyte interactions within the liver acinus.

1982 • 25 citations

Cloning, experession and chromosomal localization of a member of the human cytochrome P450IIC gene sub-family

1989 • 15 citations

Embryonic control of cancer.

1986 • 12 citations

Quantification of cytochrome P-450 gene expression in human tissues

1990 • 6 citations

Structure and expression of genes coding for members of the human P450II family

1989 • 2 citations

Structure and expression of human cytochrome P-450 genes

1987 • 1 citations