Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Observations on the brains of demented old people

1970 • 2,066 citations

Microtubule Assembly in the Absence of Added Nucleotides

1973 • 2,055 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Microtubule-associated protein tau. A component of Alzheimer paired helical filaments.

1986 • 1,709 citations

Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

1986 • 1,387 citations

Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology

1986 • 944 citations

Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease.

1988 • 920 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease

1987 • 834 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease

1991 • 801 citations

Accumulation of abnormally phosphorylated τ precedes the formation of neurofibrillary tangles in Alzheimer's disease

1989 • 783 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

Plaques, tangles and dementia

1982 • 603 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Phosphoprotein Phosphatase Activities in Alzheimer Disease Brain

1993 • 504 citations

Phosphorylated Tau Protein Is Integrated into Paired Helical Filaments in Alzheimer's Disease1

1986 • 504 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

1986 • 419 citations

Neuritic pathology and dementia in alzheimer's disease

1991 • 362 citations

Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease

1987 • 348 citations

Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS

1989 • 241 citations

Patterns of aberrant sprouting in alzheimer's disease

1991 • 241 citations

Subunit structure of paired helical filaments in Alzheimer's disease.

1985 • 224 citations

Difference between the tau protein of Alzheimer paired helical filament core and normal tau revealed by epitope analysis of monoclonal antibodies 423 and 7.51.

1991 • 214 citations

MAP5: A novel brain microtubule-associated protein under strong developmental regulation

1986 • 210 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Microtubule-associated protein 1B: Molecular structure, localization, and phosphorylation-dependent expression in developing neurons

1989 • 185 citations

Three-Dimensional Analysis of the Relationship Between Synaptic Pathology and Neuropil Threads in Alzheimer Disease

1992 • 180 citations

The adult rat olfactory system expresses microtubule-associated proteins found in the developing brain

1989 • 172 citations

In situ localization of microtubule-associated protein mRNA in the developing and adult rat brain

1989 • 165 citations

Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells.

1993 • 160 citations

A casein kinase II-related activity is involved in phosphorylation of microtubule-associated protein MAP-1B during neuroblastoma cell differentiation.

1988 • 153 citations

Microtubule assembly in the absence of added nucleotides

1973 • 147 citations

Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type

1989 • 136 citations

Characterization of brain microtubule proteins prepared by selective removal of mitochondrial and synaptosomal components.

1979 • 116 citations

Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease

1990 • 106 citations

Heterogeneity in the Phosphorylation of Micro tubule‐Associated Protein MAP 1B During Rat Brair Development

1993 • 89 citations

The distribution and phosphorylation of the microtubule-associated protein MAP 1B in growth cones

1991 • 88 citations

Downregulation of CDC2 upon terminal differentiation of neurons.

1991 • 86 citations

Difference in distribution of microtubule-associated proteins 5a and 5b during the development of cerebral cortex and corpus callosum in cats: dependence on phosphorylation

1990 • 76 citations

Dephosphorylation of distinct sites on microtubule‐associated protein MAP1B by protein phosphatases 1, 2A and 2B

1993 • 48 citations

Evidence that transmitter‐containing dystrophic neurites precede paired helical filament and Alz‐50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease

1993 • 46 citations

Immunohistological study on brains of Alzheimer's disease using antibodies to fetal antigens, C-series gangliosides and microtubule-associated protein 5

1991 • 37 citations

Association of microtubule-associated protein (MAP1B) with growing axons in cultured hippocampal neurons

1991 • 36 citations

High molecular weight microtubule-associated proteins bind to actin lattices (Hirano bodies)

1988 • 34 citations

An immunocytochemical and biochemical study of the microtubule-associated protein Tau during post-lesion afferent reorganization in the hippocampus of adult rats

1987 • 28 citations

Dystrophic peptidergic neurites in senile plaques of Alzheimer's disease hippocampus precede formation of paired helical filaments

1989 • 27 citations

Quantitation and characterization of tau factor in porcine tissues

1986 • 24 citations

Phosphorylated MAP1b, alias MAP5 and MAP1x, is involved in axonal growth and neuronal mitosis

1993 • 22 citations

Proline-directed kinase systems in Alzheimer's disease pathology

1993 • 20 citations

Altered levels of microtubule proteins in brains of Alzheimer's disease patients

1989 • 18 citations

Cholinesterase histochemistry in the human brain: effect of various fixation and storage conditions

1992 • 14 citations

Solubilization and fractionation of paired helical filaments

1992 • 14 citations

A possible fetal antigen ofMr70,000 in neurofibrillary tangles

1991 • 13 citations

Collagenous structures present in brain contain epitopes shared by collagen and microtubule-associated protein tau

1990 • 7 citations

THE ABNORMAL PHOSPHORYLATION OF TAU AT SER396 IN ALZHEIMERʼS DISEASE RECAPITULATES PHOSPHORYLATION DURING DEVELOPMENT AND CONTRIBUTES TO REDUCED MICROTUBULE BINDING

1993 • 6 citations