Membrane transporters in drug development

Goodman & Gilman's The Pharmacological Basis of Therapeutics

1985 • 7,054 citations

Goodman and Gilman's the Pharmacological Basis of Therapeutics

1986 • 6,964 citations

A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability.

1995 • 5,050 citations

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

2008 • 1,939 citations

Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding

2009 • 1,842 citations

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

2005 • 1,348 citations

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

2012 • 1,196 citations

Polyspecific Organic Cation Transporters: Structure, Function, Physiological Roles, and Biopharmaceutical Implications

2007 • 959 citations

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins

2004 • 940 citations

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

2007 • 913 citations

The superfamily of organic anion transporting polypeptides

2002 • 859 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Drug interactions with lipid-lowering drugs: Mechanisms and clinical relevance

2006 • 816 citations

Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System

2001 • 786 citations

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

2001 • 722 citations

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 • 675 citations

A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)

1999 • 630 citations

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

2000 • 611 citations

Polymorphisms in OATP-C

2001 • 605 citations

Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

2007 • 574 citations

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

2008 • 572 citations

Drug Interaction Studies: Study Design, Data Analysis, and Implications for Dosing and Labeling

2007 • 567 citations

Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1

1999 • 546 citations

The SLC22 drug transporter family

2004 • 519 citations

The Gut as a Barrier to Drug Absorption

2001 • 518 citations

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

2003 • 514 citations

Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex.

1993 • 508 citations

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

1998 • 497 citations

Transporters as a determinant of drug clearance and tissue distribution

2006 • 482 citations

Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics

2007 • 461 citations

Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment

2005 • 459 citations

Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918

2002 • 452 citations

SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

2006 • 444 citations

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the Hepatic Uptake of Pitavastatin in Humans

2004 • 438 citations

Involvement of Organic Cation Transporter 1 in Hepatic and Intestinal Distribution of Metformin

2002 • 434 citations

OCT-1–mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib

2006 • 433 citations

ABCG2: A perspective

2008 • 429 citations

In Vitro P-glycoprotein Assays to Predict the in Vivo Interactions of P-glycoprotein with Drugs in the Central Nervous System

2007 • 425 citations

The Utility of in Vitro Cytochrome P450 Inhibition Data in the Prediction of Drug-Drug Interactions

2005 • 422 citations

Increased drug delivery to the brain by P-glycoprotein inhibition

2000 • 422 citations

Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

2007 • 414 citations

Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family

2008 • 406 citations

SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid

2015 • 404 citations

The Role of Transporters in the Pharmacokinetics of Orally Administered Drugs

2009 • 404 citations

Structure, Function, Expression, Genomic Organization, and Single Nucleotide Polymorphisms of Human ABCB1 (MDR1), ABCC (MRP), and ABCG2 (BCRP) Efflux Transporters

2006 • 395 citations

ABCG2 Polymorphism Markedly Affects the Pharmacokinetics of Atorvastatin and Rosuvastatin

2009 • 388 citations

New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process

2008 • 373 citations

Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System Pharmacotherapy

2008 • 360 citations

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

2005 • 358 citations

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs

2006 • 347 citations

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

2008 • 345 citations

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

2003 • 344 citations

Involvement of Multiple Transporters in the Hepatobiliary Transport of Rosuvastatin

2008 • 335 citations

Most CML patients who have a suboptimal response to imatinib have low OCT-1 activity: higher doses of imatinib may overcome the negative impact of low OCT-1 activity

2007 • 335 citations

EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

2004 • 333 citations

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

2004 • 320 citations

Active secretion and enterocytic drug metabolism barriers to drug absorption

1996 • 310 citations

Clinical Pharmacokinetics of the Antiviral Nucleotide Analogues Cidofovir and Adefovir

1999 • 304 citations

DRUG-DRUG INTERACTION BETWEEN PITAVASTATIN AND VARIOUS DRUGS VIA OATP1B1

2006 • 294 citations

Evidence for inverse effects of OATP-C (SLC21A6) *5 and *1b haplotypes on pravastatin kinetics

2004 • 293 citations

Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil

2007 • 291 citations

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential—towards a consensus

2001 • 283 citations

Substrate-Dependent Drug-Drug Interactions between Gemfibrozil, Fluvastatin and Other Organic Anion-Transporting Peptide (OATP) Substrates on OATP1B1, OATP2B1, and OATP1B3

2007 • 282 citations

Reduction of metformin renal tubular secretion by cimetidine in man.

1987 • 281 citations

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine*

1995 • 275 citations

Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney

2004 • 275 citations

Organic Anion Transporters of the SLC22 Family: Biopharmaceutical, Physiological, and Pathological Roles

2007 • 271 citations

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

2008 • 270 citations

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

2005 • 268 citations

P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan

2007 • 264 citations

Drug–Drug Interactions Mediated Through P-Glycoprotein: Clinical Relevance and In Vitro–In Vivo Correlation Using Digoxin as a Probe Drug

2008 • 260 citations

Formation of extensive canalicular networks by rat hepatocytes cultured in collagen-sandwich configuration

1994 • 260 citations

Genetic Variants of the Organic Cation Transporter 2 Influence the Disposition of Metformin

2008 • 257 citations

Involvement of BCRP (ABCG2) in the Biliary Excretion of Pitavastatin

2005 • 253 citations

Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations

2003 • 252 citations

Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)

2005 • 250 citations

Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males

2006 • 247 citations

An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016): TABLE 1

2008 • 247 citations

Active secretion and enterocytic drug metabolism barriers to drug absorption1PII of original article: S0169-409X(96)003304. The article was originally published in Advanced Drug Delivery Reviews 20 (1996) 99–112.1

2001 • 238 citations

Pharmacogenetics of ABCG2 and Adverse Reactions to Gefitinib

2006 • 236 citations

Transcellular Transport of Organic Anions Across a Double-transfected Madin-Darby Canine Kidney II Cell Monolayer Expressing Both Human Organic Anion-transporting Polypeptide (OATP2/SLC21A6) and Multidrug Resistance-associated Protein 2 (MRP2/ABCC2)

2002 • 232 citations

Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin

2009 • 231 citations

The drug efflux–metabolism alliance: biochemical aspects

2001 • 230 citations

Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice

2008 • 228 citations

In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.

2001 • 226 citations

Decreased Renal Organic Anion Secretion and Plasma Accumulation of Endogenous Organic Anions in OAT1 Knock-out Mice

2005 • 223 citations

Reduced Hepatic Uptake and Intestinal Excretion of Organic Cations in Mice with a Targeted Disruption of the Organic Cation Transporter 1 (Oct1 [Slc22a1]) Gene

2001 • 223 citations

In vitro-in vivo Extrapolation of Transporter-mediated Clearance in the Liver and Kidney

2009 • 222 citations

The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin

2005 • 220 citations

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

1999 • 219 citations

Single nucleotide polymorphisms modify the transporter activity of ABCG2

2005 • 219 citations

P-Glycoprotein Recognition of Substrates and Circumvention through Rational Drug Design

2005 • 215 citations

ABCG2: structure, function and role in drug response

2007 • 213 citations

The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

2005 • 208 citations

Vectorial Transport by Double-Transfected Cells Expressing the Human Uptake Transporter SLC21A8 and the Apical Export Pump ABCC2

2001 • 204 citations

Multidrug resistance and the role of P-glycoprotein knockout mice

1995 • 199 citations

BREAST CANCER RESISTANCE PROTEIN (BCRP/ABCG2) TRANSPORTS FLUOROQUINOLONE ANTIBIOTICS AND AFFECTS THEIR ORAL AVAILABILITY, PHARMACOKINETICS, AND MILK SECRETION

2006 • 196 citations

Pharmacokinetic Interactions of Cimetidine 1987

1987 • 195 citations

Identification of the Hepatic Efflux Transporters of Organic Anions Using Double-Transfected Madin-Darby Canine Kidney II Cells Expressing Human Organic Anion-Transporting Polypeptide 1B1 (OATP1B1)/Multidrug Resistance-Associated Protein 2, OATP1B1/Multidrug Resistance 1, and OATP1B1/Breast Cancer Resistance Protein

2005 • 192 citations

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)

2004 • 189 citations

A regulatory viewpoint on transporter-based drug interactions

2008 • 186 citations

Structural Requirements for Drug Inhibition of the Liver Specific Human Organic Cation Transport Protein 1

2008 • 186 citations

Effect of Breast Cancer Resistance Protein (Bcrp/Abcg2) on the Disposition of Phytoestrogens

2007 • 182 citations

Drug interactions at the blood-brain barrier: Fact or fantasy?☆

2009 • 178 citations

Global Analysis of Genetic Variation in SLCO1B1

2007 • 176 citations

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

2009 • 174 citations

Effect of () variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers

2005 • 171 citations

Reduced-Function SLC22A1 Polymorphisms Encoding Organic Cation Transporter 1 and Glycemic Response to Metformin: A GoDARTS Study

2009 • 170 citations

PREDOMINANT CONTRIBUTION OF OATP1B3 TO THE HEPATIC UPTAKE OF TELMISARTAN, AN ANGIOTENSIN II RECEPTOR ANTAGONIST, IN HUMANS

2006 • 167 citations

Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers*1

2004 • 165 citations

Sex-Dependent Expression and Activity of the ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (BCRP/ABCG2) in Liver

2005 • 162 citations

Impact of Genetic Polymorphisms of Transporters on the Pharmacokinetic, Pharmacodynamic and Toxicological Properties of Anionic Drugs

2008 • 162 citations

Drug/Drug Interaction Between Lopinavir/Ritonavir and Rosuvastatin in Healthy Volunteers

2008 • 158 citations

Hepatic uptake of cholecystokinin octapeptide by organic anion-transporting polypeptides OATP4 and OATP8 of rat and human liver

2001 • 157 citations

Pharmacogenetic Characterization of Sulfasalazine Disposition Based on NAT2 and ABCG2 (BCRP) Gene Polymorphisms in Humans

2008 • 157 citations

Scientific Perspectives on Drug Transporters and Their Role in Drug Interactions

2006 • 155 citations

Species Difference in the Inhibitory Effect of Nonsteroidal Anti-Inflammatory Drugs on the Uptake of Methotrexate by Human Kidney Slices

2007 • 154 citations

Breast Cancer Resistance Protein (Bcrp/abcg2) Is a Major Determinant of Sulfasalazine Absorption and Elimination in the Mouse

2006 • 153 citations

Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies UsingMrp2(Abcc2) Knockout Mice

2006 • 152 citations

Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR

2008 • 151 citations

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

2004 • 150 citations

Clinical Pharmacokinetics of Ranolazine

2006 • 150 citations

Is This the Drug or Dose for You?: Impact and Consideration of Ethnic Factors in Global Drug Development, Regulatory Review, and Clinical Practice

2008 • 148 citations

Mechanism of multidrug recognition by MDR1/ABCB1

2007 • 146 citations

Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)

2006 • 141 citations

ABCB1 Pharmacogenetics: Progress, Pitfalls, and Promise

2007 • 141 citations

Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe

2008 • 137 citations

The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib

2008 • 137 citations

Role of organic cation transporters in the renal handling of therapeutic agents and xenobiotics

2005 • 131 citations

Physiology, structure, and regulation of the cloned organic anion transporters

2008 • 131 citations

Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.

2000 • 129 citations

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

2009 • 128 citations

Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite

2008 • 122 citations

Xenobiotic Transporters: Ascribing Function from Gene Knockout and Mutation Studies

2007 • 122 citations

Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics

2008 • 122 citations

Methotrexate Pharmacokinetics in Transgenic Mice with Liver-Specific Expression of Human Organic Anion-Transporting Polypeptide 1B1 (SLCO1B1)

2008 • 122 citations

A Global Drug Inhibition Pattern for the Human ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (ABCG2)

2007 • 121 citations

Organic cation transporters

2008 • 121 citations

In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

2007 • 116 citations

Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans

1982 • 115 citations

Predicting P-glycoprotein substrates by a quantitative structure–activity relationship model

2004 • 114 citations

Fosamprenavir

2006 • 113 citations

Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin

2008 • 111 citations

BCRP Transports Dipyridamole and is Inhibited by Calcium Channel Blockers

2005 • 110 citations

Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human

2008 • 109 citations

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

2008 • 108 citations

The Important Role of Bcrp (Abcg2) in the Biliary Excretion of Sulfate and Glucuronide Metabolites of Acetaminophen, 4-Methylumbelliferone, and Harmol in Mice

2006 • 108 citations

[45] Transport function and substrate specificity of multidrug resistance protein

1998 • 106 citations

Effects of Atazanavir/Ritonavir or Fosamprenavir/Ritonavir on the Pharmacokinetics of Rosuvastatin

2008 • 106 citations

Pharmacophore-based discovery of ligands for drug transporters

2006 • 105 citations

Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2

2004 • 98 citations

Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics

2006 • 96 citations

Multi-level Analysis of Organic Anion Transporters 1, 3, and 6 Reveals Major Differences in Structural Determinants of Antiviral Discrimination

2008 • 95 citations

Pharmacokinetics and pharmacodynamics of pravastatin in pediatric and adolescent cardiac transplant recipients on a regimen of triple immunosuppression

2004 • 94 citations

Use of Tc-99m Mebrofenin as a Clinical Probe to Assess Altered Hepatobiliary Transport: Integration of In Vitro, Pharmacokinetic Modeling, and Simulation Studies

2008 • 92 citations

A New Strategy of High-Speed Screening and Quantitative Structure-Activity Relationship Analysis to Evaluate Human ATP-Binding Cassette Transporter ABCG2-Drug Interactions

2006 • 91 citations

Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients

2006 • 90 citations

Investigation of the Inhibitory Effects of Various Drugs on the Hepatic Uptake of Fexofenadine in Humans

2008 • 88 citations

Structural Variation Governs Substrate Specificity for Organic Anion Transporter (OAT) Homologs

2007 • 87 citations

Use of Sandwich-Cultured Hepatocytes To Evaluate Impaired Bile Acid Transport as a Mechanism of Drug-Induced Hepatotoxicity

2007 • 87 citations

Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.

2006 • 86 citations

Effect of Human Renal Cationic Transporter Inhibition on the Pharmacokinetics of Varenicline, a New Therapy for Smoking Cessation: An In Vitro–In Vivo Study

2007 • 85 citations

Differential Involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in Biliary Excretion of 4-Methylumbelliferyl Glucuronide and Sulfate in the Rat

2006 • 84 citations

Kidney-specific expression of human organic cation transporter 2 (OCT2/SLC22A2) is regulated by DNA methylation

2008 • 84 citations

Drug and toxicant handling by the OAT organic anion transporters in the kidney and other tissues

2007 • 80 citations

Drugdrug interactions involving membrane transporters in the human kidney

2006 • 79 citations

Unexpected Mexiletine Responses of a Mutant Cardiac Na⁺ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

2004 • 74 citations

A LC–MS/MS method to quantify the novel cholesterol lowering drug ezetimibe in human serum, urine and feces in healthy subjects genotyped for SLCO1B1

2005 • 74 citations

Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors

2008 • 72 citations

Vectorial Transport of the Peptide CCK-8 by Double-Transfected MDCKII Cells Stably Expressing the Organic Anion Transporter OATP1B3 (OATP8) and the Export Pump ABCC2

2005 • 71 citations

QSAR analysis and molecular modeling of ABCG2-specific inhibitors

2008 • 69 citations

Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments

2009 • 69 citations

Pharmacogenomic importance of ABCG2

2008 • 69 citations

Effect of cimetidine and ranitidine on pharmacokinetics and pharmacodynamics of a single dose of dofetilide

2000 • 68 citations

Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells

2008 • 68 citations

PhRMA White Paper on ADME Pharmacogenomics

2008 • 66 citations

Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function

2008 • 66 citations

Multichannel Liquid Chromatography–Tandem Mass Spectrometry Cocktail Method for Comprehensive Substrate Characterization of Multidrug Resistance-Associated Protein 4 Transporter

2007 • 65 citations

Human ABC Transporter ABCG2 in Xenobiotic Protection and Redox Biology

2006 • 64 citations

Predictors of Vinorelbine Pharmacokinetics and Pharmacodynamics in Patients With Cancer

2006 • 64 citations

Amino Acid Residues in Transmembrane Domain 10 of Organic Anion Transporting Polypeptide 1B3 Are Critical for Cholecystokinin Octapeptide Transport

2008 • 64 citations

In Vitro and Pharmacophore-Based Discovery of Novel hPEPT1 Inhibitors

2005 • 63 citations

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

2009 • 61 citations

Ins and outs of the ABCG2 multidrug transporter: An update on in vitro functional assays

2008 • 60 citations

Stereoselective inhibition of pindolol renal clearance by cimetidine in humans

1992 • 58 citations

Biochemical and Molecular Pharmacological Aspects of Transporters as Determinants of Drug Disposition

2005 • 57 citations

Val133 and Cys137 in Transmembrane Segment 2 Are Close to Arg935 and Gly939 in Transmembrane Segment 11 of Human P-glycoprotein

2004 • 56 citations

Effect of cimetidine and probenecid on pilsicainide renal clearance in humans

2000 • 53 citations

Future directions for drug transporter modelling

2007 • 53 citations

Severe arrhythmia as a result of the interaction of cetirizine and pilsicainide in a patient with renal insufficiency: First case presentation showing competition for excretion via renal multidrug resistance protein 1 and organic cation transporter 2

2006 • 51 citations

In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein

2004 • 51 citations

Blood–brain barrier transport of pramipexole, a dopamine D2 agonist

2007 • 48 citations

Action of EGF and PGE₂on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells

2004 • 46 citations

Uptake and Efflux Transporters for Conjugates in Human Hepatocytes

2005 • 45 citations

High‐Speed Screening of Human ATP‐Binding Cassette Transporter Function and Genetic Polymorphisms: New Strategies in Pharmacogenomics

2005 • 45 citations

Knocking Down Breast Cancer Resistance Protein (Bcrp) by Adenoviral Vector-Mediated RNA Interference (RNAi) in Sandwich-Cultured Rat Hepatocytes: A Novel Tool To Assess the Contribution of Bcrp to Drug Biliary Excretion

2008 • 44 citations

A novel method for the determination of biliary clearance in humans

2004 • 43 citations

Pharmacogenetics of Membrane Transporters: A Review of Current Approaches

2014 • 41 citations

Optimising drug development: strategies to assess drug metabolism/transporter interaction potential — towards a consensus

2001 • 40 citations

Mini Review on Molecular Modeling of P-Glycoprotein (Pgp)

2007 • 38 citations

Noninvasive assessment of hepatobiliary and renal elimination of cysteinyl leukotrienes by positron emission tomography

1995 • 37 citations

siRNA—Getting the message out

2006 • 37 citations

Dual Hereditary Jaundice: Simultaneous Occurrence of Mutations Causing Gilbert’s and Dubin-Johnson Syndrome

2005 • 35 citations

Studies of Human MDR1-MDR2 Chimeras Demonstrate the Functional Exchangeability of a Major Transmembrane Segment of the Multidrug Transporter and Phosphatidylcholine Flippase

1999 • 33 citations

Analysis of Catalytic Carboxylate Mutants E552Q and E1197Q Suggests Asymmetric ATP Hydrolysis by the Two Nucleotide-Binding Domains of P-Glycoprotein

2003 • 33 citations

Relationship of Hepatic Functional Imaging to Irinotecan Pharmacokinetics and Genetic Parameters of Drug Elimination

2006 • 32 citations

Tariquidar, a Selective P-glycoprotein Inhibitor, Does Not Potentiate Loperamide’s Opioid Brain Effects in Humans despite Full Inhibition of Lymphocyte P-glycoprotein

2008 • 31 citations

Difference between pharmacokinetics of mycophenolic acid (MPA) in rats and that in humans is caused by different affinities of MRP2 to a glucuronized form.

2007 • 28 citations

Silencing the Breast Cancer Resistance Protein Expression and Function in Caco-2 Cells Using Lentiviral Vector-Based Short Hairpin RNA

2009 • 24 citations

Quinidine-digoxin interaction: are the pharmacokinetics of both drugs altered?

1985 • 23 citations

Data-Based Mathematical Modeling of Vectorial Transport across Double-Transfected Polarized Cells

2007 • 22 citations

Pharmacogenetics of Membrane Transporters

2008 • 22 citations

Caki-1 Cells Represent an in vitro Model System for Studying the Human Proximal Tubule Epithelium

2007 • 22 citations

Can celecoxib affect P-glycoprotein-mediated drug efflux? A microPET study

2008 • 19 citations

Low-affinity uptake of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide (4-Di-1-ASP) in BeWo cells

2006 • 18 citations

99mTc-HIDA Cholescintigraphy in Children with Dubin-Johnson Syndrome

1983 • 13 citations

Caki-1 Cells as a Model System for the Interaction of Renally Secreted Drugs with OCT3

2008 • 13 citations