Isoforms of nitric oxide synthase

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase

1991 • 2,371 citations

Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase.

1994 • 2,216 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Role of nitric oxide synthesis in macrophage antimicrobial activity

1991 • 1,547 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide.

1993 • 1,127 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

Nitric oxide synthase isozymes. Characterization, purification, molecular cloning, and functions.

1994 • 1,102 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Induction of calcium-dependent nitric oxide synthases by sex hormones.

1994 • 1,074 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Nitric Oxide: First in a New Class of Neurotransmitters

1992 • 1,001 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

Nitric oxide in skeletal muscle

1994 • 972 citations

Management of patients with intramural hematoma of the thoracic aorta.

1993 • 896 citations

Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene

1993 • 881 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

1994 • 840 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization

1993 • 825 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life.

1993 • 778 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

1993 • 671 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta.

1993 • 658 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction.

1992 • 622 citations

Nitric oxide synthase is a cytochrome P-450 type hemoprotein

1992 • 617 citations

Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.

1992 • 616 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.

1991 • 599 citations

Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells.

1994 • 595 citations

N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.

1991 • 572 citations

Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle

1993 • 552 citations

Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women.

1994 • 543 citations

Macrophage deactivating factor and transforming growth factors-beta 1 -beta 2 and -beta 3 inhibit induction of macrophage nitrogen oxide synthesis by IFN-gamma.

1990 • 507 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Role of interferon regulatory factor 1 in induction of nitric oxide synthase.

1994 • 477 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages

1990 • 455 citations

Purification of a Ca²⁺/calmodulin‐dependent nitric oxide synthase from porcine cerebellum

1990 • 433 citations

Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase

1991 • 422 citations

Insulin Secretion from Pancreatic B Cells Caused by L-Arginine-Derived Nitrogen Oxides

1992 • 415 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.

1991 • 386 citations

Interleukin-10 (IL-10) inhibits the induction of nitric oxide synthase by interferon-γ in murine macrophages

1992 • 384 citations

Cloned, expressed rat cerebellar nitric oxide synthase contains stoichiometric amounts of heme, which binds carbon monoxide.

1992 • 368 citations

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

1993 • 329 citations

Cloning of Inducible Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells

1993 • 319 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells

1993 • 293 citations

Phosphorylation by calcium calmodulin-dependent protein kinase II and protein kinase C modulates the activity of nitric oxide synthase

1991 • 275 citations

Mechanical deformation of vessel wall and shear stress determine the basal release of endothelium-derived relaxing factor in the intact rabbit coronary vascular bed.

1992 • 253 citations

Pyrrolidine Dithiocarbamate Inhibits Induction of Nitric Oxide Synthase Activity in Rat Alveolar Macrophages

1993 • 249 citations

Regulation and subcellular location of nitrogen oxide synthases in RAW264.7 macrophages.

1992 • 248 citations

Up-regulation of nitric oxide synthase (NOS) gene expression together with NOS activity in the rat hypothalamo-hypophysial system after chronic salt loading: evidence of a neuromodulatory role of nitric oxide in arginine vasopressin and oxytocin secretion.

1994 • 245 citations

Purification of nitric oxide synthase from rat macrophages

1991 • 244 citations

Mechanism of suppression of nitric oxide synthase expression by interleukin-4 in primary mouse macrophages

1994 • 237 citations

Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase Gene

1994 • 230 citations

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

1995 • 220 citations

Immunohistochemical localization of nitric oxide synthase in the human placenta

1993 • 205 citations

Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line

1993 • 204 citations

Inducible Nitric Oxide Synthase Is Increased in Murine Lung Epithelial Cells by Cytokine Stimulation

1994 • 204 citations

Evidence for a bidomain structure of constitutive cerebellar nitric oxide synthase.

1994 • 201 citations

Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after local cerebral ischemia in rat

1994 • 200 citations

Nitric oxide synthase immunoreactivity in rat spinal cord

1992 • 193 citations

Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies

1993 • 191 citations

Cyclic AMP-elevating agents induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells. Synergism with the induction elicited by inflammatory cytokines.

1993 • 188 citations

HORMONE RESPONSE DOMAINS IN GENE TRANSCRIPTION

1992 • 185 citations

Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.

1993 • 182 citations

Islet Cell DNA Is a Target of Inflammatory Attack by Nitric Oxide

1993 • 180 citations

Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

1992 • 174 citations

Long-lasting expression of JUN and KROX transcription factors and nitric oxide synthase in intrinsic neurons of the rat brain following axotomy

1993 • 171 citations

Nitric oxide accounts for dose-dependent estrogen-mediated coronary relaxation after acute estrogen withdrawal.

1994 • 169 citations

Protein tyrosine kinase inhibitors decrease induction of nitric oxide synthase activity in lipopolysaccharide-responsive and lipopolysaccharide-nonresponsive murine macrophages.

1993 • 166 citations

Tetrahydrobiopterin, a cofactor for rat cerebellar nitric oxide synthase, does not function as a reactant in the oxygenation of arginine.

1991 • 164 citations

Dual mechanism for the control of inducible-type NO synthase gene expression in macrophages during activation by interferon-gamma and bacterial lipopolysaccharide. Transcriptional and post-transcriptional regulation.

1994 • 163 citations

Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.

1993 • 162 citations

Transcription and translation of inducible nitric oxide synthase in the pancreas of prediabetic BB rats

1993 • 156 citations

Brain nitric oxide synthase is a haemoprotein

1992 • 151 citations

Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation.

1993 • 151 citations

Isolation and Chromosomal Localization of the Human Endothelial Nitric Oxide Synthase (NOS3) Gene

1994 • 133 citations

Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity

1994 • 132 citations

Diethyldithiocarbamate inhibits induction of macrophage NO synthase

1993 • 132 citations

Nitric oxide: A signal for ADP-ribosylation of proteins

1994 • 132 citations

Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats.

1993 • 131 citations

Norepinephrine Suppresses Inducible Nitric Oxide Synthase Activity in Rat Astroglial Cultures

1993 • 129 citations

Organization of the bovine gene encoding the endothelial nitric oxide synthase

1994 • 124 citations

Induction of nitric oxide synthase gene by interleukin in vascular smooth muscle cells.

1993 • 123 citations

Steroid hormones modulate the production of nitric oxide and cGMP in the rat uterus.

1994 • 120 citations

Promoter Analysis of Human Inducible Nitric Oxide Synthase Gene Associated with Cardiovascular Homeostasis

1994 • 118 citations

Regulation of Inducible Nitric Oxide Synthase mRNA Levels by LPS, INF-γ, TGF-β, and IL-10 in Murine Macrophage Cell Lines and Rat Peritoneal Macrophages

1994 • 115 citations

Hepatocytes and Macrophages Express an Identical Cytokine-Inducible Nitric Oxide Synthase Gene

1993 • 113 citations

Phorbol esters induce nitric oxide synthase and increase arginine influx in cultured peritoneal macrophages

1993 • 111 citations

Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart

1992 • 111 citations

Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin.

1990 • 111 citations

Identification of an endothelial-like type III NO synthase in LLC-PK1 kidney epithelial cells

1994 • 110 citations

Colocalization of nitric oxide synthase and NADPH-diaphorase in cultured myenteric neurons

1992 • 98 citations

Expression of nitric oxide synthase immunoreactivity by interstitial cells of the canine proximal colon

1994 • 97 citations

The induction of nitric oxide synthase activity is inhibited by TGF-β1, PDGFAB and PDGFBB in vascular smooth muscle cells

1992 • 96 citations

Immunochemical detection of inducible NO synthase in human lung

1994 • 94 citations

Endothelial nitric oxide synthase is myristylated

1992 • 93 citations

Nitric oxide synthase immunoreactivity in rat superior cervical ganglia and adrenal glands

1993 • 91 citations

Colocalization of nitric oxide synthase and somatostatin immunoreactivity in rat dentate hilar neurons.

1994 • 89 citations

Inducible nitric oxide synthase from human articular chondrocytes: cDNA cloning and analysis of mRNA expression

1994 • 89 citations

Developmental changes of cytosolic and particulate nitric oxide synthase in rat brain

1993 • 87 citations

Nifedipine inhibits the induction of nitric oxide synthase by bacterial lipopolysaccharide.

1993 • 80 citations

Immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with Propionibacterium acnes and lipopolysaccharide

1993 • 80 citations

Transforming Growth Factor β Differentially Modulates the Inducible Nitric Oxide Synthase Gene in Distinct Cell Types

1993 • 79 citations

Characterization and localization of nitric oxide synthase in non‐adrenergic non‐cholinergic nerves from bovine retractor penis muscles

1992 • 77 citations

Inducible nitric oxide synthase mRNA and activity in glomerular mesangial cells

1994 • 75 citations

Purification of Insoluble Nitric Oxide Synthase from Rat Cerebellum1

1992 • 73 citations

Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-ß

1992 • 72 citations

Interleukin‐1 ‐induced expression of nitric oxide synthase in insulin‐producing cells is preceded by c‐fos induction and depends on gene transcription and protein synthesis

1993 • 70 citations

Interleukin-8 inhibits the induction of nitric oxide synthase in rat peritoneal neutrophils

1992 • 68 citations

Molecular cloning of a cDNA encoding an inducible calmodulin‐dependent nitric‐oxide synthase from rat liver and its expression in COS 1 cells

1993 • 66 citations

Localization of the Human Gene for Inducible Nitric Oxide Synthase (NOS2) to Chromosome 17q11.2-q12

1994 • 64 citations

Nicotinamide and dexamethasone inhibit interleukin-1-induced nitric oxide production by RINm5F cells without decreasing messenger ribonucleic acid expression for nitric oxide synthase.

1993 • 64 citations

Different induction mechanisms of mRNA for inducible nitric oxide synthase in rat smooth muscle cells in culture and in aortic strips

1994 • 63 citations

Regional localization of the gene coding for human brain nitric oxide synthase (NOS1) to 12q24.2→24.31 by fluorescent in situ hybridization

1993 • 62 citations

Insulin-like growth factor I inhibits induction of nitric oxide synthase in vascular smooth muscle cells.

1994 • 60 citations

Nitric Oxide Synthase in Bovine Superior Cervical Ganglion

1993 • 60 citations

Mapping of the Genes Encoding Human Inducible and Endothelial Nitric Oxide Synthase (NOS2 and NOS3) to the Pericentric Region of Chromosome 17 and to Chromosome 7, Respectively

1994 • 58 citations

“Macrophage” nitric oxide synthase is a glucocorticoid‐inhibitable primary response gene in 3T3 cells

1993 • 51 citations

Cloning and Functional Expression of Human Inducible Nitric Oxide Synthase (NOS) cDNA from a Glioblastoma Cell Line A-1721

1994 • 50 citations

Monocyte Chemotactic Protein-1 Inhibits the Induction of Nitric Oxide Synthase in J774 Cells

1993 • 28 citations

Cloning and expression of a cDNA encoding human endothelium-derived relating factor/nitric oxide synthase.

1992 • 28 citations

Dissociation between Interleukin-1β-Induced Expression of mRNA for Superoxide-Dismutase and Nitric Oxide Synthase in Insulin-Producing Cells

1994 • 17 citations

Particulate Endothelial Nitric Oxide Synthase: Requirement and Content of Tetrahydrobiopterin, FAD, and FMN

1993 • 16 citations

The inducible nitric oxide synthase gene, Nos2, maps to mouse Chromosome 11

1994 • 12 citations