A novel method for the determination of biliary clearance in humans

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

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1997 • 92 citations

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1976 • 72 citations

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1968 • 61 citations

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1996 • 28 citations

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1990 • 28 citations

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1990 • 25 citations

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1993 • 23 citations

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1982 • 15 citations

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1987 • 14 citations

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2000 • 13 citations

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1989 • 10 citations