Carcinogen and Anticancer Drug Transport by Mrp2 in Vivo: Studies UsingMrp2(Abcc2) Knockout Mice

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues

1969 • 6,007 citations

Mammalian ABC Transporters in Health and Disease

2002 • 1,531 citations

Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins

1997 • 934 citations

The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria

2002 • 807 citations

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

1998 • 621 citations

The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability

2003 • 578 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line.

1999 • 475 citations

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

1997 • 432 citations

Hereditary Chronic Conjugated Hyperbilirubinemia in Mutant Rats Caused by Defective Hepatic Anion Transport

1985 • 352 citations

Interactions of the Human Multidrug Resistance Proteins MRP1 and MRP2 with Organic Anions

2000 • 313 citations

Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4)

2003 • 301 citations

Up-regulation of basolateral multidrug resistance protein 3 (Mrp3) in cholestatic rat liver

2001 • 284 citations

Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations

2003 • 252 citations

Canalicular multispecific organic anion transporter/multidrug resistance protein 2 mediates low-affinity transport of reduced glutathione

1999 • 246 citations

The breast cancer resistance protein (Bcrp1/Abcg2) restricts exposure to the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 234 citations

Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles

2004 • 229 citations

Immuno-Localization of H+/Peptide Cotransporter in Rat Digestive Tract

1996 • 223 citations

Evidence for Two Interacting Ligand Binding Sites in Human Multidrug Resistance Protein 2 (ATP Binding Cassette C2)

2003 • 195 citations

TISSUE DISTRIBUTION AND HEPATIC AND RENAL ONTOGENY OF THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN (MRP) FAMILY IN MICE

2005 • 189 citations

Methotrexate is excreted into the bile by canalicular multispecific organic anion transporter in rats.

1997 • 171 citations

Analysis of the In Vivo Functions of Mrp3

2005 • 168 citations

Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.

1997 • 158 citations

Characterization of Mice Lacking the Multidrug Resistance Protein Mrp2 (Abcc2)

2006 • 141 citations

Reverse-phase h.p.l.c. separation, quantification and preparation of bilirubin and its conjugates from native bile. Quantitative analysis of the intact tetrapyrroles based on h.p.l.c. of their ethyl anthranilate azo derivatives

1985 • 138 citations

A mutation in the drug transporter gene ABCC2 associated with impaired methotrexate elimination

2005 • 138 citations

Increased Bioavailability of the Food-Derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in MRP2-Deficient Rats

2001 • 130 citations

Increased oral bioavailability of paclitaxel by GF120918 in mice through selective modulation of P-glycoprotein.

2000 • 118 citations

Intestinal Transport of Irinotecan in Caco-2 Cells and MDCK II Cells Overexpressing Efflux Transporters Pgp, cMOAT, and MRP1

2002 • 116 citations

Expression of multidrug resistance‐associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays

2002 • 115 citations

The role of mdr1a P-glycoprotein in the biliary and intestinal secretion of doxorubicin and vinblastine in mice.

2000 • 87 citations

Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

2001 • 85 citations

A new rat mutant with chronic conjugated hyperbilirubinemia and renal glomerular lesions.

1992 • 76 citations

Determination of doxorubicin and metabolites in murine specimens by high-performance liquid chromatography

1998 • 75 citations

ALTERED HEPATOBILIARY DISPOSITION OF 5 (AND 6)-CARBOXY-2′,7′-DICHLOROFLUORESCEIN INAbcg2(Bcrp1) ANDAbcc2(Mrp2) KNOCKOUT MICE

2006 • 53 citations

Up-regulation of Mrp4 expression in kidney of Mrp2-deficient TR− rats

2005 • 52 citations

Heterocyclic amines: evaluation of their role in diet associated human cancer

1996 • 46 citations

Dubin-Johnson and Rotor Syndromes: Molecular Basis and Pathogenesis

1993 • 45 citations

Sensitive Determination of the Carboxylate and Lactone Forms of the Novel Antitumor Drug Irinotecan and Its Active Metabolite in Plasma by HPLC

1998 • 15 citations

EFFECTS OF MORPHINE ON METHOTREXATE DISPOSITION IN MICE

2004 • 4 citations

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