Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Platelet-derived growth factor promotes smooth muscle migration and intimal thickening in a rat model of balloon angioplasty.

1992 • 681 citations

Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression.

1994 • 632 citations

Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty

1985 • 586 citations

Platelet-derived growth factor receptor signals.

1994 • 561 citations

Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity.

1992 • 548 citations

Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia.

1996 • 486 citations

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 • 453 citations

Regulation of chemotaxis by the platelet-derived growth factor receptor-β

1994 • 441 citations

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation.

1994 • 414 citations

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse

1997 • 346 citations

Platelet‐derived growth factor is a chemoattractant for vascular smooth muscle cells

1982 • 340 citations

Signal transduction within the nucleus by mitogen-activated protein kinase.

1992 • 323 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

Role of endogenous platelet-derived growth factor in arterial smooth muscle cell migration after balloon catheter injury.

1993 • 243 citations

Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption.

1994 • 235 citations

Mitogen-Activated Protein Kinase Activation Is Involved in Platelet-Derived Growth Factor-Directed Migration by Vascular Smooth Muscle Cells

1997 • 219 citations

Apolipoprotein E Inhibits Platelet Aggregation through the L-Arginine:Nitric Oxide Pathway

1997 • 201 citations

Triggering signaling cascades by receptor tyrosine kinases

1992 • 168 citations

Intimal hyperplasia as a cause of restenosis after percutaneous transluminal coronary angioplasty.

1985 • 168 citations

Protein Kinase C δ Inhibits the Proliferation of Vascular Smooth Muscle Cells by Suppressing G1 Cyclin Expression

1997 • 167 citations

Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization.

1997 • 164 citations

[13] Isolation and characterization of apolipoprotein E

1986 • 155 citations

Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors.

1995 • 145 citations

Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.

1992 • 145 citations

Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3.

1994 • 135 citations

Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall.

1995 • 135 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

Plasma lipoprotein metabolism in transgenic mice overexpressing apolipoprotein E. Accelerated clearance of lipoproteins containing apolipoprotein B.

1992 • 112 citations

Role of oxidized human plasma low density lipoproteins in atherosclerosis: effects on smooth muscle cell proliferation

1992 • 106 citations

Platelet-derived Growth Factor Stimulates Protein Kinase A through a Mitogen-activated Protein Kinase-dependent Pathway in Human Arterial Smooth Muscle Cells

1996 • 102 citations

Contrasting Effects of Plasminogen Activators, Urokinase Receptor, and LDL Receptor–Related Protein on Smooth Muscle Cell Migration and Invasion

1996 • 100 citations

Effects of Adenovirus-Mediated Human Apo A-I Gene Transfer on Neointima Formation After Endothelial Denudation in Apo E–Deficient Mice

1997 • 94 citations

Peripheral Vascular Stenosis in Apolipoprotein E-Deficient Mice

1997 • 86 citations

Production of cholesterol-enriched nascent high density lipoproteins by human monocyte-derived macrophages is a mechanism that contributes to macrophage cholesterol efflux.

1994 • 85 citations

Oxidized low‐density lipoprotein is chemotactic for arterial smooth muscle cells in culture

1990 • 80 citations

The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor

1994 • 76 citations

Modulation of Nitric Oxide Production in Human Macrophages by Apolipoprotein-E and Amyloid-Beta Peptide

1997 • 69 citations

Suppression of growth factor-induced CYL1 cyclin gene expression by antiproliferative agents.

1992 • 68 citations

Apoprotein E-rich high density lipoproteins inhibit ovarian androgen synthesis.

1988 • 68 citations

Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism

1997 • 66 citations

Phosphatidylinositol turnover in mitogen-activated lymphocytes. Suppression by low-density lipoproteins

1980 • 62 citations

MAP kinase does not inactivate, but rather prevents the cyclin degradation pathway from being turned on in Xenopus egg extracts

1996 • 61 citations

Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A/G1B boundary

1995 • 59 citations

Expression of apolipoprotein E by cultured vascular smooth muscle cells is controlled by growth state.

1988 • 58 citations

Expression of the human apolipoprotein E gene suppresses steroidogenesis in mouse Y1 adrenal cells.

1991 • 55 citations

Suppression of cAMP-mediated signal transduction in mouse adrenocortical cells which express apolipoprotein E.

1991 • 43 citations

Mitogen-stimulated calcium ion accumulation by lymphocytes. Influence of plasma lipoproteins.

1979 • 35 citations

Accelerated atheromatous lesions in mouse hearts transplanted to apolipoprotein-E-deficient recipients.

1996 • 32 citations

Apolipoprotein ε4 homozygosity — a determinant of restenosis after coronary angioplasty

1994 • 32 citations

Close encounters with apolipoprotein E receptors

1996 • 31 citations

Calcium Modulates the Cyclin D1 Expression in a Rat Parathyroid Cell Line

1994 • 28 citations