Absence of CYP3 A Genetic Polymorphism Assessed by Urinary Excretion of 6 β‐Hydroxycortisol in 102 Healthy Subjects on Rifampicin

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

1986 • 734 citations

Cyclosporine metabolism in human liver: Identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs

1988 • 539 citations

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1989 • 528 citations

Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6β-hydroxylase cytochrome P-450 enzyme

1988 • 413 citations

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3).

1990 • 402 citations

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 • 367 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

The increase in urinary excretion of 6 beta‐hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction.

1989 • 334 citations

Identification of an inducible form of cytochrome P-450 in human liver.

1985 • 320 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Oxidation of quinidine by human liver cytochrome P-450.

1986 • 296 citations

Genetic polymorphism of S-mephenytoin hydroxylation

1989 • 292 citations

Characterization of Human Microsomal Cytochrome P-450 Enzymes

1989 • 244 citations

Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450.

1988 • 229 citations

Laboratory Methods in Antimicrobial Chemotherapy

1979 • 225 citations

Identification of a polymorphically expressed member of the human cytochrome P-450III family.

1989 • 224 citations

Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae

1990 • 207 citations

Variability in nifedipine pharmacokinetics and dynamics: A new oxidation polymorphism in man

1984 • 182 citations

Lidocaine metabolism by human cytochrome P-450s purified from hepatic microsomes: comparison of those with rat hepatic cytochrome P-450s.

1990 • 141 citations

The genetic polymorphism of debrisoquine/sparteine metabolism—molecular mechanisms

1990 • 129 citations

Estradiol Metabolism by Complementary Deoxyribonucleic Acid-Expressed Human Cytochrome P450s

1990 • 129 citations

Urinary excretion of 6?-hydroxycortisol and the time course measurement of enzyme induction in man

1989 • 113 citations

The erythromycin breath test as a predictor of cyclosporine blood levels

1990 • 99 citations

Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects

1988 • 90 citations

Nifedipine: Variability in its kinetics and metabolism in man

1989 • 35 citations

The measurement, excretion, and source of urinary 6-hydroxycortisol in humans

1969 • 34 citations

ELISA of 6-beta-hydroxycortisol in human urine: Diurnal variations and effects of antiepileptic therapy

1986 • 29 citations

Selection of subjects for investigation of host factors affecting drug response: A method to identify new pharmacogenetic conditions

1984 • 14 citations

6-hydroxylation of cortisol and urinary 6β-hydroxycortisol

1978 • 14 citations

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