Apoptosis-Related Protein Expression in the Hippocampus in Alzheimer’s Disease

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease

1994 • 1,213 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

The NINCDS‐ADRDA Work Group criteria for the clinical diagnosis of probable Alzheimer's disease

1988 • 611 citations

The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

1993 • 586 citations

Immunohistochemical evidence for apoptosis in Alzheimerʼs disease

1994 • 569 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

Evidence for Apoptotic Cell Death in Alzheimer's Disease

1995 • 482 citations

Upregulation of bax protein levels in neurons following cerebral ischemia

1995 • 440 citations

Expression of bcl-xL can confer a multidrug resistance phenotype

1995 • 421 citations

Dicing with death: dissecting the components of the apoptosis machinery

1994 • 363 citations

BCL-2: Prevention of Apoptosis as a Mechanism of Drug Resistance

1995 • 323 citations

Relative Roles of Plaques and Tangles in the Dementia of Alzheimer's Disease: Correlations Using Three Sets of Neuropathological Criteria

1995 • 281 citations

Downregulation of Cu/Zn superoxide dismutase leads to cell death via the nitric oxide-peroxynitrite pathway

1996 • 267 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Expression of the Apoptosis‐Effector Gene, Bax, Is Up‐Regulated in Vulnerable Hippocampal CA1 Neurons Following Global Ischemia

1996 • 238 citations

DNA End Labeling (TUNEL) in Huntington's Disease and Other Neuropathological Conditions

1995 • 221 citations

Bcl-xS Antagonizes the Protective Effects of Bcl-xL

1996 • 200 citations

Bcl‐2 proto‐oncogene expression in epstein‐barr‐virus‐associated nasopharyngeal carcinoma

1993 • 198 citations

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.

1994 • 182 citations

Bcl-2 and Bcl-x: regulatory switches for lymphoid death and survival

1994 • 164 citations

Apoptosis and cancer: the failure of controls on cell death and cell survival

1995 • 158 citations

Apoptosis induced by erythroid differentiation of human leukemia cell lines is inhibited by Bcl-XL

1996 • 138 citations

Differential Induction of Immediate Early Gene Proteins in Cultured Neurons by β‐Amyloid (Aβ): Association of c‐Jun with Aβ‐Induced Apoptosis

1995 • 136 citations

Immunoreactivity for Bcl-2 protein within neurons in the Alzheimer's disease brain increases with disease severity

1995 • 130 citations

Bcl-2 affects survival but not neuronal differentiation of PC12 cells

1993 • 129 citations

bcl‐2, a novel reguator of cell death

1995 • 128 citations

bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells [published erratum appears in J Cell Biol 1995 Nov;131(4):following 1121]

1995 • 106 citations

Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells.

1995 • 99 citations

Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimerʼs disease

1996 • 92 citations

Function and expression of the Bcl-x gene in the developing and adult nervous system

1995 • 91 citations

The bcl-2 oncogene and apoptosis.

1992 • 90 citations

bcl-2 protein expression in aged brain and neurodegenerative diseases

1994 • 71 citations

Cellular death in neuroblastoma: in situ correlation of apoptosis and bcl‐2 expression

1995 • 66 citations

The molecular mechanisms of neuronal apoptosis

1994 • 64 citations

Expression of the protooncogene bcl-2 in Alzheimer's disease brain

1996 • 50 citations

Death Gives Birth to the Nervous System. But How?

1993 • 41 citations

Possible role of neuronal apoptosis in Alzheimer's disease

1994 • 35 citations

Progressive B-cell chronic lymphocytic leukaemia frequently exhibits aberrantp53 expression

1994 • 20 citations

Apoptosis and Cancer

1997 • 15 citations