Presenilin-1 Forms Complexes with the Cadherin/Catenin Cell–Cell Adhesion System and Is Recruited to Intercellular and Synaptic Contacts

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Translating cell biology into therapeutic advances in Alzheimer's disease

1999 • 1,592 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Cell binding function of E-cadherin is regulated by the cytoplasmic domain.

1988 • 811 citations

Presenilin is required for activity and nuclear access of Notch in Drosophila

1999 • 801 citations

MOLECULAR AND FUNCTIONAL ANALYSIS OF CADHERIN-BASED ADHERENS JUNCTIONS

1997 • 800 citations

Alpha 1(E)-catenin is an actin-binding and -bundling protein mediating the attachment of F-actin to the membrane adhesion complex.

1995 • 739 citations

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin.

1995 • 651 citations

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.

1994 • 633 citations

Assembly of the cadherin-catenin complex in vitro with recombinant proteins

1994 • 557 citations

Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells

1996 • 549 citations

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants

1999 • 494 citations

Laying it on thick

1999 • 471 citations

Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.

1985 • 429 citations

Molecular organization of the uvomorulin-catenin complex.

1992 • 378 citations

Protein Topology of Presenilin 1

1996 • 374 citations

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

1998 • 373 citations

Participation of the endoplasmic reticulum chaperone calnexin (p88, IP90) in the biogenesis of the cystic fibrosis transmembrane conductance regulator.

1994 • 359 citations

Effects of PS1 Deficiency on Membrane Protein Trafficking in Neurons

1998 • 356 citations

Catenins and zonula occludens-1 form a complex during early stages in the assembly of tight junctions.

1996 • 335 citations

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

1994 • 326 citations

Structure and Function in Rhodopsin. 7. Point Mutations Associated with Autosomal Dominant Retinitis Pigmentosa

1994 • 309 citations

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1997 • 299 citations

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins

1997 • 291 citations

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

1997 • 289 citations

Identification of a putative cell adhesion domain of uvomorulin.

1985 • 246 citations

A-CAM: a 135-kD receptor of intercellular adherens junctions. I. Immunoelectron microscopic localization and biochemical studies.

1986 • 241 citations

Biosynthesis of the cell adhesion molecule uvomorulin (E-cadherin) in Madin-Darby canine kidney epithelial cells.

1991 • 226 citations

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of β-catenin,a component of the presenilin protein complex

1999 • 224 citations

Alzheimer Presenilins in the Nuclear Membrane, Interphase Kinetochores, and Centrosomes Suggest a Role in Chromosome Segregation

1997 • 219 citations

Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells.

1994 • 209 citations

Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.

1996 • 203 citations

Evidence for a physical interaction between presenilin and Notch

1999 • 168 citations

Evidence for a Six-transmembrane Domain Structure of Presenilin 1

1997 • 154 citations

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

1998 • 154 citations

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1997 • 96 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 91 citations

The Cadherin Superfamily at the Synapse: More Members, More Missions

1998 • 89 citations

The Alzheimer amyloid precursor is associated with the detergent- insoluble cytoskeleton

1991 • 76 citations

Interaction of calcium with plasma membrane of epithelial (MDCK) cells during junction formation

1992 • 76 citations

Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains

1996 • 69 citations

Polarized endocytosis by Madin-Darby canine kidney cells transfected with functional chicken liver glycoprotein receptor.

1989 • 67 citations

Cell surface expression of the Alzheimer disease-related presenilin proteins

1997 • 63 citations

Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.

1997 • 53 citations

Enrichment of Presenilin 1 Peptides in Neuronal Large Dense‐Core and Somatodendritic Clathrin‐Coated Vesicles

1998 • 43 citations

Presenilin expression in the ocular lens

1998 • 39 citations