In vitro substrate identification studies for p-glycoprotein-mediated transport: species difference and predictability of in vivo results.

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

BIOCHEMICAL, CELLULAR, AND PHARMACOLOGICAL ASPECTS OF THE MULTIDRUG TRANSPORTER

1999 • 2,049 citations

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 • 1,268 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

1998 • 1,058 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

P-Glycoprotein, a gatekeeper in the blood–brain barrier

1999 • 918 citations

The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

1999 • 911 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

Inhibition of P-Glycoprotein–Mediated Drug Transport

1999 • 395 citations

Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).

1992 • 335 citations

In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872)

1997 • 312 citations

P-Glycoprotein Deficiency in a Subpopulation of CF-1 Mice Enhances Avermectin-Induced Neurotoxicity

1997 • 203 citations

The Contribution of P‐glycoprotein to Pharmacokinetic Drug‐Drug Interactions

1999 • 199 citations

Altered Pharmacokinetics of Vinblastine in Mdr1a P-glycoprotein-Deficient Mice

1996 • 175 citations

Steroid Transport, Accumulation, and Antagonism of P-Glycoprotein in Multidrug-Resistant Cells

1996 • 154 citations

Disposition of ivermectin and cyclosporin A in CF-1 mice deficient in mdr1a P-glycoprotein.

1999 • 124 citations

Identification of a P-Glycoprotein-Deficient Subpopulation in the CF-1 Mouse Strain Using a Restriction Fragment Length Polymorphism

1997 • 123 citations

Characterization of the binding of [3H]-(+/-)-L-364,718: a new potent, nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors.

1986 • 120 citations

Antiestrogens and steroid hormones: Substrates of the human P-glycoprotein

1994 • 115 citations

Human (MDR1) and Mouse (mdr1,mdr3) P-glycoproteins Can Be Distinguished by Their Respective Drug Resistance Profiles and Sensitivity to Modulators

1995 • 109 citations

Differential transport properties of two mdr gene products are distinguished by progesterone.

1990 • 103 citations

Characterization of the binding of [3H]L-365,260: a new potent and selective brain cholecystokinin (CCK-B) and gastrin receptor antagonist radioligand.

1989 • 87 citations

In Vitro Activities of the Potent, Broad-Spectrum Carbapenem MK-0826 (L-749,345) against Broad-Spectrum β-Lactamase-and Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae and Escherichia coli Clinical Isolates

1999 • 80 citations

Heterologous expression of various P-glycoproteins in polarized epithelial cells induces directional transport of small (type 1) and bulky (type 2) cationic drugs.

1998 • 39 citations

Transporters and drug disposition.

2000 • 24 citations