Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

The 2.6-A crystal structure of Pseudomonas putida cytochrome P-450.

1985 • 815 citations

High efficiency polyoma DNA transfection of chloroquine treated cells

1983 • 711 citations

Efficient infection of monkey cells with DNA of simian virus 40.

1981 • 419 citations

Primary structure of a cytochrome P-450: coding nucleotide sequence of phenobarbital-inducible cytochrome P-450 cDNA from rat liver.

1982 • 275 citations

The roles of active site hydrogen bonding in cytochrome P-450cam as revealed by site-directed mutagenesis.

1988 • 199 citations

Amino acid sequence of an analogous peptide from two forms of cytochrome P-450.

1981 • 123 citations

Molecular recognition in cytochrome P-450: alteration of regioselective alkane hydroxylation via protein engineering

1989 • 104 citations

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

1989 • 102 citations

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

1988 • 90 citations

The Structure and Characterization of Type I P-45015α Gene as Major Steroid 15α-Hydroxylase and Its Comparison with Type II P-45015α Gene

1989 • 77 citations

A single amino acid substitution converts cytochrome P45014DM to an inactive form, cytochrome P450SG1: Complete primary structures deduced from cloned DNAs

1988 • 64 citations

Mouse liver testosterone 16 alpha-hydroxylase (cytochrome P-450(16) alpha). Purification, regioselectivity, stereospecificity, and immunochemical characterization.

1984 • 57 citations

The importance of threonine‐301 from cytochromes P‐450 (laurate (ω‐1)‐hydroxylase and testosterone 16α‐hydroxylase) in substrate binding as demonstrated by site‐directed mutagenesis

1988 • 44 citations

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

1985 • 36 citations

Substrate specificities of cytochrome P-450, C-P-45016α and P-45015α, and contribution to steroid hydroxylase activities in mouse liver microsomes

1988 • 21 citations

Genetic regulation of testosterone 15.alpha.-hydroxylase (cytochrome P-45015.alpha.) in renal microsomes of female mice

1986 • 8 citations