Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics

Functional polymorphisms of the human multidrug-resistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

2000 • 2,358 citations

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

2001 • 2,120 citations

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

1995 • 1,424 citations

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 • 1,000 citations

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

2001 • 722 citations

Molecular Identification and Characterization of Novel Members of the Human Organic Anion Transporter (OATP) Family

2000 • 636 citations

A Novel Human Hepatic Organic Anion Transporting Polypeptide (OATP2)

1999 • 630 citations

Polymorphisms in OATP-C

2001 • 605 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

Identification of a Novel Gene Family Encoding Human Liver-specific Organic Anion Transporter LST-1

1999 • 546 citations

Localization and Genomic Organization of a New Hepatocellular Organic Anion Transporting Polypeptide

2000 • 516 citations

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics

2003 • 514 citations

Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6

2001 • 507 citations

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

2004 • 419 citations

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

2003 • 344 citations

Rosuvastatin pharmacokinetics in heart transplant recipients administered an antirejection regimen including cyclosporine

2004 • 320 citations

Genetic Polymorphisms of Human Organic Anion Transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): Allele Frequencies in the Japanese Population and Functional Analysis

2002 • 316 citations

Evidence for inverse effects of OATP-C (SLC21A6) *5 and *1b haplotypes on pravastatin kinetics

2004 • 293 citations

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

2004 • 288 citations

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8)

2004 • 189 citations

Polymorphisms in a human kidney xenobiotic transporter, OCT2, exhibit altered function

2002 • 188 citations

A Naturally Occurring Mutation in the SLC21A6Gene Causing Impaired Membrane Localization of the Hepatocyte Uptake Transporter

2002 • 140 citations

INVOLVEMENT OF ORGANIC ANION TRANSPORTING POLYPEPTIDES IN THE TRANSPORT OF TROGLITAZONE SULFATE: IMPLICATIONS FOR UNDERSTANDING TROGLITAZONE HEPATOTOXICITY

2004 • 120 citations

Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene.

1999 • 110 citations

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

2003 • 83 citations

Genomic organization of the UGT2b gene cluster on human chromosome 4q13

2000 • 48 citations

Pharmacogenetic meta-analysis suggests that atrasentan is an organic anion transport protein C substrate

2004 • 8 citations

High-throughput determination of atrasentan in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry

2005 • 6 citations

Effect of rifampin (RIF) on the pharmacokinetics (PK) of atrasentan (ABT-627, ATN)

2004 • 4 citations