Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

Predicting Drug Disposition via Application of BCS: Transport/Absorption/ Elimination Interplay and Development of a Biopharmaceutics Drug Disposition Classification System

2005 • 1,348 citations

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1994 • 865 citations

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

2006 • 840 citations

Distribution of organelles and membranes between hepatocytes and nonhepatocytes in the rat liver parenchyma. A stereological study.

1977 • 827 citations

Physiologically Based Pharmacokinetic Modeling 1: Predicting the Tissue Distribution of Moderate-to-Strong Bases

2005 • 707 citations

OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.

1999 • 585 citations

Prediction of Pharmacokinetics Prior to In Vivo Studies. 1. Mechanism‐Based Prediction of Volume of Distribution

2002 • 527 citations

Simulation and prediction of in vivo drug metabolism in human populations from in vitro data

2007 • 510 citations

Impact of Drug Transporter Studies on Drug Discovery and Development

2003 • 493 citations

Transporters as a determinant of drug clearance and tissue distribution

2006 • 482 citations

Quantitative Atlas of Membrane Transporter Proteins: Development and Application of a Highly Sensitive Simultaneous LC/MS/MS Method Combined with Novel In-silico Peptide Selection Criteria

2008 • 474 citations

Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?

2008 • 471 citations

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption

2007 • 409 citations

A Priori Prediction of Tissue:Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically‐Based Pharmacokinetic Models in Drug Discovery

2000 • 399 citations

A UNIFIED MODEL FOR PREDICTING HUMAN HEPATIC, METABOLIC CLEARANCE FROM IN VITRO INTRINSIC CLEARANCE DATA IN HEPATOCYTES AND MICROSOMES

2005 • 356 citations

Physiologically Based Pharmacokinetic Modeling to Predict Transporter-Mediated Clearance and Distribution of Pravastatin in Humans

2008 • 345 citations

EVALUATION OF DRUG-DRUG INTERACTION IN THE HEPATOBILIARY AND RENAL TRANSPORT OF DRUGS

2004 • 333 citations

A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

2006 • 330 citations

Prediction of Pharmacokinetics Prior to In Vivo Studies. II. Generic Physiologically Based Pharmacokinetic Models of Drug Disposition

2002 • 282 citations

EVALUATION OF FRESH AND CRYOPRESERVED HEPATOCYTES AS IN VITRO DRUG METABOLISM TOOLS FOR THE PREDICTION OF METABOLIC CLEARANCE

2004 • 264 citations

Prediction of Human Drug Clearance from in Vitro and Preclinical Data Using Physiologically Based and Empirical Approaches

2005 • 246 citations

Correlation of biliary excretion in sandwich-cultured rat hepatocytes and in vivo in rats.

1999 • 223 citations

Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes

2004 • 219 citations

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics.

1996 • 218 citations

Role of transporters in drug interactions

2011 • 216 citations

THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING^†

2001 • 188 citations

Utility of Hepatocytes in Predicting Drug Metabolism: Comparison of Hepatic Intrinsic Clearance in Rats and Humans in Vivo and in Vitro

2003 • 183 citations

Whole-body physiologically based pharmacokinetic models

2007 • 180 citations

Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo

2007 • 141 citations

Physiologically based pharmacokinetics in Drug Development and Regulatory Science: A workshop report (Georgetown University, Washington, DC, May 29–30, 2002)

2004 • 128 citations

Influence of Drug Transporter Polymorphisms on Pravastatin Pharmacokinetics in Humans

2006 • 126 citations

Scaling factors to relate drug metabolic clearance in hepatic microsomes, isolated hepatocytes, and the intact liver: studies with induced livers involving diazepam.

1997 • 121 citations

Hepatocyte suspensions and cultures as tools in experimental carcinogenesis

1979 • 121 citations

In Vitro–In Vivo Correlation of Hepatobiliary Drug Clearance in Humans

2007 • 116 citations

Challenges and opportunities with modelling and simulation in drug discovery and drug development

2007 • 111 citations

Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

2008 • 108 citations

Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes

2001 • 107 citations

An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

2005 • 106 citations

Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model

2008 • 97 citations

Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine

2008 • 92 citations

Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

2005 • 92 citations

Investigation of the Inhibitory Effects of Various Drugs on the Hepatic Uptake of Fexofenadine in Humans

2008 • 88 citations

Effect of Fruit Juices on the Oral Bioavailability of Fexofenadine in Rats

2004 • 88 citations

The role of hepatic transporters in drug elimination

2008 • 87 citations

Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes

2002 • 83 citations

Prediction of in vivo intestinal absorption enhancement on P-glycoprotein inhibition, from rat in situ permeability

2005 • 78 citations

In Vitro Biliary Clearance of Angiotensin II Receptor Blockers and 3-Hydroxy-3-methylglutaryl-Coenzyme A Reductase Inhibitors in Sandwich-Cultured Rat Hepatocytes: Comparison with in Vivo Biliary Clearance

2008 • 77 citations

In Vivo use of the P450 inactivator 1-aminobenzotriazole in the rat: Varied dosing route to elucidate gut and liver contributions to first-pass and systemic clearance

2006 • 75 citations

Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes

2008 • 67 citations

In vitro–in vivoextrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects

2007 • 63 citations

Steady-State Brain Concentrations of Antihistamines in Rats

2004 • 63 citations

Interspecies Pharmacokinetic Comparisons and Allometric Scaling of Napsagatran, a Low Molecular Weight Thrombin Inhibitor

1999 • 57 citations

A Multicompartment Geometric Model of the Liver in Relation to Regional Induction of Cytochrome P450s

1997 • 54 citations

Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes

2006 • 53 citations

Impact of serum on clearance predictions obtained from suspensions and primary cultures of rat hepatocytes

2004 • 53 citations

Potential error in the measurement of tissue to blood distribution coefficients in physiological pharmacokinetic modeling. Residual tissue blood. II. Distribution of phencyclidine in the rat.

1991 • 52 citations

Uptake of teicoplanin by isolated rat hepatocytes: comparison with in vivo hepatic distribution.

2001 • 45 citations

IN VITRO AND IN VIVO CORRELATION OF THE INHIBITORY EFFECT OF CYCLOSPORIN A ON THE TRANSPORTER-MEDIATED HEPATIC UPTAKE OF CERIVASTATIN IN RATS

2004 • 36 citations

Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans

2008 • 35 citations

MEMBRANE TRANSPORT AS A DETERMINANT OF THE HEPATIC ELIMINATION OF DRUGS AND METABOLITES

1996 • 29 citations

Pharmacokinetic and pharmacodynamic evaluation for tissue-selective inhibition of cholesterol synthesis by pravastatin.

1998 • 18 citations