The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin

A multidrug resistance transporter from human MCF-7 breast cancer cells

1998 • 2,273 citations

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

2002 • 807 citations

Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C.

2002 • 682 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

2005 • 412 citations

Expression, Up-Regulation, and Transport Activity of the Multidrug-Resistance Protein Abcg2 at the Mouse Blood-Brain Barrier

2004 • 315 citations

Human Breast Cancer Resistance Protein: Interactions with Steroid Drugs, Hormones, the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and Transport of Cimetidine

2004 • 278 citations

Functional Analysis of SNPs Variants of BCRP/ABCG2

2004 • 257 citations

Renal organic anion transport system: pharmacological, physiological, and biochemical aspects.

1982 • 246 citations

Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotype*1

2004 • 241 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2).

2002 • 196 citations

P-Glycoprotein Limits Oral Availability, Brain, and Fetal Penetration of Saquinavir Even with High Doses of Ritonavir

2001 • 171 citations

Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats

2001 • 130 citations

Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

2001 • 85 citations

Active Transport of Nitrofurantoin into Human Milk

2001 • 83 citations

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

2004 • 83 citations

Phenomenology and Scientific Progress

2002 • 47 citations

Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk.

2001 • 45 citations

Studies on the distribution and excretion of certain nitrofurans.

1960 • 42 citations

Active transport of nitrofurantoin across a mouse mammary epithelial monolayer.

1997 • 41 citations

Active transport of nitrofurantoin across the mammary epithelium in vivo.

1997 • 37 citations

Studies on the absorption, distribution and elimination of nitrofurantoin in the rat.

1961 • 35 citations

Improved LC method to determine ivermectin in plasma

2003 • 31 citations

Inhibition of Nitrofurantoin Reduction by Menthol Leads to Enhanced Antimicrobial Activity

2003 • 16 citations

BASOLATERAL ACTIVE UPTAKE OF NITROFURANTOIN IN THE CIT3 CELL CULTURE MODEL OF LACTATION: Fig. 1.

2003 • 11 citations

Age-dependence of renal tubular reabsorption of nitrofurantoin.

1978 • 6 citations