In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Physiological parameters in laboratory animals and humans.

1993 • 2,747 citations

The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data

2005 • 758 citations

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1977 • 753 citations

Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging.

1989 • 626 citations

Functional imaging of multidrug-resistant P-glycoprotein with an organotechnetium complex.

1993 • 508 citations

Uptake and retention of hexakis (2-methoxyisobutyl isonitrile) technetium(I) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence.

1990 • 463 citations

Species similarities and differences in pharmacokinetics.

1995 • 364 citations

Drug-induced liver injury: Summary of a single topic clinical research conference

2006 • 274 citations

P-glycoprotein increases from proximal to distal regions of human small intestine.

2003 • 269 citations

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.

1999 • 223 citations

Biliary excretion in primary rat hepatocytes cultured in a collagen-sandwich configuration

1999 • 219 citations

Role of transporters in drug interactions

2011 • 216 citations

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1977 • 209 citations

Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions

2001 • 184 citations

Metabolism and Transport of Oxazaphosphorines and the Clinical Implications

2005 • 180 citations

Inter‐individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

2003 • 163 citations

Methods To Evaluate Biliary Excretion of Drugs in Humans: An Updated Review

2006 • 152 citations

P-glycoprotein Expression, Localization, and Function in Sandwich-Cultured Primary Rat and Human Hepatocytes: Relevance to the Hepatobiliary Disposition of a Model Opioid Peptide

2004 • 150 citations

Mitochondrial Expression of the Human Equilibrative Nucleoside Transporter 1 (hENT1) Results in Enhanced Mitochondrial Toxicity of Antiviral Drugs

2004 • 144 citations

Hepatotoxicity with Thiazolidinediones

2001 • 135 citations

In vitro cytochrome P450 inhibition data and the prediction of drug-drug interactions: Qualitative relationships, quantitative predictions, and the rank-order approach

2005 • 134 citations

Use of Ca2+ modulation to evaluate biliary excretion in sandwich-cultured rat hepatocytes.

1999 • 132 citations

Modulation of the multidrug resistance P-glycoprotein: detection with technetium-99m-sestamibi in vivo.

1997 • 121 citations

Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2

2004 • 98 citations

Expression of recombinant human multidrug resistance P-glycoprotein in insect cells confers decreased accumulation of technetium-99m-sestamibi.

1994 • 97 citations

Hepatic clearance of drugs. III. Additional experimental evidence supporting the “wellstirred” model, using metabolite (MEGX) generated from lidocaine under varying hepatic blood flow rates and linear conditions in the perfused rat liverin situ preparation

1977 • 75 citations

Unexpected Mexiletine Responses of a Mutant Cardiac Na⁺ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access

2004 • 74 citations

In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein

2004 • 51 citations

MULTIPLE TRANSPORT SYSTEMS MEDIATE THE HEPATIC UPTAKE AND BILIARY EXCRETION OF THE METABOLICALLY STABLE OPIOID PEPTIDE [d-PENICILLAMINE^2,5]ENKEPHALIN

2004 • 46 citations

A novel method for the determination of biliary clearance in humans

2004 • 43 citations

Determination of the biliary excretion of piperacillin in humans using a novel method

2006 • 26 citations

Biliary Leak Demonstrated on Delayed Scan From Tc-99m Sestamibi Myocardial Imaging

1998 • 4 citations

Assessment of myocardial perfusion and viability with technetium-99m methoxyisobutyl isonitrile.

1991 • 3 citations