The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins

Tumour stem cells and drug resistance

2005 • 3,535 citations

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

Mycotoxins

2003 • 2,834 citations

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

Mammalian ABC Transporters in Health and Disease

2002 • 1,531 citations

Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview

2012 • 1,196 citations

Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)

2003 • 1,027 citations

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

2002 • 807 citations

The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors

2002 • 754 citations

Persistent expression of the ATP-binding cassette transporter, Abcg2, identifies cardiac SP cells in the developing and adult heart

2003 • 667 citations

Role of Breast Cancer Resistance Protein in the Bioavailability and Fetal Penetration of Topotecan

2000 • 640 citations

Importance of P-glycoprotein at blood–tissue barriers

2004 • 559 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Increased Oral Bioavailability of Topotecan in Combination With the Breast Cancer Resistance Protein and P-Glycoprotein Inhibitor GF120918

2002 • 452 citations

C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance.

2002 • 432 citations

The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk

2005 • 412 citations

Identification of a missense mutation in the bovine ABCG2 gene with a major effect on the QTL on chromosome 6 affecting milk yield and composition in Holstein cattle

2005 • 359 citations

The Effect of Bcrp1 (Abcg2) on the In vivo Pharmacokinetics and Brain Penetration of Imatinib Mesylate (Gleevec): Implications for the Use of Breast Cancer Resistance Protein and P-Glycoprotein Inhibitors to Enable the Brain Penetration of Imatinib in Patients

2005 • 348 citations

Use of P-glycoprotein and BCRP inhibitors to improve oral bioavailability and CNS penetration of anticancer drugs

2005 • 318 citations

Human Breast Cancer Resistance Protein: Interactions with Steroid Drugs, Hormones, the Dietary Carcinogen 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and Transport of Cimetidine

2004 • 278 citations

Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine

2003 • 274 citations

Side population cells and Bcrp1 expression in lung

2003 • 270 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

Reducing Liver Cancer--Global Control of Aflatoxin

1999 • 227 citations

The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin

2005 • 220 citations

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

2002 • 218 citations

Hepatic Oval Cells Have the Side Population Phenotype Defined by Expression of ATP-Binding Cassette Transporter ABCG2/BCRP1

2003 • 193 citations

Breast Cancer Resistance Protein and P-Glycoprotein in 149 Adult Acute Myeloid Leukemias

2004 • 189 citations

Drug excretion into breast milk—Overview

2003 • 163 citations

Sex-Dependent Expression and Activity of the ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (BCRP/ABCG2) in Liver

2005 • 162 citations

Transporter Gene Expression in Lactating and Nonlactating Human Mammary Epithelial Cells Using Real-Time Reverse Transcription-Polymerase Chain Reaction

2002 • 161 citations

Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk

2005 • 154 citations

`Side Population' cells in adult mouse testis expressBcrp1gene and are enriched in spermatogonia and germinal stem cells

2003 • 145 citations

Breast Cancer Resistance Protein (BCRP/ABCG2) Induces Cellular Resistance to HIV-1 Nucleoside Reverse Transcriptase Inhibitors

2003 • 144 citations

Occurrence of aflatoxin M₁in randomly selected North African milk and cheese samples

2004 • 102 citations

Drug use during breast-feeding.

1991 • 90 citations

The initiation of breast and prostate cancer

2002 • 88 citations

Active Transport of Nitrofurantoin into Human Milk

2001 • 83 citations

Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice.

2004 • 83 citations

Neonatal Exposure to Drugs in Breast Milk

2004 • 53 citations

Occurrence of aflatoxin M₁in domestic milk in Japan during the winter season

2004 • 53 citations

Detection of Single Nucleotide Polymorphisms in the ABCG2 Gene in a Dutch Population

2005 • 52 citations

Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice

1999 • 50 citations

Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the Milk of Healthy Women

2001 • 45 citations

Active transport of nitrofurantoin across the mammary epithelium in vivo.

1997 • 37 citations

Acyclovir, Ganciclovir, and Zidovudine Transfer into Rat Milk

2002 • 34 citations

Functional and molecular characterisation of mammary side population cells (vol 5, pg R1, 2003)

2003 • 32 citations

Acyclovir concentrations in human breast milk after valaciclovir administration

2002 • 29 citations