Substrate‐Bound β‐Amyloid Peptides Inhibit Cell Adhesion and Neurite Outgrowth in Primary Neuronal Cultures

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

1994 • 1,463 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Mechanism of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction

1997 • 1,005 citations

Mechanisms of Neuronal Degeneration in Alzheimer's Disease

1996 • 956 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Cell-to-substratum adhesion and guidance of axonal elongation

1975 • 677 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Interactions of developing neurons with the extracellular matrix

1994 • 308 citations

Extracellular Matrix 2: Role of extracellular matrix molecules and their receptors in the nervous system

1993 • 276 citations

Temperature dependence of amyloid β-protein fibrillization

1998 • 260 citations

Plaque-induced neurite abnormalities: Implications for disruption of neural networks in Alzheimer’s disease

1999 • 228 citations

Regulation of Amyloid Precursor Protein Cleavage

1999 • 224 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Cholinergic regulation of neurite outgrowth from isolated chick sympathetic neurons in culture

1995 • 150 citations

Alzheimer's Disease and the Amyloid β Protein

1999 • 141 citations

β-Amyloid induces neuritic dystrophy in vitro

1992 • 132 citations

Alzheimer's Disease: A Description of the Structural Lesions

1991 • 113 citations

Increased Aβ42(43) from cell lines expressing presenilin 1 mutations

1998 • 100 citations

Survival of cultured neurons from amyloid precursor protein knock-out mice against Alzheimer's amyloid-beta toxicity and oxidative stress.

1998 • 90 citations

Localization of amyloid precursor protein in GAP43-immunoreactive aberrant sprouting neurites in Alzheimer's disease

1992 • 88 citations

Binding of secreted human neuroblastoma proteoglycans to the Alzheimer's amyloid A4 peptide

1993 • 84 citations

An interaction between basement membrane and Alzheimer amyloid precursor proteins suggests a role in the pathogenesis of Alzheimer's disease.

1995 • 74 citations

Role of Proteoglycans in Neural Development, Regeneration, and the Aging Brain

1996 • 69 citations

Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.

1993 • 68 citations

Cationic dyes reveal proteoglycans structurally integrated within the characteristic lesions of Alzheimer's disease

1989 • 67 citations

Expression of the amyloid protein precursor of Alzheimer's disease in the developing rat olfactory system

1995 • 50 citations

Extracellular matrix components and amyloid in neuritic plaques of Alzheimer's disease

1993 • 32 citations

Amnesia and Distributed Memory

1986 • 22 citations

Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections

1998 • 6 citations