Increased expression and subcellular translocation of the mitogen activated protein kinase kinase and mitogen-activated protein kinase in Alzheimer's disease

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Clinical diagnosis of Alzheimer's disease

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The Global Deterioration Scale for assessment of primary degenerative dementia

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A protein factor essential for microtubule assembly.

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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

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Diagnosis of Alzheimer's Disease

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The mitogen-activated protein kinase signal transduction pathway

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Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

cPLA2 is phosphorylated and activated by MAP kinase

1993 • 1,858 citations

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

1989 • 1,752 citations

Phosphorylation of c-jun mediated by MAP kinases

1991 • 1,495 citations

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1991 • 1,344 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase

1990 • 1,087 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

MAPKs: new JNK expands the group

1994 • 949 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

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Phosphorylation affects the ability of tau protein to promote microtubule assembly.

1984 • 852 citations

Tau protein function in living cells.

1986 • 727 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

Plaques, tangles and dementia

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Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases

1991 • 579 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase

1991 • 491 citations

Advances in second messenger and phosphoprotein research

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Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Stimulation of Protein Tyrosine Phosphorylation by NMDA Receptor Activation

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The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

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Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques

1986 • 419 citations

Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in alzheimer's disease

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Phosphorylation determines two distinct species of tau in the central nervous system

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Alzheimer's Neurofibrillary Changes

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Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

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Distribution of cerebral degeneration in Alzheimer's disease

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Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells.

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Evidence for dendritic competition in the developing retina

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MAP kinase by any other name smells just as sweet

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Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus

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Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease

1988 • 308 citations

Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia

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p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

Beta amyloid precursor protein mediates neuronal cell‐cell and cell‐surface adhesion

1991 • 244 citations

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

1992 • 236 citations

Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease

1993 • 234 citations

Xenopus MAP kinase activator is a serine/threonine/tyrosine kinase activated by threonine phosphorylation.

1992 • 232 citations

A phosphorylation site located in the NH2-terminal domain of c-Myc increases transactivation of gene expression.

1991 • 231 citations

Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells. Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor

1993 • 224 citations

Retraction and Expansion of the Dendritic Tree of Motor Neurones of Adult Rats induced in vivo

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Expression of tau protein in non-neuronal cells: microtubule binding and stabilization

1992 • 215 citations

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

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Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex

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Congenital and acquired cognitive disorders

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Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region

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Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

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β-Amyloid protein promotes neuritic branching in hippocampal cultures

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Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

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Dendritic sprouting in Alzheimer's presenile dementia

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Basic fibroblast growth factor in Alzheimer's disease

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Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation.

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Microtubular reorganization and dendritic growth response in alzheimer's disease

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Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

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Regulation of the cellular and subcellular concentrations and distribution of cyclic nucleotide-dependent protein kinases.

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Hypothalamic pathology in Alzheimer's disease

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Phosphorylation of Xenopus mitogen-activated protein (MAP) kinase kinase by MAP kinase kinase kinase and MAP kinase.

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Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts.

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Pathological proteins Tau 64 and 69 are specifically expressed in the somatodendritic domain of the degenerating cortical neurons during Alzheimer's disease

1990 • 122 citations

p42/mitogen-activated protein kinase as a converging target for different growth factor signaling pathways: use of pertussis toxin as a discrimination factor.

1991 • 121 citations

Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity.

1991 • 118 citations

Brain Protein Kinase PK40erk Converts TAU into a PHF-like Form as Found in Alzheimer′s Disease

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Dendritic changes in the basal nucleus of meynert and in the diagonal band nucleus in Alzheimer's disease—A quantitative Golgi investigation

1986 • 113 citations

Neurotrophic action of Alzheimer's disease brain extract is due to the loss of inhibitory factors for survival and neurite formation of cerebral cortical neurons

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Induction of basic Fibroblast Growth Factor in Alzheimerʼs disease pathology

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Amyloid beta protein precursor is a mitogen

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NGF and other growth factors induce an association between ERK1 and the NGF receptor, gp140prototrk

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Immunoreactive Epidermal Growth Factor Receptors in Neuritic Plaques from Patients with Alzheimer's Disease

1988 • 103 citations

Mitogen-Activated Protein (MAP) Kinase Phosphorylation of MAP Kinase Kinase: Determination of Phosphorylation Sites by Mass Spectrometry and Site-Directed Mutagenesis1

1994 • 100 citations

Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease

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Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation

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Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.

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Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

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Alzheimer's Disease and Related Conditions

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Immunological characterization of avian MAP kinases: evidence for nuclear localization.

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Verteilungsmuster der senilen Ver�nderungen im Gehirn

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Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations.

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Neuronal alterations in patients with dementia: a Golgi study on biopsy samples

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Abnormally phosphorylated tau protein in Alzheimer's disease: Heterogeneity of individual regional distribution and relationship to clinical severity

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BRAIN GLUTAMATE DECARBOXYLASE IN PARKINSON'S DISEASE WITH PARTICULAR REFERENCE TO A PREMORTEM SEVERITY INDEX

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Expression of protein phosphatases (PP-1, PP-2A, PP-2B and PTP-1B) and protein kinases (MAP kinase and P34cdc2) in the hippocampus of patients with Alzheimer disease and normal aged individuals

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Verteilungsmuster der senilen Vernderungen im Gehirn: Die Beteiligung des limbischen Systems bei hirnatrophischen Prozessen des Seniums und bei Morbus Alzheimer

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Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. III. The basal forebrain compared with other subcortical areas

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The MAP kinase cascade. Discovery of a new signal transduction pathway

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Cholinergic Neurons of the Nucleus basalis Express Elevated Levels of Nerve Growth Factor Receptor mRNA in Senile Dementia of the Alzheimer Type

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Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury—II. Reactive expression of the nerve growth factor gene in astrocytes

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Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors.

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Degeneration of rat cholinergic basal forebrain neurons and reactive changes in nerve growth factor expression after chronic neurotoxic injury—I. Degeneration and plastic response of basal forebrain neurons

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Identification of an Activator of the Microtubule‐Associated Protein 2 Kinases ERK1 and ERK2 in PC12 Cells Stimulated with Nerve Growth Factor or Bradykinin

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Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities.

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Congenital and acquired cognitive disorders

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Degeneration and regeneration of motoneuron dendrites after ventral root crush: Computer reconstruction of dendritic fields

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Axonal sprouting induced in the sciatic nerve by the amyloid precursor protein (APP) and other antiproteases

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Growth of abnormal neurites in atypical Alzheimer's disease

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The binding of basic fibroblast growth factor to Alzheimer's neurofibrillary tangles and senile plaques

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MAP kinase cascade in astrocytes

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Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. I. Dendritic organisation of the normal human basal forebrain

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MAP kinases: activation, subcellular localization and role in the control of cell proliferation.

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The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor‐stimulated rat phaeochromocytoma (PC12) cells

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Epidermal growth factor receptor expression in demented and aged human brain

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Perisomatic sprouts immunoreactive for nerve growth factor receptor and neurofibrillary degeneration affect different neuronal populations in the basal nucleus in patients with Alzheimer's disease

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Severity of Dementia in Alzheimer Disease and Neurofibrillary Tangles in Multiple Brain Regions

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Neurotrophic factor for central cholinergic neurones is present in both normal and Alzheimer brain tissue

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Dendritic competition in the developing retina: Ganglion cell density gradients and laterally displaced dendrites

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Regulation of extracellular signal-regulated protein kinase-1 (ERK-1; pp44/mitogen-activated protein kinase) by epidermal growth factor and nerve growth factor in PC12 cells: implication of ERK1 inhibitory activities

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Maintenance of Neuronal Plasticity in the Reticular Core and Changes in Trophic Activity in Alzheimer's Disease

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DENDRITIC CHANGES IN SENILE AND PRESENILE DEMENTIA

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Alzheimer Disease Brain Extract Stimulates Branching of Laminin-Mediated Neuronal Processes

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