An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016): TABLE 1

Lapatinib plus Capecitabine for HER2-Positive Advanced Breast Cancer

2006 • 3,283 citations

Phase II Trial of Lapatinib for Brain Metastases in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

2008 • 465 citations

Breast Cancer Metastasis to the Central Nervous System

2005 • 423 citations

The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients

2005 • 348 citations

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

2005 • 318 citations

P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of Topotecan

2007 • 264 citations

The Role of Efflux and Uptake Transporters inN-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine (GW572016, Lapatinib) Disposition and Drug Interactions

2008 • 234 citations

Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa).

2002 • 168 citations

Lapatinib: A novel EGFR/HER2 tyrosine kinase inhibitor for cancer

2006 • 162 citations

Lapatinib: Current Status and Future Directions in Breast Cancer

2006 • 153 citations

Blood–brain barrier and chemotherapeutic treatment of brain tumors

2006 • 138 citations

Altered expression of hepatic cytochromes P-450 in mice deficient in one or more mdr1 genes.

2000 • 106 citations

Synthesis and positron emission tomography studies of carbon-11-labeled imatinib (Gleevec)

2007 • 65 citations

Gefitinib (‘Iressa’, ZD1839) is active against brain metastases in a 77 year old patient

2005 • 14 citations

Lapatinib

2005 • 8 citations

Deleted Work

1955 • 0 citations