Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

1997 • 7,814 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Neurogenesis in the adult human hippocampus

1998 • 6,181 citations

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

1965 • 3,461 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Navigation-related structural change in the hippocampi of taxi drivers

2000 • 3,075 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Ferrier lecture - Functional architecture of macaque monkey visual cortex

1977 • 2,599 citations

SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE

1963 • 2,565 citations

Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity

1990 • 2,131 citations

CORTICAL PLASTICITY: From Synapses to Maps

1998 • 2,096 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

1997 • 1,880 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Direct Mechanical Measurements of the Elasticity of Single DNA Molecules by Using Magnetic Beads

1992 • 1,755 citations

15-year longitudinal study of blood pressure and dementia

1996 • 1,706 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

Plasticity of ocular dominance columns in monkey striate cortex

1977 • 1,630 citations

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

1988 • 1,518 citations

Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes

1998 • 1,507 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 • 1,483 citations

Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

1997 • 1,468 citations

Neurogenesis in the Adult Rat: Electron Microscopic Analysis of Light Radioautographs

1977 • 1,438 citations

Use-dependent alterations of movement representations in primary motor cortex of adult squirrel monkeys

1996 • 1,438 citations

Developmental mechanisms that generate precise patterns of neuronal connectivity

1993 • 1,435 citations

Folate, Vitamin B12, and Serum Total Homocysteine Levels in Confirmed Alzheimer Disease

1998 • 1,432 citations

Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.

1993 • 1,426 citations

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

1998 • 1,386 citations

BINOCULAR INTERACTION IN STRIATE CORTEX OF KITTENS REARED WITH ARTIFICIAL SQUINT

1965 • 1,377 citations

Influence of Education and Occupation on the Incidence of Alzheimer's Disease

1994 • 1,373 citations

Experience and Brain Development

1987 • 1,346 citations

Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia.

1993 • 1,319 citations

CADHERINS: A MOLECULAR FAMILY IMPORTANT IN SELECTIVE CELL-CELL ADHESION

1990 • 1,293 citations

GAP-43: an intrinsic determinant of neuronal development and plasticity

1997 • 1,285 citations

Notch Signaling

1995 • 1,282 citations

EFFECTS OF VISUAL DEPRIVATION ON MORPHOLOGY AND PHYSIOLOGY OF CELLS IN THE CAT'S LATERAL GENICULATE BODY

1963 • 1,280 citations

The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

1995 • 1,266 citations

Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat

1993 • 1,215 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the unanaesthetized rabbit following stimulation of the perforant path

1973 • 1,140 citations

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

1998 • 1,135 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Scrapie prion protein contains a phosphatidylinositol glycolipid

1987 • 1,104 citations

Apolipoprotein E polymorphism and Alzheimer's disease

1993 • 1,076 citations

Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus

1988 • 1,068 citations

Surface Modulation in Cell Recognition and Cell Growth

1976 • 1,062 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Identification of two distinct synucleins from human brain

1994 • 1,031 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

1999 • 964 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

Functional reorganization of primary somatosensory cortex in adult owl monkeys after behaviorally controlled tactile stimulation

1990 • 943 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

The Association Between Midlife Blood Pressure Levels and Late-Life Cognitive Function

1995 • 885 citations

The incidence of dementia

1998 • 862 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

How patterned neural connections can be set up by self-organization

1976 • 838 citations

Characterization of a novel protein regulated during the critical period for song learning in the zebra finch

1995 • 826 citations

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

1996 • 817 citations

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

1983 • 811 citations

Prion protein is necessary for normal synaptic function

1994 • 802 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Topographic reorganization of the hand representation in cortical area 3b owl monkeys trained in a frequency-discrimination task

1992 • 786 citations

Prevalence of Alzheimer's disease and vascular dementia: association with education. The Rotterdam study

1995 • 786 citations

Impulse activity and the patterning of connections during cns development

1990 • 770 citations

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and disease

1998 • 756 citations

Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation

1989 • 749 citations

Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population

1989 • 746 citations

Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.

1990 • 735 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease

1998 • 722 citations

Presenilin 1 is required for Notch 1 and Dll1 expression in the paraxial mesoderm

1997 • 721 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization

1997 • 698 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6

1995 • 657 citations

The Reorganization of Somatosensory Cortex Following Peripheral Nerve Damage in Adult and Developing Mammals

1983 • 653 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Cell Adhesion Molecules in the Regulation of Animal Form and Tissue Pattern

1986 • 630 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Genetic influence on neurogenesis in the dentate gyrus of adult mice

1997 • 624 citations

Linguistic Ability in Early Life and Cognitive Function and Alzheimer's Disease in Late Life

1996 • 620 citations

STAT3 Serine Phosphorylation by ERK-Dependent and -Independent Pathways Negatively Modulates Its Tyrosine Phosphorylation

1997 • 612 citations

Synaptic tagging: implications for late maintenance of hippocampal long-term potentiation

1998 • 603 citations

An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses.

1994 • 603 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

1991 • 582 citations

PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity

1996 • 582 citations

Analysis of cell cycle-related gene expression in postmitotic neurons: Selective induction of cyclin D1 during programmed cell death

1994 • 576 citations

Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices

1987 • 569 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

Hippocampal long-term potentiation and neural cell adhesion molecules L1 and NCAM

1994 • 557 citations

OBSERVATIONS ON THE EXCITABLE CORTEX OF THE CHIMPANZEE, ORANG‐UTAN, AND GORILLA

1917 • 557 citations

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 • 557 citations

β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury

1993 • 557 citations

Mutations of cell cycle regulators. Biological and clinical implications for human neoplasia.

1995 • 549 citations

MAP Kinase Translocates into the Nucleus of the Presynaptic Cell and Is Required for Long-Term Facilitation in Aplysia

1997 • 548 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Synapse replacement in the nervous system of adult vertebrates.

1981 • 545 citations

Pattern of dendritic branching in occipital cortex of rats reared in complex environments

1973 • 537 citations

Ectopic Cell Cycle Proteins Predict the Sites of Neuronal Cell Death in Alzheimer’s Disease Brain

1998 • 537 citations

Loss of the Presynaptic Vesicle Protein Synaptophysin in Hippocampus Correlates with Cognitive Decline in Alzheimer Disease

1997 • 535 citations

The occult aftermath of boxing.

1990 • 522 citations

Prenatal Tetrodotoxin Infusion Blocks Segregation of Retinogeniculate Afferents

1988 • 521 citations

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition

1995 • 515 citations

Mechanisms and Molecules that Control Growth Cone Guidance

1996 • 515 citations

Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1998 • 512 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

1993 • 504 citations

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

1996 • 500 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 • 497 citations

Effects of environmental complexity and training on brain chemistry and anatomy: A replication and extension.

1962 • 496 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Seasonal recruitment of hippocampal neurons in adult free-ranging black-capped chickadees.

1994 • 488 citations

A Molecular Redox Switch on p21

1997 • 488 citations

Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells

1995 • 484 citations

Isoforms of nitric oxide synthase

1995 • 482 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Signaling through focal adhesion kinase

1997 • 468 citations

Nearly ubiquitous tissue distribution of the scrapie agent precursor protein

1992 • 468 citations

Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia

1979 • 466 citations

Mice lacking both presenilin genes exhibitearlyembryonic patterningdefects

1999 • 462 citations

Morphoregulatory molecules

1988 • 460 citations

Plasticity of Hippocampal Circuitry in Alzheimer's Disease

1985 • 457 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus

1984 • 453 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Aberrant Expression of Mitotic Cdc2/Cyclin B1 Kinase in Degenerating Neurons of Alzheimer’s Disease Brain

1997 • 444 citations

Neuroplasticity Failure in Alzheimer's Disease

1999 • 442 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Mitogen-activated protein kinases: versatile transducers for cell signaling

1992 • 439 citations

Synucleins in synaptic plasticity and neurodegenerative disorders

1999 • 430 citations

Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections

1988 • 429 citations

Regulation of Phospholipase D2: Selective Inhibition of Mammalian Phospholipase D Isoenzymes by α- and β-Synucleins

1998 • 427 citations

Axon pathology in Parkinson’s disease and Lewy body dementia hippocampus contains α-, β-, and γ-synuclein

1999 • 417 citations

Abnormal expression of the cell cycle regulators P16 and CDK4 in Alzheimer's disease.

1997 • 417 citations

Quantitative assessment of cortical synaptic density in Alzheimer's disease

1990 • 415 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

Neuropathological Diagnostic Criteria for Creutzfeldt‐Jakob Disease (CJD) and Other Human Spongiform Encephalopathies (Prion Diseases)

1995 • 412 citations

A Model for Central Synaptic Junctional Complex Formation Based on the Differential Adhesive Specificities of the Cadherins

1996 • 411 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

1985 • 407 citations

Synaptic loss in Alzheimer's disease and other dementias

1989 • 406 citations

Phospholipase D: enzymology, mechanisms of regulation, and function

1997 • 405 citations

Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

1995 • 403 citations

Distribution and possible roles of the highly polysialylated neural cell adhesion molecule (NCAM-H) in the developing and adult central nervous system

1993 • 402 citations

Src family protein tyrosine kinases: cooperating with growth factor and adhesion signaling pathways

1997 • 401 citations

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1994 • 393 citations

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

1996 • 390 citations

Structural Correlates of Cognition in Dementia: Quantification and Assessment of Synapse Change

1996 • 387 citations

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1991 • 386 citations

Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus

1998 • 385 citations

Mitotic mechanisms in Alzheimer's disease?

1996 • 384 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

Association of midlife blood pressure to late-life cognitive decline and brain morphology

1998 • 381 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

1998 • 373 citations

Nitric Oxide-stimulated Guanine Nucleotide Exchange on p21ras

1995 • 367 citations

Basic FGF in adult rat brain: cellular distribution and response to entorhinal lesion and fimbria-fornix transection

1992 • 367 citations

Dependence of Cortical Plasticity on Correlated Activity of Single Neurons and on Behavioral Context

1992 • 366 citations

Synaptic and neuritic alterations during the progression of Alzheimer's disease

1994 • 355 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Structural roles of acetylcholinesterase variants in biology and pathology

1999 • 353 citations

Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease

1989 • 353 citations

L'homme neuronal

1983 • 352 citations

Evidence of Presynaptic Location and Function of the Prion Protein

1999 • 350 citations

Modification of retinal ganglion cell axon morphology by prenatal infusion of tetrodotoxin

1988 • 350 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

A Necessity for MAP Kinase Activation in Mammalian Spatial Learning

1999 • 346 citations

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the β-amyloid precursor protein

1999 • 346 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

Development of neuronal selectivity in primary visual cortex of cat.

1984 • 336 citations

Extracellular Signal-Regulated Kinase (ERK) Controls Immediate Early Gene Induction on Corticostriatal Stimulation

1998 • 335 citations

Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species

1996 • 332 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Regional mapping of prion proteins in brain.

1992 • 329 citations

Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing.

1997 • 328 citations

Neural Cell Adhesion Molecule-Stimulated Neurite Outgrowth Depends on Activation of Protein Kinase C and the Ras–Mitogen-Activated Protein Kinase Pathway

2000 • 328 citations

Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide

1993 • 327 citations

The rat brain synucleins; family of proteins transiently associated with neuronal membrane

1991 • 326 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

NACP, a presynaptic protein, immunoreactivity in Lewy bodies in Parkinson's disease

1997 • 322 citations

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

1994 • 321 citations

Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer’s Disease Carrying Apolipoprotein ε4 Allele

1997 • 321 citations

Cell cycle markers in the hippocampus in Alzheimer's disease

1997 • 315 citations

Mapping of the distribution of polysialylated neural cell adhesion molecule throughout the central nervous system of the adult rat: An immunohistochemical study

1992 • 309 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

The Organization of Neocortex in Mammals: Implications for Theories of Brain Function

1987 • 307 citations

Behavioral and anatomical deficits in mice homozygous for a modified ?-amyloid precursor protein gene

1994 • 307 citations

Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development—A study of molecular forms

1992 • 307 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Action Potential-Dependent Regulation of Gene Expression: Temporal Specificity in Ca²⁺, cAMP-Responsive Element Binding Proteins, and Mitogen-Activated Protein Kinase Signaling

1997 • 304 citations

Construction of epithelioid sheets by transfection of mouse sarcoma cells with cDNAs for chicken cell adhesion molecules.

1988 • 301 citations

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1997 • 299 citations

Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor

1991 • 298 citations

Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells

1993 • 293 citations

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

1991 • 292 citations

In vivo visualization of pre- and postsynaptic changes during synapse elimination in reinnervated mouse muscle

1989 • 290 citations

Risk factors for late‐ onset Alzheimer's disease: A population‐ based, case‐control study

1993 • 289 citations

NCAM Is Essential for Axonal Growth and Fasciculation in the Hippocampus

1997 • 289 citations

Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation

2000 • 285 citations

Molecular biology and pathogenesis of prion diseases

1996 • 279 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Topobiology: an introduction to molecular embryology

1989 • 278 citations

Relationship between lifetime occupation and parietal flow

1995 • 277 citations

On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer's disease

1985 • 276 citations

Brain aging and Alzheimer's disease, “Wear and tear” versus “Use it or lose it”

1991 • 274 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1999 • 273 citations

Frequency discrimination training engaging a restricted skin surface results in an emergence of a cutaneous response zone in cortical area 3a

1992 • 272 citations

Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt-Jakob disease.

1992 • 271 citations

Visualization of neuromuscular junctions over periods of several months in living mice

1987 • 270 citations

The Changing View of Neural Specificity

1985 • 269 citations

Sensory experience modifies the short-term dynamics of neocortical synapses

1999 • 266 citations

TheDrosophilaβ-Amyloid Precursor Protein Homolog Promotes Synapse Differentiation at the Neuromuscular Junction

1999 • 265 citations

Notch as a Mediator of Cell Fate Determination in Hematopoiesis: Evidence and Speculation

1999 • 265 citations

Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path

1998 • 263 citations

Differential release of cellular and scrapie prion proteins from cellular membranes by phosphatidylinositol-specific phospholipase C

1990 • 263 citations

Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites

1991 • 259 citations

Thalamic and Brainstem Contributions to Large-Scale Plasticity of Primate Somatosensory Cortex

1998 • 257 citations

Nitric Oxide Regulates Cell Proliferation during Drosophila Development

1996 • 255 citations

Arbiter of differentiation and death: Notch signaling meets apoptosis

1999 • 255 citations

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

1994 • 252 citations

The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.

1997 • 250 citations

Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro.

1995 • 248 citations

Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein

1999 • 247 citations

Synapse loss in the temporal lobe in Alzheimer's disease

1993 • 247 citations

Altered axons and axon terminals in the lateral vestibular nucleus of the rat. Possible example of axonal remodeling.

1971 • 246 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion

1991 • 244 citations

Topobiology: An Introduction To Molecular Embryology

1988 • 244 citations

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer’s Disease

1998 • 241 citations

Patterns of aberrant sprouting in alzheimer's disease

1991 • 241 citations

Neurite Outgrowth Stimulated by Neural Cell Adhesion Molecules Requires Growth-Associated Protein-43 (GAP-43) Function and Is Associated with GAP-43 Phosphorylation in Growth Cones

1998 • 239 citations

Notch1-Induced Delay of Human Hematopoietic Progenitor Cell Differentiation Is Associated With Altered Cell Cycle Kinetics

1999 • 236 citations

A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

1993 • 235 citations

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease

1993 • 234 citations

Delayed localization of synelfin (synuclein, NACP) to presynaptic terminals in cultured rat hippocampal neurons

1997 • 234 citations

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

1997 • 233 citations

Expression of rat apolipoprotein A-IV and A-I genes: mRNA induction during development and in response to glucocorticoids and insulin.

1985 • 231 citations

Scrapie PrP 27-30 is a sialoglycoprotein

1985 • 231 citations

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

1997 • 227 citations

Cellular prion protein localization in rodent and primate brain

1998 • 222 citations

Genetic susceptibility and head injury as risk factors for Alzheimer's disease among community‐dwelling elderly persons and their first‐degree relatives

1993 • 221 citations

Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

1999 • 221 citations

Hyperphosphorylation of Tau in PHF

1995 • 220 citations

Progressive improvement in discriminative abilities in adult owl monkeys performing a tactile frequency discrimination task

1992 • 220 citations

A Case-Control Study of Alzheimer's Disease in Japan – Significance of Life-Styles

1994 • 218 citations

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

1995 • 218 citations

Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1992 • 217 citations

Notch1 inhibits neurite outgrowth in postmitotic primary neurons

1999 • 215 citations

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

1992 • 215 citations

Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein.

1994 • 213 citations

Rapidly progressing atrophy of medial temporal lobe in Alzheimer's disease

1994 • 213 citations

NCAM stimulates the ras-MAPK pathway and CREB phosphorylation in neuronal cells

1999 • 213 citations

Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain.

1988 • 212 citations

Different patterns of truncated prion protein fragments correlate with distinct phenotypes in P102L Gerstmann–Sträussler–Scheinker disease

1998 • 210 citations

Fluorescent probes that stain living nerve terminals

1987 • 210 citations

Lipoprotein Uptake by Neuronal Growth Cones in Vitro

1987 • 209 citations

Dynamic changes in the dendritic geometry of individual neurons visualized over periods of up to three months in the superior cervical ganglion of living mice

1986 • 209 citations

The neural cell adhesion molecule in synaptic plasticity and ageing

2000 • 209 citations

Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat

1991 • 207 citations

Sex differences in the dendritic branching of dentate granule cells following differential experience

1985 • 207 citations

14-3-3: Modulators of Signaling Proteins?

1994 • 206 citations

Learning-Dependent Synaptic Modifications in the Cerebellar Cortex of the Adult Rat Persist for at Least Four Weeks

1997 • 205 citations

Cell death and the cell cycle: a relationship between transformation and neurodegeneration?

1993 • 205 citations

Characterization of the Precursor Protein of the Non-Aβ Component of Senile Plaques (NACP) in the Human Central Nervous System

1996 • 202 citations

Heavy Drinking as a Risk Factor for Depression and Dementia in Elderly Men

1991 • 201 citations

Loss of Proteins Regulating Synaptic Plasticity in Normal Aging of the Human Brain and in Alzheimer Disease

1999 • 199 citations

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.

1992 • 199 citations

The Neuropathology and Epidemiology of Bovine Spongiform Encephalopathy

1995 • 199 citations

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension

1994 • 197 citations

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

1995 • 196 citations

What the evolution of the amyloid protein precursor supergene family tells us about its function

2000 • 196 citations

Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region

1983 • 194 citations

ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

1989 • 192 citations

Nitric oxide mediatesN-methyl-<scp>d</scp>-aspartate receptor-induced activation of p21^ras

1998 • 192 citations

Plasticity in the organization of adult cerebral cortical maps: a computer simulation based on neuronal group selection

1987 • 191 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Stroke and Cocaine or Amphetamine Use

1998 • 190 citations

Disappearance of actin‐binding protein, drebrin, from hippocampal synapses in alzheimer's disease

1996 • 189 citations

Cerebral Amyloid Induces Aberrant Axonal Sprouting and Ectopic Terminal Formation in Amyloid Precursor Protein Transgenic Mice

1999 • 189 citations

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.

1999 • 189 citations

Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele

1996 • 189 citations

Cholinesterases and the Pathology of Alzheimer Disease

1995 • 188 citations

The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity

1997 • 187 citations

Cholinergic sprouting in the hippocampus: A proposed role for IL-1

1990 • 187 citations

CAMs and Igs: Cell Adhesion and the Evolutionary Origins of Immunity

1987 • 187 citations

The Canadian Study of Health and Aging

1997 • 185 citations

Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

1992 • 185 citations

Developmental Changes in τ Phosphorylation: Fetal τ Is Transiently Phosphorylated in a Manner Similar to Paired Helical Filament‐τ Characteristic of Alzheimer's Disease

1993 • 184 citations

Neuronal nitric oxide synthase is induced in spinal neurons by traumatic injury

1994 • 184 citations

Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in alzheimer's disease

1995 • 183 citations

Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's disease

1987 • 183 citations

Three-Dimensional Analysis of the Relationship Between Synaptic Pathology and Neuropil Threads in Alzheimer Disease

1992 • 180 citations

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

1992 • 180 citations

Early-life risk factors and the development of Alzheimer’s disease

2000 • 180 citations

The Contribution of Altered Synapses in the Senile Plaque: An Electron Microscopic Study in Alzheimer's Dementia^*†

1967 • 179 citations

S100β protein expression in Alzheimer disease: Potential role in the pathogenesis of neuritic plaques

1994 • 179 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Incidence and relative risk of dementia in an urban elderly population: findings of a prospective field study

1994 • 178 citations

Mitotic phosphoepitopes precede paired helical filaments in Alzheimer’s disease

1998 • 177 citations

Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease

1987 • 176 citations

Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelmässige Veränderung der Hirnrinde bei seniler Demenz.

1907 • 176 citations

Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.

1994 • 176 citations

Regional synaptic pathology in Alzheimer's disease

1992 • 176 citations

TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration

1993 • 174 citations

Dendritic sprouting in Alzheimer's presenile dementia

1978 • 174 citations

Basic fibroblast growth factor in Alzheimer's disease

1990 • 173 citations

Postnatal construction of neural circuitry in the mouse olfactory bulb

1990 • 173 citations

Neurochemical Dissection of Synaptic Pathology in Alzheimer's Disease

1998 • 171 citations

Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism

1996 • 171 citations

Learning-induced changes of auditory receptive fields

1993 • 171 citations

Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

1997 • 171 citations

Mechanisms of synaptic dysfunction in Alzheimer's disease.

1995 • 170 citations

Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development

1997 • 170 citations

STUDIES ON THE COMPARATIVE ANATOMY OF THE GANGLION BASALE OF MEYNERT

1963 • 169 citations

Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism

1997 • 169 citations

Expression Pattern of Synucleins (Non‐Aβ Component of Alzheimer's Disease Amyloid Precursor Protein/α‐Synuclein) During Murine Brain Development

1998 • 169 citations

Evidence for a physical interaction between presenilin and Notch

1999 • 168 citations

Arg-Gly-Asp-Ser-Selective Adhesion and the Stabilization of Long-Term Potentiation: Pharmacological Studies and the Characterization of a Candidate Matrix Receptor

1997 • 168 citations

Non-Aβ Component of Alzheimer's Disease Amyloid (NAC) Revisited

1999 • 167 citations

Dopamine and Serotonin Systems in Human and Rodent Brain: Effects of Age and Neurodegenerative Disease

1987 • 167 citations

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein

1995 • 166 citations

Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease.

1996 • 166 citations

Induction of the Cyclin-dependent Kinase Inhibitor p21 by Nitric Oxide-generating Vasodilator in Vascular Smooth Muscle Cells

1997 • 165 citations

Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease

1991 • 165 citations

Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia

1987 • 164 citations

Senile plaques as aberrant sprout-stimulating structures

1986 • 161 citations

Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

1994 • 161 citations

Discussion

1998 • 161 citations

The central adaptation syndrome: Psychosocial stress as a trigger for adaptive modifications of brain structure and brain function

1996 • 160 citations

The extent of phosphorylation of fetal tau is comparable to that of PHF-tau from Alzheimer paired helical filaments

1993 • 160 citations

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

1994 • 160 citations

NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1

1995 • 160 citations

Direct association of presenilin‐1 with β‐catenin

1998 • 159 citations

Synaptic pathology in alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles

1992 • 159 citations

Microtubular reorganization and dendritic growth response in alzheimer's disease

1989 • 159 citations

The Amyloid Precursor Protein Is Developmentally Regulated and Correlated with Synaptogenesis

1994 • 158 citations

Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin‐1 Mutant Mice

1999 • 157 citations

Lesion-induced plasticity of central neurons: sprouting of single fibres in the rat hippocampus after unilateral entorhinal cortex lesion

1997 • 157 citations

Presenilin 1 Facilitates the Constitutive Turnover of β-Catenin: Differential Activity of Alzheimer’s Disease–Linked PS1 Mutants in the β-Catenin–Signaling Pathway

1999 • 156 citations

Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype

1998 • 155 citations

Association of education with incidence of cognitive impairment in three established populations for epidemiologic studies of the elderly

1994 • 154 citations

Secreted forms of β‐amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

1994 • 154 citations

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1998 • 154 citations

Presenilins and Alzheimer’s disease: biological functions and pathogenic mechanisms

2000 • 152 citations

Neurodegenerative diseases: occupational occurrence and potential risk factors, 1982 through 1991.

1996 • 152 citations

A Novel, Nerve Growth Factor-activated Pathway Involving Nitric Oxide, p53, and p21WAF1 Regulates Neuronal Differentiation of PC12 Cells

1997 • 152 citations

The dendritic morphology of pyramidal neurons in the rat hippocampal CA3 area. II. Effects of gender and the environment

1989 • 151 citations

Cortical Synaptic Changes and Gliosis in Normal Aging, Alzheimer's Disease and Frontal Lobe Degeneration

1996 • 151 citations

Relationship of Age, Education, and Occupation With Dementia Among a Community-Based Sample of African Americans

1996 • 151 citations

Notch Is Expressed in Adult Brain, Is Coexpressed with Presenilin-1, and Is Altered in Alzheimer Disease

1998 • 150 citations

Neurodegeneration and cognitive impairment in apoE-deficient mice is ameliorated by infusion of recombinant apoE

1997 • 148 citations

β‐Amyloid Precursor Protein Isoforms in Various Rat Brain Regions and During Brain Development

1992 • 148 citations

Neural activity and the growth of the brain

1995 • 146 citations

Nitric oxide synthase in motor neurons after axotomy.

1994 • 146 citations

Insulin-like growth factors and insulin-like growth factor binding proteins in cerebrospinal fluid and serum of patients with dementia of the Alzheimer type

1993 • 145 citations

Altered expression of transforming growth factor-beta in Alzheimer's disease

1995 • 144 citations

Intraneuronal compartments of the amyloid precursor protein

1993 • 143 citations

Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase

1998 • 143 citations

Hippocampal NCAM180 transiently increases sialylation during the acquisition and consolidation of a passive avoidance response in the adult rat

1992 • 143 citations

Severe learning deficits in apolipoprotein E-knockout mice in a water maze task

1997 • 142 citations

FROM BIOPHYSICS TO MODELS OF NETWORK FUNCTION

1998 • 140 citations

Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia

1994 • 140 citations

The Role of Synaptic Proteins in the Pathogenesis of Disorders of the Central Nervous System

1993 • 140 citations

Recruitment and replacement of hippocampal neurons in young and adult chickadees: an addition to the theory of hippocampal learning.

1996 • 139 citations

Experience-induced plasticity of cutaneous maps in the primary somatosensory cortex of adult monkeys and rats

1996 • 138 citations

Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders

1993 • 138 citations

Adaptive Mechanisms in Cortical Networks Underlying Cortical Contributions to Learning and Nondeclarative Memory

1990 • 137 citations

Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure

1996 • 137 citations

The pattern of GAP-43 immunostaining changes in the rat hippocampal formation during reactive synaptogenesis

1990 • 137 citations

Presenilin-1 deficiency leads to loss of Cajal–Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

1999 • 136 citations

The cell in contact: Adhesions and junctions as morphogenetic determinants

1986 • 136 citations

Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease

1998 • 135 citations

Head injury as a risk factor in Alzheimer's disease

1995 • 135 citations

Repetitive and Transient Increases in Hippocampal Neural Cell Adhesion Molecule Polysialylation State Following Multitrial Spatial Training

1996 • 134 citations

The development of afferent projections to the robust archistriatal nucleus in male zebra finches: a quantitative electron microscopic study

1991 • 134 citations

Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway

1997 • 133 citations

Sending signals from the synapse to the nucleus: Possible roles for CaMK, Ras/ERK, and SAPK pathways in the regulation of synaptic plasticity and neuronal growth

1999 • 133 citations

The Expression of α-, β-, and γ-Synucleins in Olfactory Mucosa from Patients with and without Neurodegenerative Diseases

1999 • 132 citations

Paired helical filament-like phosphorylation of tau, deposition of β/A4-amyloid and memory impairment in rat induced by chronic inhibition of phosphatase 1 and 2A

1995 • 132 citations

Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target Injury

1999 • 132 citations

Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells.

1997 • 132 citations

Brain Function, Synapse Renewal, and Plasticity

1982 • 131 citations

Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts.

1989 • 131 citations

Experiential modification of the developing brain.

1975 • 131 citations

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion

1992 • 131 citations

Nerve Terminal Remodeling Visualized in Living Mice by Repeated Examination of the Same Neuron

1987 • 130 citations

The protein tyrosine kinase, fyn, in Alzheimerʼs disease pathology

1993 • 130 citations

Expression of the dihydropyrimidinase related protein 2 (DRP-2) in Down Syndrome and Alzheimer’s disease brain is downregulated at the mRNA and dysregulated at the protein level

1999 • 129 citations

The effect of education on dementia occurrence in an Italian population with middle to high socioeconomic status

1998 • 128 citations

Upregulation of Amyloid Precursor Protein Messenger RNA in Response to Traumatic Brain Injury: An Ovine Head Impact Model

1999 • 128 citations

An inhibitor of integrin receptors blocks long-term potentiation

1990 • 128 citations

MAP1B expression and microtubule stability in growing and regenerating axons

2000 • 127 citations

Spatial learning induces neurogenesis in the avian brain

1997 • 127 citations

Rapid anterograde axonal transport of the cellular prion glycoprotein in the peripheral and central nervous systems.

1994 • 126 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

Cortical distribution of neurofibrillary tangles in Alzheimer's disease matches the pattern of neurons that retain their capacity of plastic remodelling in the adult brain

1998 • 126 citations

Quantitative Decrease in Synaptophysin Message Expression and Increase in Cathepsin D Message Expression in Alzheimer Disease Neurons Containing Neurofibrillary Tangles

1999 • 125 citations

Increase in extracellular NCAM and amyloid precursor protein following induction of long-term potentiation in the dentate gyrus of anaesthetized rats

1994 • 125 citations

Apolipoprotein E: A potent inhibitor of endothelial and tumor cell proliferation

1994 • 123 citations

Developmental expression of α-synuclein in rat hippocampus and cerebral cortex

1999 • 121 citations

Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease

1991 • 121 citations

Cell and tissue distribution and developmental change of neuron specific 14 kDa protein (phosphoneuroprotein 14)

1993 • 120 citations

The effect of continuous intraventricular infusion of L1 and NCAM antibodies on spatial learning in rats

1996 • 120 citations

Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses

1992 • 120 citations

Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down Syndrome and Alzheimer's disease

1999 • 120 citations

Chapter 1 Regulation of neuronal nitric oxide synthase and identification of novel nitric oxide signaling pathways

1998 • 119 citations

Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

1995 • 119 citations

Platelet membrane fluidity individuals at risk for Alzheimer's disease: a comparison of results from fluorescence spectroscopy and electron spin resonance spectroscopy

1999 • 118 citations

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.

1991 • 118 citations

Ki-67 Immunoreactivity in Alzheimerʼs Disease and Other Neurodegenerative Disorders

1995 • 118 citations

Differential Regulation of Ciliary Neurotrophic Factor (CNTF) and CNTF Receptor α Expression in Astrocytes and Neurons of the Fascia Dentata after Entorhinal Cortex Lesion

1997 • 117 citations

Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease

1990 • 116 citations

Direct evidence that complex experience increases capillary branching and surface area in visual cortex of young rats

1988 • 116 citations

Synaptic Transmission and Hippocampal Long-Term Potentiation in Transgenic Mice Expressing FAD-Linked Presenilin 1

1999 • 116 citations

NACP, a Synaptic Protein Involved in Alzheimer's Disease, Is Differentially Regulated during Megakaryocyte Differentiation

1997 • 114 citations

Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4.

1996 • 114 citations

Solvent Exposure as a Risk Factor for Alzheimer's Disease: A Case-Control Study

1995 • 113 citations

Dendritic changes in the basal nucleus of meynert and in the diagonal band nucleus in Alzheimer's disease—A quantitative Golgi investigation

1986 • 113 citations

Lipoprotein binding and endosomal itinerary of the low density lipoprotein receptor-related protein in rat liver.

1989 • 112 citations

Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

1990 • 112 citations

Trk receptor alterations in Alzheimer's disease

1996 • 110 citations

Morphoregulation

1992 • 110 citations

Regulation of Secretion of Alzheimer Amyloid Precursor Protein by the Mitogen‐Activated Protein Kinase Cascade

1998 • 109 citations

Axotomy-Induced Apoptotic Cell Death of Neonatal Rat Facial Motoneurons: Time Course Analysis and Relation to NADPH-Diaphorase Activity

1996 • 108 citations

Synaptic plasticity and functional stabilization in the hippocampal formation: possible role in Alzheimer's disease.

1988 • 108 citations

Correlation of cytokine secretion by mononuclear cells of Alzheimer patients and their disease stage

1994 • 107 citations

Protein phosphorylation in neuronal plasticity and gene expression

1995 • 107 citations

N-cadherin expression in developing, adult and denervated chicken neuromuscular system: accumulations at both the neuromuscular junction and the node of Ranvier

1994 • 107 citations

Quantitative Assessment of the Synaptophysin Immuno-Reactivity of the Cortical Neuropil in Various Neurodegenerative Disorderswith Dementia

1993 • 106 citations

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

1990 • 106 citations

Apoptosis-Related Protein Expression in the Hippocampus in Alzheimer’s Disease

1997 • 106 citations

Hippocampal plasticity in Alzheimer's disease: changes in highly polysialylated NCAM immunoreactivity in the hippocampal formation

1999 • 105 citations

Axonal transport of synucleins is mediated by all rate components

1999 • 105 citations

Laminin and its neurite outgrowth‐promoting domain in the brain in Alzheimer's disease and Down's syndrome patients

1992 • 105 citations

Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1993 • 104 citations

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.

1994 • 104 citations

Microtubule-Associated Protein Tau Is Hyperphosphorylated during Mitosis in the Human Neuroblastoma Cell Line SH-SY5Y

1994 • 104 citations

Necessity for Afferent Activity to Maintain Eye-Specific Segregation in Ferret Lateral Geniculate Nucleus

2000 • 104 citations

Immunoreactive Epidermal Growth Factor Receptors in Neuritic Plaques from Patients with Alzheimer's Disease

1988 • 103 citations

Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.

1988 • 103 citations

Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death.

1994 • 103 citations

Stimulation of Immediate Early Gene Expression in Striatal Neurons by Nitric Oxide

1995 • 103 citations

Aberrant expression of nNOS in pyramidal neurons in Alzheimer's disease is highly co-localized with p21ras and p16INK4a

2000 • 102 citations

Purification and Characterization of a Novel Brain‐Specific 14‐kDa Protein

1990 • 102 citations

Cell cycle-dependent phosphorylation and microtubule binding of tau protein stably transfected into Chinese hamster ovary cells.

1995 • 101 citations

Ultrastructural localization of cellular prion protein (PrPc) in synaptic boutons of normal hamster hippocampus.

1995 • 100 citations

Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease

1995 • 100 citations

Focal adhesion kinase expressed by nerve cell lines shows increased tyrosine phosphorylation in response to Alzheimer's A beta peptide.

1994 • 100 citations

Synaptic degeneration is the primary neuropathological feature in prion disease

1993 • 100 citations

Role of amyloid precursor protein (APP): Study with antisense transfection of human neuroblastoma cells

1992 • 99 citations

Mossy fibre reorganization in the hippocampus of prion protein null mice

1997 • 99 citations

Neurobiological bases of spatial learning in the natural environment

1998 • 99 citations

Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease

1990 • 99 citations

Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?

1998 • 98 citations

Activation of a PP2A-like phosphatase and dephosphorylation of τ protein characterize onset of the execution phase of apoptosis

1998 • 98 citations

Synaptic proliferation in the motor cortex of adult cats after long-term thalamic stimulation

1992 • 98 citations

Quantitative Assessment of Synaptic Density in the Outer Molecular Layer of the Hippocampal Dentate Gyrus in Alzheimer's Disease

1996 • 97 citations

Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells

1995 • 96 citations

Cell Surface Amyloid β-Protein Precursor Colocalizes with β1 Integrins at Substrate Contact Sites in Neural Cells

1997 • 95 citations

Cortical plasticity underlying perceptual, motor, and cognitive skill development: implications for neurorehabilitation.

1996 • 95 citations

Cell cycle-related protein expression in vascular dementia and Alzheimer's disease

1999 • 95 citations

Agrin in Alzheimer’s disease: Altered solubility and abnormal distribution within microvasculature and brain parenchyma

1999 • 95 citations

Intraventricular infusions of antibodies to amyloid-β-protein precursor impair the acquisition of a passive avoidance response in the rat

1990 • 94 citations

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

1999 • 94 citations

Education and Occupation as Risk Factors for Dementia: A Population-Based Case-Control Study

1995 • 93 citations

Synaptogenesis of mossy fibers induced by spatial water maze overtraining

1999 • 93 citations

Remodeling of hippocampal synapses after hippocampus-dependent associative learning

2000 • 93 citations

Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease

1994 • 92 citations

Education and Occupation as Risk Factors for Dementias of the Alzheimer and Ischemic Vascular Types

1995 • 92 citations

Increases in dendritic length in occipital cortex after 4 days of differential housing in weanling rats

1992 • 91 citations

Molecular mechanisms that underlie structural and functional changes atthe postsynaptic membrane duringsynaptic plasticity

1998 • 91 citations

Activity-dependent remodeling of connections in the mammalian visual system

1995 • 91 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 91 citations

The brain as a self-organizing system

1986 • 90 citations

Cloning of hippocampal poly(A) RNA sequences that increase after entorhinal cortex lesion in adult rat

1991 • 90 citations

Human Apolipoprotein E Isoform‐Specific Differences in Neuronal Sprouting in Organotypic Hippocampal Culture

1999 • 90 citations

Synapse Loss and Gliosis in the Molecular Layer of the Cerebral Cortex in Alzheimer's Disease and in Frontal Lobe Degeneration

1995 • 90 citations

The Cadherin Superfamily at the Synapse: More Members, More Missions

1998 • 89 citations

The plasticity-pathology continuum: Defining a role for the LTP phenomenon

1999 • 89 citations

Synaptic Density in the Inner Molecular Layer of the Hippocampal Dentate Gyrus in Alzheimer Disease

1998 • 89 citations

Neurotrophic agents may exacerbate the pathologic cascade of Alzheimer's disease

1989 • 89 citations

Secreted Glypican Binds to the Amyloid Precursor Protein of Alzheimer's Disease (APP) and Inhibits APP-induced Neurite Outgrowth

1996 • 89 citations

Localization of amyloid precursor protein in GAP43-immunoreactive aberrant sprouting neurites in Alzheimer's disease

1992 • 88 citations

Neurotrophic and Neuroprotective Effects of hAPP in Transgenic Micea

1996 • 88 citations

Synaptotagmin, a synaptic vesicle protein, is present in human cerebrospinal fluid

1996 • 88 citations

Encephalization in Hominids: Evidence for the Model of Punctuationalism

1983 • 88 citations

The Microtubule-Associated Protein MAP1B Is Involved in Local Stabilization of Turning Growth Cones

2000 • 88 citations

ALTERATIONS IN APOLIPOPROTEIN E EXPRESSION DURING AGING AND NEURODEGENERATION

1996 • 88 citations

Differential Involvement of Synaptic Vesicle and Presynaptic Plasma Membrane Proteins in Alzheimer's Disease

1997 • 87 citations

Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis

1995 • 87 citations

Synaptic Pathology of Alzheimer's Diseasea

1993 • 86 citations

A multivariate statistical summary of synaptic plasticity measures in rats exposed to complex, social and individual environments

1988 • 86 citations

A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease

1990 • 85 citations

Psychiatry and the new dynamics

1994 • 84 citations

Membrane Components Separate Early-Onset Alzheimer's Disease From Senile Dementia of the Alzheimer Type

1996 • 84 citations

Stress and the adaptive self‐organization of neuronal connectivity during early childhood

1998 • 84 citations

The synaptic organization of the neocortex in Alzheimer's disease

1993 • 84 citations

Phosphorylation of Tau, Aβ-Formation, and Apoptosis After In Vivo Inhibition of PP-1 and PP-2A

1998 • 83 citations

Drosophila presenilinIs Required for Neuronal Differentiation and Affects Notch Subcellular Localization and Signaling

1999 • 83 citations

Amyloid precursor protein is localized in growing neurites of neonatal rat brain

1992 • 83 citations

Neuronal alterations in patients with dementia: a Golgi study on biopsy samples

1990 • 83 citations

Chapter 31 Chapter Hippocampal plasticity in normal aging and decreased plasticity in Alzheimer's disease

1990 • 83 citations

Involvement of amyloid precursor protein in functional synapse formation in cultured hippocampal neurons

1998 • 83 citations

The Role of Interleukin-6 in Certain Age-Related Diseases

1994 • 83 citations

Synaptic dysfunction in Alzheimer's disease: clinical assessment using quantitative EEG

1996 • 82 citations

Identification and Immunolocalization of a New Class of Proteoglycan (Keratan Sulfate) to the Neuritic Plaques of Alzheimer's Disease

1996 • 82 citations

Maze training alters brain weights and cortical RNA/DNA ratios

1979 • 81 citations

Cellular Expression and Proteolytic Processing of Presenilin Proteins Is Developmentally Regulated During Neuronal Differentiation

1997 • 81 citations

Individual variation and lateral asymmetry of the rat primary somatosensory cortex

1995 • 81 citations

Alzheimer's disease amyloid precursor protein on the surface of cortical neurons in primary culture co-localizes with adhesion patch components

1996 • 81 citations

A role for a chicken homolog of the neural cell adhesion molecule L1 in consolidation of memory for a passive avoidance task in the chick.

1995 • 81 citations

EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia

1983 • 81 citations

Endogenous FGF-2 Is Important for Cholinergic Sprouting in the Denervated Hippocampus

1997 • 81 citations

Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease

1993 • 80 citations

Effect of Apolipoprotein E on Neurite Outgrowth and β‐Amyloid‐Induced Toxicity in Developing Rat Primary Hippocampal Cultures

1997 • 80 citations

Rapid remodeling of sensory endings in the corneas of living mice

1989 • 79 citations

pH regulation in spread cells and round cells.

1990 • 79 citations

Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes.

1983 • 79 citations

Induction of p21ras in Alzheimer pathology

1995 • 79 citations

β-amyloid-(1–40) increases long-term potentiation in rat hippocampus in vitro

1995 • 78 citations

Pathology and Immunocytochemistry of a Kuru Brain

1997 • 77 citations

Cellular and substrate adhesion molecules (integrins) and their ligands in cerebral amyloid plaques in Alzheimer's disease

1994 • 77 citations

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor

1997 • 76 citations

α-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation

2000 • 74 citations

Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures

1999 • 74 citations

Tau Proteins Are Abnormally Expressed in Olfactory Epithelium of Alzheimer Patients and Developmentally Regulated in Human Fetal Spinal Cord

1993 • 74 citations

Structural and Functional Analysis of a Mutant Ras Protein That Is Insensitive to Nitric Oxide Activation

1997 • 74 citations

Identification and distribution of axonal dystrophic neurites in Alzheimer's disease

1993 • 74 citations

Enhanced Synaptic Potentiation in Transgenic Mice Expressing presenilin 1 Familial Alzheimer's Disease Mutation Is Normalized with a Benzodiazepine

2000 • 73 citations

Alzheimer Amyloid Protein Precursor Enhances Proliferation of Neural Stem Cells from Fetal Rat Brain

1994 • 73 citations

Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia

1998 • 73 citations

Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice

1999 • 73 citations

Transient and persistent increases in protein phosphatase activity during long-term depression in the adult hippocampus in vivo

1998 • 73 citations

Embryonic neural cell adhesion molecule (N-CAM) is elevated in the denervated rat dentate gyrus

1994 • 73 citations

Density of somatic innervation on mammalian autonomic ganglion cells is inversely related to dendritic complexity and preganglionic convergence

1985 • 73 citations

Differential metabolic and electrical activity in the somatic sensory cortex of juvenile and adult rats

1993 • 72 citations

Selective localization of amyloid precursor-like protein 1 in the cerebral cortex postsynaptic density

1995 • 72 citations

Activated Mitogenic Signaling Induces a Process of Dedifferentiation in Alzheimer's Disease That Eventually Results in Cell Death

2000 • 71 citations

Neocortical Synapse Density and Braak Stage in the Lewy Body Variant of Alzheimer Disease: A Comparison with Classic Alzheimer Disease and Normal Aging

1998 • 71 citations

Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons

1992 • 70 citations

Expression of a phosphorylated isoform of MAP1B is maintained in adult central nervous system areas that retain capacity for structural plasticity

1996 • 69 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 69 citations

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons

1999 • 69 citations

Altered synaptic plasticity in hippocampal CA1 area of apolipoprotein E deficient mice

1997 • 69 citations

Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. III. The basal forebrain compared with other subcortical areas

1995 • 69 citations

Telencephalon-specific antigen identified by monoclonal antibody.

1987 • 69 citations

Hepatocyte growth factor (HGF/SF) in Alzheimer's disease

1998 • 69 citations

Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients

1994 • 68 citations

Developmental Regulation of Presenilin mRNA Expression Parallels Notch Expression

1997 • 68 citations

Dynamics of synapsin I gene expression during the establishment and restoration of functional synapses in the rat hippocampus

1994 • 67 citations

In vivo PET imaging and postmortem studies suggest potentially reversible and irreversible stages of brain metabolic failure in Alzheimer’s disease

1999 • 67 citations

Developmental Regulation of Presenilin-1 Processing in the Brain Suggests a Role in Neuronal Differentiation

1997 • 67 citations

Apolipoprotein E and the Response of the Brain to Injury

1999 • 67 citations

Behaviorally Based Modeling and Computational Approaches to Neuroscience

1993 • 66 citations

Dendritic Translocation of RC3/Neurogranin mRNA in Normal Aging, Alzheimer Disease and Fronto-Temporal Dementia

1997 • 65 citations

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

1999 • 65 citations

Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia

1984 • 65 citations

Changes in nerve growth factor immunoreactivity following entorhinal cortex lesions: Possible molecular mechanism regulating cholinergic sprouting

1994 • 65 citations

Cholinergic Neurons of the Nucleus basalis Express Elevated Levels of Nerve Growth Factor Receptor mRNA in Senile Dementia of the Alzheimer Type

1990 • 65 citations

Deterioration threshold of synaptic morphology in aging and senile dementia of Alzheimer's type.

1996 • 65 citations

Models of activity-dependent neural development

1994 • 64 citations

Synthesis and transport of GAP-43 in entorhinal cortex neurons and perforant pathway during lesion-induced sprouting and reactive synaptogenesis

1992 • 64 citations

The Cell in contact : adhesions and junctions as morphogenetic determinants

1985 • 64 citations

Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells

1998 • 64 citations

Bax and Bak proteins require caspase activity to trigger apoptosis in sympathetic neurons

1998 • 64 citations

Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons

1994 • 63 citations

Protection against developmental retardation in apolipoprotein E-deficient mice by a fatty neuropeptide: Implications for early treatment of Alzheimer's disease

1997 • 63 citations

Increased immunoreactivity of brain spectrin in Alzheimer disease: a marker for synapse loss?

1990 • 63 citations

Interaction of beta-amyloid peptides with integrins in a human nerve cell line

1995 • 63 citations

Regulation of neuronal plasticity in the central nervous system by phosphorylation and dephosphorylation

1998 • 63 citations

Alzheimer's Disease Neurofibrillary Tangles Contain Mitosis‐Specific Phosphoepitopes

1996 • 63 citations

An immunocytochemical and biochemical study of the microtubule-associated protein MAP-2 during post-lesion dendritic remodeling in the central nervous system of adult rats

1988 • 63 citations

pp125FAK in the Focal Adhesion

1996 • 62 citations

Neurotrophic factor mRNA expression in dentate gyrus is increased following in vivo stimulation of the angular bundle

1994 • 62 citations

Insulin-like growth factor-I (IGF-I) immunoreactivity in the Alzheimer's disease temporal cortex and hippocampus

1997 • 62 citations

Synaptic β-amyloid precursor proteins increase with learning capacity in rats

1997 • 62 citations

Entorhinal lesions result in increased nerved growth factor-like growth-promoting activity in medium conditioned by hippocampal slices

1986 • 62 citations

Neuron/glia relationships observed over intervals of several months in living mice.

1988 • 62 citations

Characterization of the high affinity heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP) and its enhancement by zinc(II)

1995 • 62 citations

Emergent properties of neural systems: How focal molecular neurobiological alterations can affect behavior

1997 • 61 citations

MAP kinase does not inactivate, but rather prevents the cyclin degradation pathway from being turned on in Xenopus egg extracts

1996 • 61 citations

Degenerative terminals of the perforant pathway are human α-synuclein-immunoreactive in the hippocampus of patients with diffuse Lewy body disease

1998 • 61 citations

The hippocampus and its response to differential environments

1980 • 60 citations

Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions

1992 • 60 citations

N‐Cadherin Is a Major Glycoprotein Component of Isolated Rat Forebrain Postsynaptic Densities

1995 • 59 citations

Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAF1/CIP1.

1998 • 59 citations

Increased expression of the embryonic form of a developmentally regulated mRNA in Alzheimer's disease

1990 • 59 citations

Interaction of Apolipoprotein E with Laminin Increases Neuronal Adhesion and Alters Neurite Morphology

1995 • 59 citations

Hyperactivation of Signal Transduction Systems in Alzheimer's Diseasea

1993 • 59 citations

Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A/G1B boundary

1995 • 59 citations

Entorhinal cortex lesion induces differential responses in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in the rat hippocampal formation

1993 • 59 citations

Differing patterns of aberrant neuronal sprouting in Alzheimer's disease with and without Lewy bodies

1993 • 58 citations

APPL, the Drosophila member of the APP-family, exhibits differential trafficking and processing in CNS neurons.

1996 • 58 citations

On the origin of Alzheimerʼs disease

1993 • 58 citations

Proteolytic Fragments of Alzheimer’s Disease‐Associated Presenilin 1 Are Present in Synaptic Organelles and Growth Cone Membranes of Rat Brain

1999 • 58 citations

Prion protein is necessary for latent learning and long-term memory retention.

1997 • 58 citations

Temporal Cortex Synaptophysin mRNA Is Reduced in Alzheimer's Disease and Is Negatively Correlated with the Severity of Dementia

1998 • 57 citations

Growth-regulated proteins and neuronal plasticity

1991 • 56 citations

Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus

1994 • 56 citations

Aberrancies in signal transduction and cell cycle related events in Alzheimer’s disease

1998 • 56 citations

Cross‐linking of β‐amyloid protein precursor catalysed by tissue transglutaminase

1994 • 56 citations

Plasticity in auditory cortical circuitry

1994 • 56 citations

Selective alterations of RNA in rat hippocampus after entorhinal cortex lesioning.

1990 • 56 citations

Increased Apolipoprotein E mRNA in the Hippocampus in Alzheimer Disease and in Rats after Entorhinal Cortex Lesioning

1998 • 55 citations

A chicken monoclonal antibody with specificity for the N-terminal of human prion protein

1999 • 55 citations

Inhibitors of cyclin-dependent kinase and cancer

1995 • 55 citations

Synaptic Plasticity in the CA1 Area of the Hippocampus of Scrapie-Infected Mice

1998 • 55 citations

Immunohistochemical distribution of amyloid precursor protein during normal rat development

1993 • 55 citations

Neural activity and the growth of the brain

1995 • 55 citations

Neuronal-Based Synaptic Compensation: A Computational Study in Alzheimer's Disease

1996 • 55 citations

Reduction of Neurological Damage by a Peptide Segment of the Amyloid β/A4 Protein Precursor in a Rabbit Spinal Cord Ischemia Model

1994 • 54 citations

Structural plasticity at identified synapses during long‐term memory in Aplysia

1989 • 54 citations

Down-regulation of the amyloid protein precursor of Alzheimer's disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata

1997 • 54 citations

Amyloid deposition in the nucleus basalis of Meynert complex: a topographic marker for degenerating cell clusters in Alzheimer's disease

1988 • 53 citations

Developmental and differential expression of beta amyloid protein precursor mRNAs in mouse brain

1990 • 53 citations

The septo-hippocampal pathway in patients suffering from senile dementia of Alzheimer's type. Evidence for neuronal plasticity?

1987 • 53 citations

Substrate‐Bound β‐Amyloid Peptides Inhibit Cell Adhesion and Neurite Outgrowth in Primary Neuronal Cultures

2000 • 53 citations

Nerve Growth Factor and Ras Regulate β‐Amyloid Precursor Protein Gene Expression in PC12 Cells

1996 • 53 citations

Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases

1992 • 52 citations

FAC1, a Novel Gene Identified with the Monoclonal Antibody Alz50, Is Developmentally Regulated in Human Brain

1995 • 52 citations

Monoclonal Antibody to Embryonic CNS Antigen A2B5 Provides Evidence for the Involvement of Membrane Components at Sites of Alzheimer Degeneration and Detects Sulfatides as Well as Gangliosides

1989 • 52 citations

Perlecan Mediates the Antiproliferative Effect of Apolipoprotein E on Smooth Muscle Cells

1999 • 51 citations

Apolipoprotein E and Low‐Density Lipoprotein Binding and Internalization in Primary Cultures of Rat Astrocytes: Isoform‐Specific Alterations

1996 • 51 citations

Mutation in the prion protein gene at codon 232 in Japanese patients with Creutzfeldt-Jakob disease: a clinicopathological, immunohistochemical and transmission study

1996 • 51 citations

Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment

1996 • 51 citations

Specific Neurochemical Derangements of Brain Projecting Neurons in Apolipoprotein E‐Deficient Mice

1998 • 51 citations

The synaptic protein NACP is abnormally expressed during the progression of Alzheimer' s disease

1996 • 51 citations

Transient upregulation of NCAM mRNA in astrocytes in response to entorhinal cortex lesions and ischemia

1995 • 50 citations

Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system

1995 • 50 citations

Effects of increased neural activity on brain growth.

1995 • 49 citations

The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not actively motile portions of neurites

1996 • 49 citations

Prenatal Development of NADPH-diaphorase-Reactive Neurons in Human Frontal Cortex

1996 • 49 citations

APP-collagen interaction is mediated by a heparin bridge mechanism

1992 • 49 citations

Synaptic loss reflected by secretoneurin‐like immunoreactivity in the human hippocampus in Alzheimer's disease

1998 • 49 citations

Increased number and size of dendritic spines in ipsilateral barrel field cortex following unilateral whisker trimming in postnatal rat

1998 • 48 citations

Modifiable neuronal connections: an overview for psychiatrists

1997 • 48 citations

Changes in synaptic expression of clathrin assembly protein AP180 in Alzheimer's disease analysed by immunohistochemistry

1999 • 48 citations

Dystrophic Neurites of Senile Plaques are Defective in Proteins Involved in Exocytosis and Neurotransmission

1998 • 48 citations

Phosphorylated Tau Epitope of Alzheimer's Disease Is Coupled to Axon Development in the Avian Central Nervous System

1993 • 48 citations

Growth of abnormal neurites in atypical Alzheimer's disease

1983 • 47 citations

The binding of basic fibroblast growth factor to Alzheimer's neurofibrillary tangles and senile plaques

1991 • 47 citations

Expression of Proteins Linked to Exocytosis and Neurotransmission in Patients with Creutzfeldt–Jakob Disease

1999 • 47 citations

Chapter 30 Axon sprouting in the rodent and Alzheimer's disease brain: a reactivation of developmental mechanisms?

1990 • 47 citations

A synthetic peptide mimic of plasma apolipoprotein E that binds the LDL receptor.

1991 • 47 citations

APPL, theDrosophilaMember of the APP-Family, Exhibits Differential Trafficking and Processing in CNS Neurons

1996 • 46 citations

Localization of Alzheimer-Associated Presenilin 1 in Transfected COS-7 Cells

1996 • 46 citations

PDGF is associated with neuronal and glial alterations of Alzheimer's disease

1995 • 46 citations

Alternate strategies in lesion-induced reactive synaptogenesis: differetial expression of L1 in two populations of sprouting axons

1995 • 45 citations

Dendritic degeneration and regrowth in the cerebral cortex of patients with Alzheimer's disease

1980 • 45 citations

Mechanisms of synaptic pathology in Alzheimer’s disease

1998 • 45 citations

Signaling events regulating the neurodevelopmental triad. Glutamate and secreted forms of beta-amyloid precursor protein as examples.

1998 • 45 citations

Altered long-term potentiation in the hippocampus of apolipoprotein E-deficient mice

1998 • 44 citations

Neurotransmitters, peptides, and neural cell adhesion molecules in the cortices of normal elderly humans and alzheimer patients: a comparison

1999 • 44 citations

Neuritic sprouting with aberrant expression of the nitric oxide synthase III gene in neurodegenerative diseases

1999 • 43 citations

Appican Expression Induces Morphological Changes in C6 Glioma Cells and Promotes Adhesion of Neural Cells to the Extracellular Matrix

1997 • 43 citations

Degeneration and regeneration of autonomic nerve endings in the anterior part of rhesus monkey ciliary muscle

1978 • 43 citations

Synaptophysin Immunoreactivity of the Cortical Neuropil in Vascular Dementia of Binswanger Type Compared with the Dementia of Alzheimer Type and Nondemented Controls

1994 • 43 citations

Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation

1997 • 43 citations

BDNF and trkB mRNA expression in the rat hippocampus following entorhinal cortex lesions

1993 • 42 citations

Cellular Pathology in Alzheimer’s Disease: Implications for Corticocortical Disconnection and Differential Vulnerability

1990 • 42 citations

Development of glomerular pattern visualized in the olfactory bulbs of living mice

1989 • 42 citations

Neural differentiation increases expression of Alzheimer amyloid protein precursor gene in murine embryonal carcinoma cells

1990 • 42 citations

HB-GAM is a cytokine present in Alzheimerʼs and Downʼs syndrome lesions

1996 • 42 citations

Characterization of Appican, the Chondroitin Sulfate Proteoglycan Form of the Alzheimer Amyloid Precursor Protein

1996 • 42 citations

Expression of the neural adhesion molecule L1 in the deafferented dentate gyrus

1996 • 42 citations

Increased immunogold labelling of neural cell adhesion molecule isoforms in synaptic active zones of the chick striatum 5–6 hours after one-trial passive avoidance training

1997 • 42 citations

Increased Expression of β‐Amyloid Protein Precursor and Microtubule‐Associated Protein τ During the Differentiation of Murine Embryonal Carcinoma Cells

1992 • 42 citations

Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. I. Dendritic organisation of the normal human basal forebrain

1995 • 41 citations

A computational model of the progression of Alzheimer's disease.

1997 • 41 citations

Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls

1996 • 41 citations

Neuronal maturation and synaptogenesis in the rat ventrobasal complex: Alignment with developmental changes in rate and severity of axon reaction

1977 • 41 citations

Novel Domain-Specific Actions of Amyloid Precursor Protein on Developing Synapses

1998 • 41 citations

Theoretical aspects of neuroplasticity.

1999 • 40 citations

Regenerative Failure: A Potential Mechanism for Neuritic Dystrophy in Alzheimer's Disease

1996 • 40 citations

Amyloid precursor protein is enriched in radial glia: Implications for neuronal development

1994 • 39 citations

Alzheimer's beta-amyloid precursor protein is expressed on the surface of immediately ex vivo brain cells: A flow cytometric study

1996 • 39 citations

Structural characterization of the tumor suppressor p16, an ankyrin‐like repeat protein

1996 • 39 citations

Ultrastructural localization of cellular prion protein (PrPc) at the neuromuscular junction

1999 • 39 citations

Nonclassical Roles of Cholinesterases in the Embryonic Brain and Possible Links to Alzheimer Disease

1995 • 39 citations

Neuro-regeneration: plasticity for repair and adaptation

1998 • 39 citations

Rapid expression and transport of embryonic N‐CAM in dentate gyrus following entorhinal cortex lesion: Ultrastructural analysis

1994 • 38 citations

SCG 10, A neuron-specific growth-associated protein in Alzheimer's disease

1995 • 38 citations

The process of reinnervation in the dentate gyrus of adult rats: Gene expression by neurons during the period of lesion‐induced growth

1995 • 38 citations

Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5

1991 • 37 citations

Aβ peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line

1996 • 37 citations

Differential synaptic loss in the cortex in Alzheimerʼs disease: a study using archival material

1994 • 37 citations

Increase of c-fos and ras oncoproteins in the denervated neuropil of the rat dentate gyrus

1994 • 37 citations

Epidermal growth factor receptor expression in demented and aged human brain

1990 • 36 citations

Intrinsic Physiological and Morphological Properties of Principal Cells of the Hippocampus and Neocortex in Hamsters Infected with Scrapie

1999 • 36 citations

Synelfin Regulation during the Critical Period for Song Learning in Normal and Isolated Juvenile Zebra Finches

1997 • 35 citations

Amyloid Precursor-like Protein 2 Promotes Cell Migration toward Fibronectin and Collagen IV

1999 • 35 citations

Computer-Assisted Morphometry of Synaptic Plasticity during Aging and Dementia

1989 • 35 citations

Accumulation of SNAP-25 immunoreactive material in axons of Alzheimerʼs disease

1997 • 35 citations

Expression of Presenilin 1 in nervous system during rat development

1999 • 35 citations

Histologische und histopathologische Arbeiten über die Grosshirnrinde : mit besonderer Berücksichtigung der pathologischen Anatomie der Geisteskrankheiten

1904 • 35 citations

Increases in mRNA for cytoskeletal proteins in the denervated neuropil of the dentate gyrus: an in situ hybridization study using riboprobes for β-actin and β-tubulin

1990 • 34 citations

Involvement of the spinal posterior horn in Gerstmann–Sträussler–Scheinker disease (PrP P102L)

1999 • 34 citations

Alzheimer's Disease: Does Neuron Plasticity Predispose to Axonal Neurofibrillary Degeneration?

1985 • 33 citations

Alzheimer's Disease: Maladaptive Synaptoplasticity Hypothesis

1995 • 33 citations

Abnormal brain spectrin immunoreactivity in sprouting neurons in Alzheimer disease

1991 • 33 citations

Submicroscopic immunodetection of PrP in the brain of a patient with a new-variant of Creutzfeldt–Jakob disease

1999 • 32 citations

Effects of apolipoprotein E genotype on blood lipid composition and membrane platelet fluidity in Alzheimer’s disease

1999 • 32 citations

Perisomatic sprouts immunoreactive for nerve growth factor receptor and neurofibrillary degeneration affect different neuronal populations in the basal nucleus in patients with Alzheimer's disease

1992 • 32 citations

Inhibition of neurite outgrowth by familial Alzheimer's disease-linked presenilin-1 mutations

1999 • 32 citations

Neurotrophic factor mRNA expression in dentate gyrus is increased following angular bundle transection

1994 • 31 citations

Fetal Alz-50 Clone 1, a Novel Zinc Finger Protein, Binds a Specific DNA Sequence and Acts as a Transcriptional Regulator

1999 • 31 citations

Synaptotagmin and synaptic transmission alterations in apolipoprotein E-deficient mice

1999 • 31 citations

Alzheimer's disease and down syndrome: leukocyte membrane fluidity alterations

1994 • 30 citations

Increase in Syntaxin 1B mRNA in Hippocampal and Cortical Circuits During Spatial Learning Reflects a Mechanism of Trans-synaptic Plasticity Involved in Establishing a Memory Trace

1998 • 30 citations

Ras‐Signaling Pathways: Positive and Negative Regulation of Tau Expression in PC12 Cells

1998 • 30 citations

Immunoreactivity of the nuclear antigen p105 is associated with plaques and tangles in Alzheimer's disease.

1993 • 30 citations

Amyloid precursor protein is enriched in axolemma and periaxolemmal‐myelin and associated clathrin‐coated vesicles

1994 • 30 citations

The role of β-catenin stability in mutant PS1-associated apoptosis

1999 • 29 citations

Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain.

1996 • 29 citations

Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses

1996 • 29 citations

Embryonic genes expressed in Alzheimer's disease brains

1996 • 28 citations

Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations

1998 • 28 citations

An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats

1987 • 28 citations

Inhibition of lymphocyte proliferation by synthetic peptides homologous to human plasma apolipoproteins B and E

1988 • 28 citations

APP+ T lymphocytes selectively sorted to endomysial tubes in polymyositis displace NCAM-expressing muscle fibers.

1993 • 28 citations

Oncogenesis and altered differentiation induced by activated Ras in neuroblasts of transgenic mice

1997 • 28 citations

Is brain plasticity preserved during aging and in Alzheimer's disease?

1996 • 28 citations

Is Chronic Low-Level Lead Exposure in Early Life an Etiologic Factor in Alzheimer’s Disease?

1998 • 28 citations

Modulation of neuronal thread protein expression with neuritic sprouting: relevance to Alzheimer's disease

1996 • 27 citations

Distribution of PNP 14 (β-synuclein) in neuroendocrine tissues: Localization in Sertoli cells

1998 • 27 citations

Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein

1994 • 26 citations

A Quantitative and Immunohistochemical Study on Apolipoprotein E in Brain Tissue in Alzheimer’s Disease

1999 • 26 citations

[Premorbid psychological processes in patients with Alzheimer's disease and in patients with vascular dementia].

1995 • 26 citations

Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly

1995 • 25 citations

Expression of vimentin increases in the hippocampus and cerebral cortex after entorhinal cortex lesioning and in response to transforming growth factor β 1

1995 • 25 citations

Structural plasticity of synapses in Alzheimer's disease

1991 • 24 citations

Neural activity and the development of the somatic sensory system

1994 • 24 citations

Sprouting and abnormal contacts of nonmedullated axons, and deposition of extracellular material induced by the amyloid precursor protein (APP) and other protease inhibitors

1996 • 24 citations

Molecular Markers of Reactive Plasticity

1990 • 24 citations

Thy-1 is critical for normal retinal development

1999 • 24 citations

Brefeldin A-induced apoptosis is expressed in rat neurons with dephosphorylated tau protein

1998 • 24 citations

Neuronal apoptosis is associated with a decrease in tau mRNA expression

1998 • 24 citations

Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease

1997 • 24 citations

Neuroplasticity, the aging brain, and Alzheimer's disease.

1992 • 24 citations

Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.

1996 • 23 citations

Effects of monocular deprivation on the morphology of retinogeniculate axon arbors in a primate

1990 • 23 citations

Cholinergic sprouting in the rat fascia dentata after entorhinal lesion is not linked to early changes in neurotrophin messenger RNA expression

1997 • 23 citations

Prospective Study of Risk Factors for Alzheimer’s Disease: Results at 7.5 Years

1999 • 23 citations

M‐cadherin Distribution in the Mouse Adult Neuromuscular System Suggests a Role in Muscle Innervation

1996 • 23 citations

Training in chicks alters PSA-N-CAM distribution in forebrain cell membranes

1994 • 23 citations

Chapter 1 Neural plasticity in aging and Alzheimer's disease: some selected comments

1990 • 22 citations

Cortical load of PHF-tau in Alzheimer's disease is correlated to cholinergic dysfunction

1999 • 22 citations

Monogenic determinants of familial Alzheimer's disease: presenilin-2 mutations

1998 • 22 citations

Self-organization: The basic principle of neural functions

1993 • 22 citations

Alzheimer's disease as a presumptive threshold phenomenon

1987 • 21 citations

Aberrant localization of MAP5 immunoreactivity in the hippocampal formation in alzheimer's disease

1991 • 21 citations

β-Amyloid precursor protein-like immunoreactivity is upregulated during olfactory nerve regeneration in adult rats

1998 • 20 citations

Hemisynaptic distribution patterns of presenilins and ?-APP isoforms in the rodent cerebellum and hippocampus

2000 • 20 citations

The neurofilament antibody RT97 recognises a developmentally regulated phosphorylation epitope on microtubule‐associated protein 1B

1997 • 20 citations

Nitric oxide and Alzheimer's disease.

1998 • 20 citations

Amyloid Precursor Protein Fragment and Acetylcholinesterase Increase with Cell Confluence and Differentiation in a Neuronal Cell Line

1996 • 20 citations

In Vivo Neuronal Synthesis and Axonal Transport of Kunitz Protease Inhibitor (KPI)‐Containing Forms of the Amyloid Precursor Protein

1994 • 19 citations

The Echigo-1: a panencephalopathic strain of Creutzfeldt-Jakob disease: a passage to hamsters and ultrastructural studies.

1997 • 18 citations

Identification of Amyloid Precursor Protein in Synaptic Plasma Membrane

1993 • 18 citations

Ras P21 protein promotes survival and differentiation of human embryonic neural crest-derived cells

1996 • 18 citations

Altered phosphorylation of growth-associated protein B50/GAP-43 in Alzheimer disease with high neurofibrillary tangle density.

1993 • 18 citations

Characterization of thread proteins expressed in neuroectodermal tumors.

1993 • 17 citations

Antibodies to human brain spectrin in Alzheimer's disease

1996 • 17 citations

Nitric oxide donors enhance neurotrophin‐induced neurite outgrowth through a cGMP‐dependent mechanism

1997 • 16 citations

Inhibition of long-term potentiation development in rat hippocampal slice by ?2-macroglobulin, an acute-phase protein in the brain

1996 • 16 citations

Apolipoprotein E Antibodies Affect the Retention of Passive Avoidance Memory in the Chick

1998 • 16 citations

Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat

2000 • 16 citations

Age-dependent deterioration of neuronal mambranes and the pathogenesis of Alzheimer's disease: A hypothesis

1988 • 16 citations

Modulation of γ-actin and α1-tubulin expression by corticosterone during neuronal plasticity in the hippocampus

1992 • 16 citations

Expression of β-amyloid precursor protein in the developing human spinal cord

1994 • 15 citations

Phosphorylation of microtubule-associated protein tau on Ser 262 by an embryonic 100 kDa protein kinase

1997 • 15 citations

Neuroscience, Modularity and Personality Theory: Conceptual Foundations of a Model of Complex Human Functioning

1991 • 14 citations

Observations on the evolution of the cholinergic system in the telencephalon of vertebrates

1982 • 14 citations

Maintenance of Neuronal Plasticity in the Reticular Core and Changes in Trophic Activity in Alzheimer's Disease

1991 • 14 citations

Aberrant plasticity in Alzheimerʼs disease

1999 • 14 citations

A possible fetal antigen ofMr70,000 in neurofibrillary tangles

1991 • 13 citations

Giant nerve fibers in the ciliary muscle and iris sphincter of Macaca mulatta

1976 • 13 citations

Compensatory enlargement of synaptic size in aging and senile dementia.

1993 • 12 citations

Changes in a Protein-Nucleic Acid Complex from Synaptic Plasma Membrane of Scrapie-Infected Mouse Brain

1976 • 10 citations

Presenilin-1 mRNA andß-amyloid Precursor Protein mRNA are Expressed in the Developing Rat Olfactory and Vestibulocochlear Systems

1998 • 10 citations

Cytoskeletal alterations might account for the phylogenetic vulnerability of the human brain to Alzheimer's disease

1991 • 10 citations

Thy-1 in Hippocampus

1992 • 10 citations

Regional distribution of presenilin-1 messenger RNA in the embryonic rat brain: comparison with β-amyloid precursor protein messenger RNA localization

1999 • 10 citations

ASSESSING SOME DYNAMIC PROPERTIES OF THE LIVING NERVOUS SYSTEM

1989 • 10 citations

Immunhistological evaluation of Creutzfeldt-Jakob disease with reference to the type PrPres deposition.

1996 • 9 citations

Brain Plasticity, Learning and Memory: Historical Background and Conceptual Perspectives

1985 • 9 citations

The Neuritic Dystrophy of Alzheimer’s Disease: Degeneration or Regeneration?

1991 • 9 citations

Interaction foci, information synthesis, and mental activity

1994 • 9 citations

Mitotic index and Alzheimerʼs disease

1998 • 7 citations

CEREBRAL ORGANIZATION AND THE INTEGRATION OF EXPERIENCE

1972 • 7 citations

Brain self-organization dynamics.

1993 • 7 citations

Postnatal development of NADPH-diaphorase positive nerve cells in the visual cortex of the rat

1995 • 5 citations

Synaptic Aspects of the Cellular Prion Protein

1997 • 4 citations

Is Alzheimer's disease associated with reexpression of a developmental protein pattern?

1992 • 4 citations

Study of early stages of the pathogenesis of scrapie in experimentally infected mice.

1983 • 3 citations

Deleted Work

1955 • 0 citations